Sentences with phrase «how cell shape»

Anja (McGill University, Quebec, Canada) is world - renowned for her work in the cell biology of the pollen tube, work that addresses biomechanical aspects, such as how cell shape is determined, and how materials are secreted appropriately to direct cell growth.

The tool will enable better phenotyping of cell shapes and also understanding of how cell shapes change in relation to others, and over time.

Not exact matches

Donald Ingber, M.D., Ph.D., Founding Director of the Wyss Institute at Harvard University, started investigating this «architecture of life» over thirty - five years ago, and discovered that Nature uses an architectural principle known as «tensegrity» (short for «tensional integrity») to stabilize the shapes of living cells and to determine how they respond to mechanical forces.

Lagasse, based at Pitt's McGowan Institute for Regenerative Medicine, has discovered how to turn any one of the body's 500 lymph nodes — the small, oval - shaped organs where immune cells gather to fight invading pathogens — into an incubator that can grow an entirely new liver.

Once researchers understand the rules for how to get specific shapes with TZPs that also assemble into larger structures, they can design materials with desired functions — for example, a membrane for a battery, a catalyst for a fuel cell, or even a therapeutic drug.

Shape plays an important role in how bacteria infiltrate and attack cells in the body.

Hochstein is lead author of a study that explains how a lemon - shaped virus assembles itself and how the virus ejects the DNA it carries into host cells.

Her most recent paper — this one published in PNAS, the official journal of theNational Academy of Sciences — explains a totally new way that viruses operate in building particles and how viruses can change shapes to interact with their host cells.

Researchers know that shape is determined by the cell wall, yet little is known about how bacteria monitor and control it.

The scientists» findings have wide implications in the effort to understand how organs are sculpted into their shapes and how cells respond to their native mechanical environment both in healthy tissues and during disease.

«We showed that the coupling of cell wall growth to mechanical strain is quantitatively consistent with how bacteria recovered their shape after being deformed in experiments.»

He and colleagues have determined what gives cholera bacteria their curved shape and whether it matters (a polymer protein, and it does matter; the curve makes it easier for cholera to cause disease), how different wavelengths of light affect movement of photosynthetic bacteria (red and green wavelengths encourage movement; blue light stops the microbes in their tracks), how bacteria coordinate cell division machinery and how photosynthetic bacteria's growth changes in light and dark.

But little is known about how ionizing radiation affects the extracellular matrix (ECM), a patchwork of proteins and other biomolecules that surrounds cells and plays a vital role in their shape, movement and signaling functions.

By studying how mitochondria respond to a parasitic infection, Pernas has begun to probe the ways access to nutrients in the cell — which both the cell and the parasite need — shapes an infection.

Now, findings from Monell reveal that a person's sensitivity to bitter taste is shaped not only by which taste genes that person has, but also by how much messenger RNA — the gene's instruction guide that tells a taste cell to build a specific receptor — their cells make.

While researchers at the Georgia Institute of Technology don't have a specific application for the doughnut - shaped droplets yet, they believe the novel structures offer opportunities to study many interesting problems, from looking at the properties of ordered materials within these confined spaces to studying how geometry affects how cells behave.

In a paper published Sept. 21 in Cell, Harvard Medical School genetics professor Olivier Pourquié — whose lab discovered the segmentation clock 20 years ago — and colleagues report that they used mouse cells to reconstitute a stable version of this clockwork for the first time in a petri dish, leading to several new discoveries about where the clock is located, what makes it tick and how the vertebral column takes shape.

Darwin wrote about how evolution shapes the destiny of whole organisms, but its principles apply to individual cells, too.

Apart from advancing our understanding of how plants regulate their growth and shape, this research presents new questions for stem cell researchers in regards to cell size checkpoints and their importance during organism development.

The researchers explored how to tune the size, shape and morphology of materials known as cell - penetrating self - assembling peptide nanomaterials, or CSPNs.

Illinois researchers found that the shape of a tumor may play a role in how cancer cells become primed to spread.

With a cell - by - cell assessment of gene activity they are monitoring how precursor cells shape and organize themselves into something loosely resembling a functioning liver.

Eggan has been working with Steve McCarroll, associate professor of genetics at Harvard Medical School and director of genetics at the Stanley Center, to study how genes shape the biology of neurons, which can be derived from these stem cells.

The new model, which is a scaled - down version of an earlier numerical model by Shaqfeh and colleagues that provided the first large - scale, quantitative explanation of the formation of the layer, can predict how blood cells with varying shapes, sizes, and properties — including the crescent - shaped cells that are the hallmark of sickle cell anemia — will influence blood flow.

Obtaining detailed insights into their three - dimensional shape will not only help to understand how they function but also how this function is regulated in the cell.

They reveal for the first time how this candelabra - shaped cell interacts with hundreds of excitatory cells in its neighborhood, receiving information from some, imparting information to others.

King said that by studying how the shape of proteins change, researchers can determine how drugs bind and interact with cells.

Her hope is that this fundamental understanding of Stentor's regeneration process will help clarify the connections between regeneration and cell division, leading to new, broader insights about how cells produce and maintain their shape.

«I'm interested in understanding how single cells maintain their proper shape,» said Athena Lin, graduate student at the University of California, San Francisco, and lead researcher on the project.

Starting in the late 1980s, their labs revealed steps in how the endoplasmic reticulum, the cell's factory for processing secreted and membrane proteins, deals with proteins whose linear sequence of amino acids hasn't folded into a proper 3D shape.

They produced the first report of the EcPlt's active form inside human cells, describing how the chemical environment inside the cell caused the protein to change shape and activate.

To investigate how zebrafish tails take shape, Thisse's team removed some of the presumed pre-tail cells from early - stage embryos, then transplanted them into the middle of another embryo.

Now, a team from Keio University in Japan, working with a researcher at Imperial College London, have discovered that the shape of the epidermal cells combined with their ability to temporarily glue together, may explain how they form this strong barrier.

(Bottom) Plotting the characteristic ellipsoids for each cell by how round they are in the two major cross sections reveals that cells tend to different shapes on different scaffolds — spheres at one extreme, long narrow rods at another.

For example, how quickly do blood cells return to their original shape after being squeezed through narrow capillaries?

The discovery of the shape and binding capability of epidermal cells could explain how skin maintains a barrier even when it is shedding.

However, how cells recover their shape after mechanical loading is still unclear.

Rules for how human cells return to their original shape after mechanical loading.»

But a deeper understanding of how Jagged regulates duct cell formation in livers could shape strategies to help fix these structures to potentially spare the 10 to 30 percent of patients that eventually need a liver transplant.»

«Due to the nature of how a cell nestles among its immediate neighbors, a scientist can now look at cell shapes and make a reasonable guess as to why, and how fast, those cells will migrate, remodel, or invade surrounding tissues.»

Now, findings from Monell reveal that a person's sensitivity to bitter taste is shaped not only by which taste genes that person has, but also by how much messenger RNA — the gene's instruction guide that tells a taste cell to build a specific receptor — their taste cells make.

In future, Gilmour and colleagues would like to understand the interplay between the ability — or decision — to stop and signals that they previously found drive cells to move forward, and how both are influenced by changes in cell shape.

Although it's not yet known whether regulatory T cells undergo the same conversion in humans, the finding gives a clearer picture of how diet and the immune system interact to shape cardiovascular risk.

By applying biophysical techniques to elucidate the overall shape of ALC1 and combining these approaches with cell - based and live - cell imaging experiments, the authors of the article in Molecular Cell dissect the molecular mechanisms how the remodeling activity of ALC1 is controlled by its macro domcell - based and live - cell imaging experiments, the authors of the article in Molecular Cell dissect the molecular mechanisms how the remodeling activity of ALC1 is controlled by its macro domcell imaging experiments, the authors of the article in Molecular Cell dissect the molecular mechanisms how the remodeling activity of ALC1 is controlled by its macro domCell dissect the molecular mechanisms how the remodeling activity of ALC1 is controlled by its macro domain.

These changes in chromosome shape then affect how the cell divides and how genetic information is passed on to new cells.

This visualization shows tightly - packed DNA in a mouse cell's nucleus at different stages of development, seen here in a semi-triangular form as a mature nerve cell; in a roundish shape as a multipotent stem cell; in a more oval form as a neuronal progenitor; and as a more fragmented structure that shows how removing a specialized binding protein (HP1β knockout) affects the structure of the DNA - packing material, called heterochromatin, in a mature neuron.

Various disease states are associated with deregulation of how cells move and change shape, including notably tumor initiation and cancer cell metastasis.

For over a century, distinctions between types of cells relied on how they appeared under a microscope: their shapes, sizes, locations and their uptake of staining dyes.

Here, experts from around the world — convened by Wellcome, the Wellcome Trust Sanger Institute and the Broad Institute of MIT and Harvard — met to discuss how to shape the Human Cell Atlas.

Learn how loss of certain proteins makes prostate cancer cells able to change shape, migrate, and invade other tissues.