Sentences with phrase «host disease after»

Donor - type CD4 (+) CD25 (+) regulatory T cells suppress lethal acute graft - versus - host disease after allogeneic bone marrow transplantation.

A Phase III Randomized Open - Label Multi-Center Study of Ruxolitinib vs. Best Available Therapy in Patients with Corticosteroid - Refractory Chronic Graft vs Host Disease after Allogenic Stem Cell Transplantation (REACH 3)

«As a transplant physician, it's beyond heartbreaking to witness a patient develop severe acute graft - versus - host disease after having their leukemia cured through bone marrow transplant,» said Kean.

«Uncovering a mechanism causing chronic graft - vs - host disease after bone marrow transplant.»

Not exact matches

Where is the clear line in a progression from (1) using animal insulin to treat diabetes, to (2) using gene remodeling techniques to grow insulin in a host bacterium that will reproduce rapidly and from which a plentiful supply of insulin can be harvested, to (3) genetic surgery to replace the defective gene in a person diagnosed as diabetic, to (4) genetic surgery immediately after fertilization in order to replace the defective gene and alter the germ cells which would otherwise have transmitted the disease to one's offspring?

Johns Hopkins Kimmel Cancer Center scientists first used cyclophosphamide to prevent severe graft - versus - host disease (GVHD) after bone marrow transplant involving haploidentical or «half - matched» transplants, a treatment first used in 2000 at the Cancer Center to treat leukemias and other blood cancers.

They do their dirty work by infiltrating bacteria, including disease - causing germs, and destroying them from within: After latching onto bacteria, the phages bore inside and hijack the bacteria's genetic machinery, turning them into phage factories that eventually make so many copies that the cells burst, killing off the host.

«Preventing graft - versus - host disease and relapse after transplant requires a difficult balance of eliminating the bad, overactive effector T cells, without suppressing the good, regulatory T cells,» said Kean, who is also an associate professor of pediatrics at the University of Washington School of Medicine and a member of the Fred Hutchinson Cancer Research Center.

But immunologist Nordin Zeidner, chief of the Centers for Disease Control and Prevention's Vector - Host Laboratory in Fort Collins, Colorado, had doubts, and after retesting the technique found a success rate of just 20 to 30 percent in mice.

«Immunotherapy drug nearly eliminates severe acute graft - versus - host disease: Drug used to treat rheumatoid arthritis improves survival after hematopoietic stem cell transplant.»

«Protection for the gut barrier: New approach may prevent graft - versus - host disease: Activating signal paths could protect patients from dangerous immune reactions after stem cell transplantations.»

The findings, published in Cell Host & Microbe, may represent a breakthrough strategy for treating West Nile Virus after virus invasion of the brain and the central nervous system, noted senior author Priti Kumar, M.D., associate professor of infectious disease at Yale School of Medicine.

Scientists in Germany have developed a new approach that may prevent leukemia and lymphoma patients from developing graft - versus - host disease (GvHD) after therapeutic bone marrow transplants.

- host disease prophylaxis after related - donor transplant appears to be safe and associated with lower than expected incidence of acute GVHD.

After an initial acute disease state, that is kept in check by host immune response, bacteria as Pseudomonas aeruginosa and Staphylococcus aureus can establish persistent infections and colonize the host by evading immune surveillance.

After 7 years in UCC, he moved back to Cardiff University in 2008 to a senior lectureship, where he investigates the role of the gut microbiome in maintaining host health and initiating diseases not only of the gut, but throughout the host system.

The therapeutic potential of bone marrow transplantation (BMT) relies on the graft - versus - leukemia (GVL) effect, which is closely associated with graft - versus - host disease (GVHD), the major cause of morbidity and mortality after BMT (1 — 4).

Graft - versus - host disease (GVHD) is the major complication after allogeneic bone marrow transplantation.

Study results report that after a median 3.4 - year follow - up, the 100 - day cumulative incidence rate of grade II to IV acute graft - versus - host disease was 36 % for the 15 - mg / kg group vs. 29 % for the 30 - mg / kg group; cumulative incidence rate of nonrelapse mortality was 9 % for patients assigned to the 15 - mg / kg dose vs. 19 % in the 30 - mg / kg group.

His research interest is graft - versus - host disease (GVHD), an immune complication after a donor stem cell transplant.

His research interest is graft - versus - host disease, an immune complication after a donor stem cell transplant.

The unique characteristics of heartworms in the feline host help explain the differences in disease progression that cats undergo after infection.