Sentences with phrase «host cell invasion»

Host cell invasion by medically important fungi.

They also identified 26 molecules that specifically inhibit parasite release or host cell invasion of P. falciparum.

Their results demonstrate that specific rhoptry and dense granule effector proteins that T. gondii secretes before and after host cell invasion, respectively, control the development of an effective host antitumor response, and increase the survival of mice with ovarian tumors.

Not exact matches

The findings, published in Cell Host & Microbe, may represent a breakthrough strategy for treating West Nile Virus after virus invasion of the brain and the central nervous system, noted senior author Priti Kumar, M.D., associate professor of infectious disease at Yale School of Medicine.

One of these genes codes for a protein that the team dubbed claudin - like apicomplexan microneme protein (CLAMP), which has a strong effect on the parasite's invasion of host cells.

The new imaging technique will allow researchers to see the effects of novel drugs on this final stage in the parasite's invasion strategy, researchers report online on this week in Cell Host & Microbe.

A team led by Dr. Thorsten Eierhoff and Junior Professor Dr. Winfried Römer from the Institute of Biology II, members of the Cluster of Excellence BIOSS Centre for Biological Signalling Studies of the University of Freiburg, has identified a novel mechanism of bacterial invasion: Pseudomonas aeruginosa uses lipids in the cell membrane to make its way into host cells.

Bacterial pathogens are well known to cause tissue damage by colonization, induction of intense inflammation, invasion of host cells, and production of toxins [59].

Background: Many pathogens secrete effector molecules to subvert host immune responses, to acquire nutrients, and / or to prepare host cells for invasion.

While erythrocyte invasion is a rapid process, the brief extracellular exposure of merozoites outside of their intra-erythrocytic niche places them in direct contact with host antibodies, which contribute to naturally acquired immunity to malaria [8, 9]; therefore, merozoite cell surface and secreted proteins have long been considered attractive targets for rational vaccine development.

Conversely, down - regulation of PKAc1 or stabilisation of a dominant - negative PKAr isoform that does not bind cAMP triggers premature parasite egress from infected cells followed by serial invasion attempts leading to host cell lysis.