Sentences with phrase «host immune response»

I am passionate to do research in innate immunity of host immune response to pathogens and inflammation.

The focus of my research is on understanding how cancer impacts host immune responses in patients, with the goal of developing novel treatments to restore / enhance immune function in cancer patients.

This protection does not depend on an intact host immune response.

Murine experiments showed heightened host immune responses against transplanted experimental tumors after inoculation with bacillus Calmette - Guérin (BCG).

«Single sex heartworm infections, host immune responses affecting the presence of circulating microfilariae and the administration of heartworm preventives can be factors which produce occult infections in dogs.»

After receiving her doctorate, Crystal Loving moved to the National Institutes of Health in Bethesda, Maryland, from a small research facility in Ames, Iowa, to study host immune responses to inhalational anthrax as an intramural postdoc.

After a flood of optimism and investment in the early 1990's, the struggle to overcome host immune response and fears that organs could transmit pig viruses to humans scared off pharmaceutical funders.

They also identify factors that may be involved in duck host immune response to avian virus infection, including the avian and mammalian - defensin gene families.

After an initial acute disease state, that is kept in check by host immune response, bacteria as Pseudomonas aeruginosa and Staphylococcus aureus can establish persistent infections and colonize the host by evading immune surveillance.

Conceptually, the antigen - specific enhancement of Treg cell function is of particular importance because such strategies will minimize the requirements for pharmaceutical immunosuppression, sparing desired protective host immune responses to infectious and malignant insults.

This surface coat is a monolayer of millions of variant surface glycoproteins (VSG) that protect the parasite from the innate immune system and, through antigenic variation, against the specific host immune response.

Complementing the investigations above, we are carrying out a longitudinal study on the gut microbiota of a cohort of approximately 100 individuals 3 - 11 years of age from Kalifabougou, Mali, to test the hypothesis that the composition of the human gut microbiome is associated with the quality of P. falciparum - induced host immune responses, the risk and severity of malarial episodes, and / or drugs used to treat the disease.

B. burgdorferi are obligate bacteria, meaning that they must reside within either an Ixodes spp. tick or another host in order to survive.3 In order to adapt to physiologic differences between hosts and to avoid host immune responses, they frequently change the proteins expressed on their outer surface.

Environmental factors and host immune response play an equally important role in causing CIRDC to develop.

«We know that regional shifts in the Arctic's climate might — directly or indirectly — change host - pathogen relationships as well as impact the efficiency of host immune responses,» says Karina Acevedo - Whitehouse, who works at the Autonomous University of Queretaro, Mexico, and the Institute of Zoology in London.

The focus of the work in the lab is based on a combination of approaches including investigating the role of glycan - lectin interactions and altered cell - surface glycosylation in mediating cellular processes central to immune regulation and human diseases; designing multi-omics approaches to study host immune response to HIV infection; and developing and implementing robust and sensitive molecular biology - based assays to measure cellular and tissue HIV reservoirs.

Mosquito saliva is known to modulate transmission of some insect - borne pathogens and influence the host immune responses, but its role in dengue disease is not well understood.

«It suggests there's a common mechanism in both species for susceptibility to tumor progression that may involve subversion of the host immune response.

«Once a pathogen establishes itself within a biofilm, it can be difficult to eradicate as biofilms provide a physical barrier against the host immune response, can be impermeable to antibiotics and act as a reservoir for persistent infection,» Scott said.

Researchers at the Stowers Institute have established a definitive link between the makeup of the microbiome, the host immune response, and an organism's ability to heal itself.

I study how these microorganisms interact through secreted products, such as proteins and small molecules, and how these interactions influence both biofilm formation and the host immune response.

Due to an increasing body of evidence which suggests that the host immune response may be critical to the efficacy of oncolytic virotherapy, Shah and his colleagues also developed an immunocompetent melanoma mouse model and explored treating with both stem cell loaded oHSV and immune checkpoint blockers such as the ones that target the PD - 1 / PD - L1 pathway.

Finally, third, changes in host pathology that can relate either to adverse effects generated by the invading microbe or indeed the host immune response itself [5].

Such antibodies are protective, at least in part, because they activate the host immune response which then destroys the whole HA / antibody complex.

The compound seems to act superior to Oseltamivir (Tamiflu) and independent of the host immune response.

Second, microbial virulence, the mechanism whereby the invading microbe seeks to evade or overcome the host immune response.

Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the regulation of gene expression and modulation of the host immune response during ¿ - herpesviral infection.

These tools are presently being applied to a number of questions relating to interactions occurring between pathogens and the host immune response.

Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the regulation of gene expression and modulation of the host immune response during gammaherpesvirus infection.

«We're able to define the symptoms and signs during the acute interval, and now we're working intensively on evaluating the relationship between the virus and the host immune response.»

«It's logical to do some things like chemotherapy to attack the tumor and some things like immunotherapy to make the host immune response work better,» says Steinman.

This finding may have implications for the host immune response or barrier function during infection.

(i) We identified the anti-adhesive and anti-inflammatory functions of the Staphylococcus aureus - derived factor, Extracellular Adherence Protein (Eap) and contributed to the understanding how bacteria subvert the host immune response.

Dr. Greenberg's laboratory is pursuing studies to elucidate the immunobiology of host immune responses to infectious viruses and transformed cells.

During this infection process, the bacterium produces many virulence factors, including a lethal toxin, that allow it to subvert the host immune response.

Host immune response is characterized by the activation and clonal expansion of allo - reactive T cells and, in the case of transplant in subjects with autoimmunity, also of memory auto - reactive clones.

For RV - C, the differences compared with RV - A and RV - B in these attributes suggest that the host immune responses against this virus may also differ from the other species.

Transplanted organs, tissues and cells are targets of the host immune response, that, in the absence of adequate immunesuppression, lead to graft loss.

«The protective role of curcumin to fight drug - resistant tuberculosis still needs confirmation, but if validated, curcumin may become a novel treatment to modulate the host immune response to overcome drug - resistant tuberculosis.»

Even the AHS admits on its website that «host immune responses affect the presence of circulating microfilariae»... in other words, your dog's immune system can kill the microfilariae or prevent them from reproducing.