The team wanted to know
how the bacterial populations in the gut change when exposed to the medicinal herbs.
With this new understanding of
how bacterial populations evolve survival strategies against antibiotics, scientists could develop new approaches for slowing the evolution of antibiotic resistance.
«We sort of had a nightmare scenario and an intentionally high concentration in order to better understand
how the bacterial population would respond,» Smith says.
Not exact matches
If a
bacterial population can become antibiotic - resistant even when only a small number of individuals have the appropriate genetic mutations, doctors who collect and analyze small
bacterial specimens from patients may underestimate just
how resistant the infection is as a whole, Collins notes.
Flavell warned that more research is necessary to learn
how many
bacterial species fall into the «bad» category and whether those
populations are common to all IBD patients or are unique to each patient.
Based on these observations, the researchers developed a mathematical model to identify
how this biased partitioning of the drug pump affects the
bacterial population.
This provides new opportunities related to the study of
how the heterogeneities that appear at lower levels of the functional hierarchy, for example at the level of
bacterial populations, eventually end up in the same chemical pattern that is specific to different diseases.
Sequencing can quantify
how populations of specific
bacterial strains vary under given experimental conditions, allowing the investigators to look for connections with disorders in the mice.
We then examined
how parasitic infection reduced the hindgut
bacterial population.
Read the details: Silver effective against pathogenic organisms, and explore
how silver can, via direct contact, reduce
bacterial population counts from over ten million copies to undetectable in under four minutes.
They are currently undertaking a study that aims to explore differences in intestinal
bacterial populations among epileptic dogs and healthy housemates, and evaluate
how antiepileptic drugs affect the growth rates of intestinal bacteria.