Sentences with phrase «host cytosol»
Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.
http://www.gastroenterologyandhepatology.net/ Not exact matches
LLO lacking the PEST - like sequence accumulated in the host - cell cytosol, suggesting that this sequence targets LLO for degradation.
One essential virulence mechanism constitutes the specialized secretion systems that are designed to penetrate host - cell membranes and insert pathogen proteins directly into the host cell's cytosol.
These cells relied on a protein called cyclic GMP - AMP synthase (cGAS) to sense the viral DNA in the cytosol before the foreign DNA became integrated into the host genome.
Perforin - 2 protects host cells and mice by restricting the vacuole to cytosol transitioning of a bacterial pathogen.