Sentences with phrase «host immune genes»

I have been involved in elucidating the genetic associations between host immune genes and disease condition.

In this light, the microbes are as much part of the holobiont immune system as the host immune genes themselves.

It allows the analysis of host immune gene expression in relation to vaccination, infection, disease or therapy in larger cohorts.

Not exact matches

Host genes of the major histocompatibility complex (the genes that determine how mammals respond to pathogens) play a significant role in how the immune system responds to all pathogens.

By contrast, the HMS team homed in on one microbe at a time and its effects on nearly all immune cells and intestinal genes, an approach that offers a more precise understanding of the interplay between individual gut microbes and their hosts.

They systematically deleted genes for secreted effector proteins — molecules that the parasite injects into a host cell to modulate the immune system during infection — and injected the altered parasites into mice with aggressive ovarian cancer.

Altering proteins in one part of the virus to achieve a certain benefit, such as more efficient gene transfer or reduced recognition by host immune cells, could end up destroying the structural integrity of the entire shell.

With gene - editing tools such as CRISPR, scientists can now eliminate immune - provoking sugars from the surface of pig cells, introduce human genes that regulate blood coagulation to prevent dangerous clots, and snip out viral sequences that some fear could infect a human host.

In the Lyme bacteria's genome, the VlsE gene is preceded by «cassettes» which are normally not expressed, or made into individual proteins, but can recombine with VlsE to alter the expressed protein and thus present a novel challenge to a host's immune defenses.

Molecules produced on demand by the host's genes have lots of different jobs that might help or hurt the bugs: immune responses, digestive enzymes, physiological «climate control» and metabolism, among others.

Because parasites evolve quicker than their vertebrate hosts, immune genes need to be highly diverse to keep up with parasites and prevent infections.

The biofilm communities harbored genes related to disinfectant tolerance, which constituted 2.3 percent of the total annotated proteins — and a lower abundance of virulence determinants related to colonization and evasion of the host immune system.

They also identify factors that may be involved in duck host immune response to avian virus infection, including the avian and mammalian - defensin gene families.

These cells were developed using gene editing to disable the gene that causes donor immune cells to attack their host.

The researchers found that the salamanders overexpress several genes that might suppress an immune response, suggesting that the host cell experience is neutral or beneficial.

For example, when the researchers decoded the complete sequence of one extrachromosomal circular phage from a disease - causing Staphylococcus, they identified a number of genes that may help this strain evade a host's immune system and that could readily spread to other Staphylococcus bacteria.

Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the regulation of gene expression and modulation of the host immune response during ¿ - herpesviral infection.

Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the regulation of gene expression and modulation of the host immune response during gammaherpesvirus infection.

The SPD genes, some of them known to mediate host - cell attachment, modification of host immunity and immune evasion, frequently presented copy number variations across strains or were found amplified in tandems forming gene arrays.

Contingency genes are thought to be critical to the bacterium's ability to evade the host's immune defenses because they have a high rate of mutation which helps the bacterium adapt to a wide range of host environments.

INTERPRETATION: We have developed a gene gun mediated Abeta42 gene vaccination method that is efficient to break host Abeta42 tolerance without using adjuvant and induces a Th2 immune response.

It inserted its genes into host immune cells, which then produced new viruses.

To evade the acquired immune response of the host while persisting in the blood, B. hermsii subsequently undergoes antigenic variation by expressing different alleles of the vsp / vlp gene family.

Presentations will focus on: the genes associated with determining risk of developing melanoma; alterations of genes both in the germline and specifically in the melanoma tumour that affect outcome; understanding how the melanoma tumour interacts with the host's immune system; and how to use these new findings to improve patient care.

They help to digest your food, train your immune system to distinguish between friend & foe, turn your genes on and off, synthesize important vitamins that your body can't make on its own, aid in detoxification, neutralize cancer - causing compounds, and a host of other things.