While the role that DNA - binding proteins play in regulating gene expression at the transcriptional level is well studied,
how RNA - binding proteins control gene expression at the post-transcriptional level is less clear.
In a nutshell, we use biochemical and biophysical approaches to explore
how RNA enzymes catalyze biological reactions.
Gary Bassell, a cell biologist at Emory, and his colleagues have been exploring
how RNA regulation works in neurons.
For nearly a decade, Sattler made contributions to RNA research, working to tease out
how RNA binding proteins uniquely bind to specific RNA and regulate gene expression.
Investigates
how RNA splicing contributes to breast and ovarian cancer progression, metastasis and drug - resistance.
They will also discuss
how RNA ISH complements IHC and will present data obtained with automation system from Leica and Ventana.
A viral potluck For almost 40 years, scientists have worked to understand
how RNA viruses can have so many mutations and still be so successful.
Jennifer Doudna and Samuel Sternberg used a combination of single - molecule imaging and bulk biochemical experiments to show
how the RNA - guided Cas9 enzyme is able to locate specific 20 - base - pair target sequences within genomes that are millions to billions of base pairs long.
Although this line of research is far from contributing to changes in the clinic, the team now has a much better understanding of
how RNA splicing is controlled in the ear.
CiviŠ's team is now trying to address
how the RNA bases came together with other complex molecules to form RNA.
Jamieson's team wanted to understand
how RNA might change with the aging of normal blood stem cells compared with sAML stem cells.
Yet scientists know relatively little about
how RNA decay is controlled, largely because methods of measuring degradation have been expensive and not applicable to human tissues.
Small's team has now worked out
how their RNA - binding proteins, called PPR, latch on to RNA.
The year's most stunning revelations emerged in the fall, in four papers examining
how RNA interference helps pilot a peculiar — and pervasive — genetic phenomenon known as epigenetics.
The game, called EteRNA, allows players to remotely carry out real experiments to verify their predictions of
how RNA molecules fold.
Changing
how the RNA folds can serve as a control knob in cellular processes — increasing, decreasing or altering activity in specific pathways — but determining how to make RNA so it folds in a particular way has long been a tedious and arduous process.
He wonders exactly
how the RNA viruses are infecting cells without harming them, allowing them to become a part of an animal's DNA.
«A wealth of papers have been written on
how this RNA is localized and regulated, but it was never clear what the Vg1 protein actually does in the developing embryo.»
Knowing the structure means scientists can explore
how RNA synthesis is working in these viruses.
Scientists already know
how these RNA viruses infect cells.
Now researchers have found
how RNA editing helps turn overheated male embryos into females (SN Online: 6/14/17).
And by 1993 he says, «It may turn out that we will eventually be able to see
how this RNA world got started.
[37] In another publication, Fletcher wrote that «I am afraid that reality has overtaken Meyer's book and its flawed reasoning» in pointing out scientific problems with Meyer's work by citing
how RNA «survived and evolved into our own human protein - making factory, and continues to make our fingers and toes.»
Oh ok cool, so you can tell
me how RNA mutated to DNA?
In another publication, Fletcher wrote that «I am afraid that reality has overtaken Meyer's book and its flawed reasoning» in pointing out scientific problems with Meyer's work by citing
how RNA «survived and evolved into our own human protein - making factory, and continues to make our fingers and toes.»
The two closely related regulatory genes are active in the normal development of mammals and govern
how RNAs produced from the genes are joined to make final versions of the encoded protein, a process called alternative splicing.
We also exploit the self - cleaving activity of small catalytic RNAs to learn
how RNAs fold into the precise three - dimensional structures that are needed to perform biological functions in vivo.
Not exact matches
Here's
how it works: When a bacterium encounters DNA from a virus, it makes a strand of
RNA, a molecular cousin to DNA, that matches the sequence of the viral DNA, known as a guide
RNA.
The DNA /
RNA can't just randomly appear, it is information, regardless of
how simple or complex you may think it is, it is information, information can not just appear.
If the odds are this great for a protein,
how high does this «raise the bar» when DNA and
RNA are factored in (and remember that there is more to the cell than just these three), for a cell to arise at random?
All of this believed to be truth in the Universe is, on the inside of man's brain and body and
how he creates his own DNA /
RNA of life in and around himself.
Also, about your «digital encoding» theory,
How else do you imagine a certain genetic trait is carried over generations unless it is somehow ingrained into the basic building genes and
RNAs?
At the same time, I know» and this was evident again at the
RNA convention»
how many reporters are devoutly religious (notably evangelical Protestant and Catholic), view their work as a vocation, genuinely want to be fair, and worry about purchasing journalistic plaudits at the price of truth.
You said science does not have any idea of
how DNA came to be... DNA was NOT the first genetic material on the planet DNA mostly likely came from
RNA (auto replicating) this transition from DNA to
RNA makes LUCA or the domains bacteria, protists and Archean (depending on which evolutionary theory you are following).
There is a lot to learn about
RNA, and research like this is
how we learn it.
«We still want to determine
how the lnc -
RNA does its job and when it does it job, and that will give us a better handle on
how to target it more effectively.»
I have been in many conversations where I confessed I didn't know
how to fix contaminations in my
RNA yields or other related technical problems.
RNA molecules can attach to particular DNA sequences to help control
how much protein these particular genes produce within a given time, and within a given cell.
Molecular biology chiefly concerns itself with understanding the interactions between the various systems of a cell, including the interrelationship of DNA,
RNA and protein synthesis and learning
how these interactions are regulated.
This must be
how the first genes, made of
RNA, would have copied themselves.
Ribosomes, the cellular factories that manufacture proteins, contain both
RNA and protein, but exactly
how all of the different ribosomal components contribute to protein synthesis is still not clear.
In his second semester, he started doing research in three different labs, including that of Carolyn Decker, a molecular biologist who was investigating
how the cell controls gene expression through the destruction of messenger
RNA.
Scientists from the Universities of Bath, Oxford and Edinburgh have now identified one such non-coding
RNA, called Paupar, which influences
how healthy brains develop during early life.
So, we were starting to look at
how simple molecules like sugars get across these fatty acid membranes, you know, spontaneously without any help from fancy proteins — and it turned out completely unexpectedly that ribose, which is one of the building blocks of
RNA, gets across a wide range of membranes much more quickly than a set of very closely related sugars.
Therefore, it is essential that we learn
how specific types of chemical modifications normally regulate
RNA function in our cells, in order to understand
how dysregulation of this process contributes to human disease, says Cristian Bellodi.
The evolution of the SARS virus — like flu, an
RNA virus — is a vivid example of
how a pathogen incubated in the markets of Guangdong managed to jump species and adapt to humans.
That is a good start, but it leaves unanswered the question:
How do you get from tiny snippets of
RNA to longer, well - crafted chains that could have acted as the first enzymes, doing fancy things like copying themselves The shortest
RNA enzyme chains known today are about 50 bases long; most have more than 100.
Zika, dengue and chikungunya (which are also found in Colombia) are
RNA viruses, which refers to
how they encode their genetic material, and each is transmitted by a specific mosquito called Aedes aegypti.
To understand
how Glo might bind to diverse
RNAs and regulate them in different ways, Gavis and graduate student Joel Tamayo collaborated with Traci Tanaka Hall and Takamasa Teramoto from the National Institute of Environmental Health Sciences to generate X-ray crystallographic structures of Glo's three
RNA - binding domains.
Noller (p. 1508) discusses
how the basic building block of
RNA — the double helix — has been fashioned into the intricate «protein - like» three - dimensional surfaces of the ribosome.