Sentences with phrase «host cell targets»

Several host cell targets are needed for replication of influenza and many other viruses.

Not exact matches

To figure out the identities of the host - cell targets, Linhardt's team, led by graduate student So Young Kim at the Rensselaer Polytechnic Institute, mixed the envelope protein with sugars called glycosaminoglycans, which the dengue virus uses for this purpose.

Most cells from a foreign donor, such as in transplanted organs, are targeted by the immune system, but «this one has found a way to suppress the immune system of its hosts long enough to let it be passed along,» he says.

On the flipside, targeting this growth factor or BCL - 2 could reduce NK cell numbers and offer potential therapies for immune disorders such as some types of autoimmune diseases, sepsis or graft versus host disease, a side effect of bone marrow transplants.

By tracking and understanding which host cell pathways are manipulated by these T. gondii proteins, scientists can identify potential new targets to develop more effective therapies against highly aggressive solid tumors.

«To have a therapy at our disposal that safely targets just the T cells causing graft - versus - host disease would represent a major step forward in stem cell transplantation.

«These results represent a significant advance in our understanding of how commensal microbes can regulate host intestinal immune responses and suggest that the identification of downstream targets in macrophages and dendritic cells along the GM - CSF axis can help the rationale design of novel strategies for the treatment of IBD patients with defective GM - CSF function,» explained Dr. Merad.

LLO lacking the PEST - like sequence accumulated in the host - cell cytosol, suggesting that this sequence targets LLO for degradation.

Therefore, identification of molecules that affect both parasites during their release from infected host cells not only highlights robustness of the complementary screening approach we adopted, but also conserved drug targets for pan anti-parasitic drug development,» Dr Dhanasekaran Shanmugam from NCL added.

The results of this original study are highly relevant to other human diseases that dependent on genome instability, such as fungal infection or cancer, and open new venues for anti-leishmanial drug discovery using host - directed strategies that target the parasite's metabolic dependence on the host cell, thus preventing the adaptive evolution of drug resistant parasites.

Before injecting nematodes with magnetic nanoparticles, the scientists first coated the manganese — iron nanoparticles with polyethylene glycol, a molecule that targeted the particles to the mucus layer of the amphid region (an opening near the nematode's mouth that hosts the nerve cells involved in the heat avoidance reflex).

Two - pore channels control Ebola virus host cell entry and are drug targets for disease treatment

Thus, the two small phages characterized for their lysis strategy, Qβ and the small DNA phage φX174, effect host lysis by targeting different enzymes in the multistep, universally conserved pathway of cell wall biosynthesis.

Takahashi predicts that in the future, selecting from different stem cell therapies will «depend on the target disease and the situation of the host.»

Finding an immune cell that targets a whole host of tumors and a virus that doesn't release too early, however, has been a challenge.

«Brain cancer cells are very good at evading the host immune system, because they do not express specific targets that can be recognized by immune cells,» said Liau, professor and vice chair of neurosurgery.

«Importantly, fighting a pathogen by hitting an enzyme from the host cell is likely to slow the emergence of drug resistance, because the pathogen can not easily escape through the selection of target mutations,» Professor Doerig said.

By targeting mitochondria, the bacterium ensures that the host cell will be permissive to its replication.

An international study led by researchers at Monash University» Biomedicine Discovery Institute (BDI) has shone light on the way the Hepatitis C Virus (HCV) hijacks the communication systems in the host cells it infects, uncovering potential new therapeutic targets for the disease.

Due to an increasing body of evidence which suggests that the host immune response may be critical to the efficacy of oncolytic virotherapy, Shah and his colleagues also developed an immunocompetent melanoma mouse model and explored treating with both stem cell loaded oHSV and immune checkpoint blockers such as the ones that target the PD - 1 / PD - L1 pathway.

Because the toxin does not target the tumor cells themselves but rather the host - derived blood vessel cells, the strategy could be efficacious for a wide range of tumor types, the NIH team notes.

Hemagglutinin (HA) and neuraminidase (NA) are the two predominant viral glycoproteins found in the viral envelope, and are the primary targets of the host immune system and are key factors in the entry and exit of influenza particles from host cells.

A Legionella effector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria.

Retraction: The Epstein - Barr Virus - encoded miR - BART22 targets MAP3K5 to promote host cell proliferative and invasive abilities in nasopharyngeal carcinoma Ruichao Chen, Minfeng Zhang, Qiulian Li, Hanzhen Xiong, Shaoyan Liu, Weiyi Fang, Qianbing Zhang, Zhen Liu, Xuehu Xu, Qingping Jiang Journal of Cancer 2017; 8:3130 - 3130

The focus is on molecular microbiology and virology, and includes topics such as genomics, the gamut of plant and animal host - pathogen interactions, host immune responses, characterization and evolution of virulence determinants, cell cycle and differentiation, symbiosis in plant and animal associations, environmental microbiology, biodiversity and evolution, population dynamics, sex and mutagenesis, antibiotic resistance and production, drug and vaccine targets, as well as aspects of prion diseases and of fungal and protozoan biology.

By teasing apart the structure of an enzyme vital to the parasites that cause toxoplasmosis and malaria, Whitehead Institute scientists have identified a potentially «drugable» target that could prevent parasites from entering and exiting host cells.

Transplanted organs, tissues and cells are targets of the host immune response, that, in the absence of adequate immunesuppression, lead to graft loss.

The proteins displayed on the merozoite cell surface have long been considered attractive vaccine targets because of their direct exposure to host antibodies; however, progress in understanding the functional role of these targets has been hindered by technical challenges associated with expressing these proteins in a functionally active recombinant form.

In preclinical research, tumor cells lysed by coxsackievirus A21 (CVA21), a naturally occurring «common cold» ICAM - 1 — targeted RNA virus, induced a secondary systemic host - generated antitumor immune response.

Because viruses have evolved such effective methods for finding their target and utilizing the host cells» own molecular machinery, scientists are modifying viruses into long - lasting therapeutic vehicles that can deliver drugs to specific cells or tissues or selectively target and destroy tumors.

If these results are confirmed and one or more of these FLT3 - targeted drugs become approved by the FDA, testing for the FLT3 biomarker may eliminate the need for thousands of patients to undergo stem cell transplantation (each allogeneic transplant costs hundreds of thousands of dollars and place recipients at grave risk of infection and other complications such as Graft vs. Host disease).

While erythrocyte invasion is a rapid process, the brief extracellular exposure of merozoites outside of their intra-erythrocytic niche places them in direct contact with host antibodies, which contribute to naturally acquired immunity to malaria [8, 9]; therefore, merozoite cell surface and secreted proteins have long been considered attractive targets for rational vaccine development.

Two new NSG mouse models allow immunological dissection of graft - versus - host disease (GVHD) responses and in vivo testing of therapeutic agents targeting human CD4 T cells.

Ken SHORTMAN, WEHI, Melbourne, AUS «Enhancing protective antibody responses by targeting vaccine antigens to Clec9A on dendritic cells» Host:...

Through a new study that explores one aspect of how the virus hijacks host cell machinery to replicate itself, UNC Lineberger Comprehensive Cancer Center researchers have gained insight into the workings of a potential drug target for hepatitis C.

On 25 March the Government of Nepal's REDD + Cell hosted a workshop to initiate the targeted support activities implemented by the UN-REDD Programme and executed by Forest Action, and gather recommendations on the methodology.

With more CD4 + cells at the scene of the infection, there are more cells for HIV to target, increasing its chance of successfully infecting a new host.