Both Wolbachia wAu, naturally associated with Drosophila simulans, and wMel, native to Drosophila melanogaster, have been previously described to protect
their hosts against viral infections.
This resulted in a staggering 50,000 virus -
host protein interactions, approximately 500 of which appeared to be involved in
viral infection.By removing the interacting
host proteins from the cell one at a time, the researchers were able to determine what their functional contribution was in the
infection process: whether the
host proteins were hijacked by the virus and used to spread
infection, or whether they were part of a defense mechanism
against the virus.