«HIV particles do not cause AIDS, our own immune cells do: The virus turns
host immune cells into suicide machines, using them to spread the virus and cause the progression from HIV to AIDS.»
The virus
turns host immune cells into suicide machines, using them to spread the virus and cause the progression from HIV to AIDS
Altering proteins in one part of the virus to achieve a certain benefit, such as more efficient gene transfer or reduced recognition
by host immune cells, could end up destroying the structural integrity of the entire shell.
HIV can either be spread through free - floating virus that directly infect
the host immune cells or an infected cell can pass the virus to an uninfected cell.
For years, pathologists have observed that most tumors are infiltrated by
host immune cells, presumably ones that are attempting to destroy them.
ART suppresses the replication of HIV in
the host immune cell population and stops the progression of HIV - related disease.
Until now, experts thought that latency came about because
a host immune cell that became infected with HIV would naturally lower its activity level, thereby impeding the virus from taking further hold.
By playing with the protein, they showed that the virus could be switched on or off separate from the rhythms of
its host immune cell, indicating that the two processes were independent of one another.
It inserted its genes into
host immune cells, which then produced new viruses.
The research team also created a synthetic version of the virus in a lab and found that toying with Tat completely outside of
a host immune cell could also switch it on and off, building on a study published last year which concluded that latency was «hard - wired» into the virus.