Our goal is to gain mechanistic understanding
how altered expression or function of key mitotic regulators (e.g. GTPases, kinases) can give rise to genetically unbalanced cells that may initiate tumorigenesis.
Not exact matches
In what follows we will examine
how Whitehead's theory of symbolic reference
alters our understanding of the arts, and we will supplement his account with ideas derived from Merleau - Ponty's theory of
expression.
Others have tracked the first few hours of the embryonic development of sea urchins and other organisms with the goal of seeing
how various transcription factors
alter gene
expression over time.
It also remains unclear
how knocking down
expression of certain genes in zygotes via sperm miRNA leads to
altered stress response in adult animals and
altered gene
expression in the brain.
For the first time, scientists have improved
how a crop uses water by 25 percent without compromising yield by
altering the
expression of one gene that is found in all plants, as reported in Nature Communications.
«This is the first example of
how early environment can
alter gene
expression without mutating the gene itself,» Jirtle says.
The team analysed the sperm of the offspring from the undernourished mothers to see
how many genes had had their
expression altered by the addition or removal of a methyl group — an epigenetic change.
These datasets will allow the characterization of
how genetically different parasites that cause distinct types of human toxoplasmosis
alter the
expression of protein - encoding and miRNA - encoding genes in both the human host and the parasite.
I am currently exploring functions of BIN1 by generating mouse models to modify the levels of BIN1
expression in the brain, and investigating
how altering the levels of this protein can modify AD - related pathophysiology.
A famous example of
how transcription factor
expression can be used to
alter a cell's identity is the creation of iPSCs, where adult cells were forced to express transcription factors normally expressed in ESCs, which made the adult cells express genes specific to ESCs, and consequently become nearly identical to ESCs.
The researchers also showed just
how flexible their LITE system could be by applying it to
altering gene
expression via epigenetics with the addition of histone modifiers.
I would like to research
how chromatin modulation
alters gene
expression during early stages of differentiation using computational biology and experimental approaches.
Her current research is focused on discovering
how normal and disease melanocyte cell states establish distinct regulatory DNA landscapes, and also determining
how the combination of both genetic variation within these regulatory regions and environmental cell signals
alter gene
expression and normal cell function.
We are also examining
how gene
expression and mitochondrial function is
altered in human cells in the disorder known as Chronic Fatigue Syndrome or Myalgic Encephalomyelitis, in order to develop objective tests for the illness as well to identify causal factors.
High - throughput ChIP - Seq: One of the major questions for researchers interested in understanding chromatin dynamics is to investigate
how protein - DNA interactions
alter Epigenetic profiles and subsequent gene
expression.
These findings provide new insights into
how chromatin regulation modulates stochastic gene
expression and transcriptional bursting, with implications for regulation of pluripotency and development.Polycomb repressive complexes modify histones but it is unclear
how changes in chromatin states
alter kinetics of transcription.
Furthermore, stated Dr. Malaspina, «our hypothesis and model right now for
how paternal age affects the risk for schizophrenia is that it has
altered the
expression of genes inherited from the father.
In the book Relaxation Revolution: The Science and Genetics of Mind Body Healing, author Herbert (Benson) discusses
how breathing can literally change the
expression of genes, and that by using your breath, you can
alter the basic activity of your cells with your brain.
Here's what you get during those minutes, according to new reports: an instant endorphin surge and drop in blood pressure, regulation of hunger hormones that may help you keep weight off, and key vitamin D synthesis that
alters the
expression of 291 genes responsible for everything from controlling
how quickly your bones age to
how fast you bounce back from tough workouts to
how fertile you are.
Harvard University (2014) Centre of the Developing Child,
How Early Experiences
Alter Gene
Expression and Shape Development Retrieved 28/9/2014 from