Sentences with phrase «host cell receptors»

Recent research has shown that these stand - ins react differently to antibodies against the virus and to host cell receptors.

Pfizer's Selzentry (generic name, maraviroc), which went on sale in the United States in September, binds with host cell receptors to prevent the virus from attaching to and entering healthy host cells.

The vaccine works by blocking the ability of the viruses to bind to host cell receptors.

In addition, the strain isolated from lions and hyenas during the 1993/1994 epidemic had rare mutations in two viral proteins: the CDV - H protein, which binds to the host cell receptor (called SLAM CD 150) and therefore plays an important role to facilitate viral entry into host cells, and the CDV - V protein, which enables the virus to manipulate the innate immune response of the host.

Not exact matches

Specifically, when capsaicin frequently binds to receptors within the human central nervous system's TRPV1 channel (the sensory receptor system for pain and heat detection), these receptors deplete and this depletion results in a whole host of benefits for the central nervous system at large, including terminating cancer cells, increasing the metabolic rate and digestive efficiency, increasing circulatory blood flow, and combatting inflammation, and making you feel better about the world.

In the dark, the receptors quietly sit there, with no discernible effect on their host cells.

«Plasmodium falciparum malaria parasites have evolved several key - like molecules to enter into human red blood cells through different door - like host receptors.

«In the future, it should be possible to block these areas in the toxin and receptor in order to prevent the toxin from entering the host cell,» Papatheodorou explained.

MERS CoV (CoV stands for coronavirus) has on its surface an array of spike - shaped proteins that bind to host cells — specifically to receptor proteins called DPP4 on the surface of cells that line human airways.

But what keeps these receptors from reacting to the host cells» own nucleic acids in the cytoplasm and causing unwanted inflammation?

HCV invades cells in the body by binding to specific receptors on the cell, enabling the virus to enter it.2 Once inside, HCV hijacks functions of the cell known as transcription, translation and replication, which enables HCV to make copies of its viral genome and proteins, allowing the virus to spread to other sites of the body.2 When HCV enters the host cell, it releases viral (+) RNA that is transcribed by viral RNA replicase into viral -LRB--) RNA, which can be used as a template for viral genome replication to produce more (+) RNA or for viral protein synthesis.

Influenza infection begins when hemagglutinin binds to receptors on the host cell.

Now, Skehel, along with colleagues at Harvard, Yale, and Emory University in Atlanta, Georgia, has used that sequence to build the virus's hemagglutinin (HA)-- a protein that latches onto receptors on the host cell surface — and determine its structure.

Hemaggluttinin's second job — after latching onto the host receptor — is to fuse viral and host cells» membranes once the virus enters the cell.

For example, most of the H7N9 isolates from the outbreak turned out to have acquired a notorious flu - virus mutation that substitutes the amino acid leucine for glutamine in the part of the virus that grabs receptors on host cells.

To address this question, Sasisekharan and his team analyzed the structure of the H5N1 and H7N9 viruses, focusing on hemagglutinin (HA)-- a type of viral protein that binds to cell receptors in the respiratory tract of hosts.

Testing many variants, the team eventually found an artificial receptor design that worked well in cell culture, enabling host T cells to efficiently destroy cells producing antibodies to desmoglein, including those derived from PV patients.

Microbes that cause diseases like HIV, malaria, and hepatitis C exploit and often activate the same checkpoint pathways — cell surface receptors such as CTLA4 and PD - 1 — to slow immune cells and prevent their elimination by the host.

Platelet activating factor receptor and innate immunity: uptake of Gram positive bacterial cell wall into host cells and cell - specific pathophysiology.

Gern explains that the genetics of the receptor — which serves like a lock - and - key mechanism that allows the virus to enter and infect a host cell — influences who is likely to be most affected by the virus.

Mycoplasma compete with host cells for nutrients and can alter expression of receptors, ion channels, and growth factors resulting in changes to the cell line's growth and behavior.

Areas of particular interest are host - pathogen interactions, pattern recognition receptors, cellular signaling and immunometabolism, and myeloid cell development.

A family of receptors that enable disease - causing toxins produced by the bacterium Clostridium difficile to enter host cells in mice is identified in a study published in Nature this week.

Together the two proteins form a complex that binds to one of two known cell surface receptors, mediating entry into the host cell [31].