Sentences with phrase «how altered expression»

Our goal is to gain mechanistic understanding how altered expression or function of key mitotic regulators (e.g. GTPases, kinases) can give rise to genetically unbalanced cells that may initiate tumorigenesis.

Not exact matches

In what follows we will examine how Whitehead's theory of symbolic reference alters our understanding of the arts, and we will supplement his account with ideas derived from Merleau - Ponty's theory of expression.

Others have tracked the first few hours of the embryonic development of sea urchins and other organisms with the goal of seeing how various transcription factors alter gene expression over time.

It also remains unclear how knocking down expression of certain genes in zygotes via sperm miRNA leads to altered stress response in adult animals and altered gene expression in the brain.

For the first time, scientists have improved how a crop uses water by 25 percent without compromising yield by altering the expression of one gene that is found in all plants, as reported in Nature Communications.

«This is the first example of how early environment can alter gene expression without mutating the gene itself,» Jirtle says.

The team analysed the sperm of the offspring from the undernourished mothers to see how many genes had had their expression altered by the addition or removal of a methyl group — an epigenetic change.

These datasets will allow the characterization of how genetically different parasites that cause distinct types of human toxoplasmosis alter the expression of protein - encoding and miRNA - encoding genes in both the human host and the parasite.

I am currently exploring functions of BIN1 by generating mouse models to modify the levels of BIN1 expression in the brain, and investigating how altering the levels of this protein can modify AD - related pathophysiology.

A famous example of how transcription factor expression can be used to alter a cell's identity is the creation of iPSCs, where adult cells were forced to express transcription factors normally expressed in ESCs, which made the adult cells express genes specific to ESCs, and consequently become nearly identical to ESCs.

The researchers also showed just how flexible their LITE system could be by applying it to altering gene expression via epigenetics with the addition of histone modifiers.

I would like to research how chromatin modulation alters gene expression during early stages of differentiation using computational biology and experimental approaches.

Her current research is focused on discovering how normal and disease melanocyte cell states establish distinct regulatory DNA landscapes, and also determining how the combination of both genetic variation within these regulatory regions and environmental cell signals alter gene expression and normal cell function.

We are also examining how gene expression and mitochondrial function is altered in human cells in the disorder known as Chronic Fatigue Syndrome or Myalgic Encephalomyelitis, in order to develop objective tests for the illness as well to identify causal factors.

High - throughput ChIP - Seq: One of the major questions for researchers interested in understanding chromatin dynamics is to investigate how protein - DNA interactions alter Epigenetic profiles and subsequent gene expression.

These findings provide new insights into how chromatin regulation modulates stochastic gene expression and transcriptional bursting, with implications for regulation of pluripotency and development.Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription.

Furthermore, stated Dr. Malaspina, «our hypothesis and model right now for how paternal age affects the risk for schizophrenia is that it has altered the expression of genes inherited from the father.

In the book Relaxation Revolution: The Science and Genetics of Mind Body Healing, author Herbert (Benson) discusses how breathing can literally change the expression of genes, and that by using your breath, you can alter the basic activity of your cells with your brain.

Here's what you get during those minutes, according to new reports: an instant endorphin surge and drop in blood pressure, regulation of hunger hormones that may help you keep weight off, and key vitamin D synthesis that alters the expression of 291 genes responsible for everything from controlling how quickly your bones age to how fast you bounce back from tough workouts to how fertile you are.

Harvard University (2014) Centre of the Developing Child, How Early Experiences Alter Gene Expression and Shape Development Retrieved 28/9/2014 from