These data suggest that human iPS - RPE cells are able to contribute to
host photoreceptor cell integrity by removing retinal debris at this time - point.
Not exact matches
But illumination of the network with a brief flash (10 milliseconds) of blue light causes each of these bacterial
photoreceptors to jolt their
host cell a bit.
A concomitant preservation of
host cone
photoreceptors was also observed.
Both unmodified and genetically modified groups were found to have cells that migrated and survived in two distinct locations: (i) as a separate, nearly continuous, subretinal layer lying between the
host RPE and
photoreceptors, and (ii) as individual cells distributed throughout the neurosensory retina, especially within the inner retinal layers (Figure 5A).
Qualitative examination of the
host anatomical response to the presence of hNPCctx or hNPCctx - GDNF revealed substantial preservation of the
photoreceptor outer nuclear layer (ONL) overlying all subretinal donor cells (Figure 5E and F), with
photoreceptor rescue gradually declining outside the distribution of the transplanted cells (Figure 5E and G).
To examine
host cone
photoreceptors, we performed antibody staining for cone arrestin antigen.
iPS - RPE cells were injected into the subretinal space between the
host RPE and
photoreceptor cells (B) A layer of iPS - RPE cells in the subretinal space of the dystrophic RCS rat 20 hours following transplantation.
Conservation of visual acuity in the iPS - RPE transplanted eyes was associated with the preservation of
photoreceptors in the
host outer nuclear layer (ONL — Fig. 7A), identified by the expression of rhodopsin in the outer segments of
photoreceptors (Fig. 7A inset, Dystrophic + transplant).