In a new study published in Molecular Psychiatry the researchers describe
how cells from patients with the severe developmental disease lissencephaly differ from healthy cells.
Not exact matches
In the March 22 online issue of Cancer Research, scientists explained
how they injected triple negative breast cancer stem
cells from patients into mice.
Beginning in the 1970s, physicians learned
how to harvest skin stem
cells from a
patient with extensive burn wounds, grow them in the laboratory, then apply the lab - grown tissue to close and protect a
patient's wounds.
To uncover
how this resistance occurs, Guo and Lu teamed with Xu, Herlyn and colleagues examined both
cell lines and tumor biopsies
from melanoma
patients before and after either BRAF inhibitor therapy or BRAF / MEK inhibitor combination therapy.
The researchers isolated bacteria
from the tumors of pancreatic cancer
patients and tested
how they affect the sensitivity of pancreatic cancer
cells to gemcitabine, a chemotherapy drug.
And it suggests that stem
cells derived
from embryos should remain the primary reference for iPS
cells when researchers want to compare
how cells from diseased
patients behave, says Nissim Benvenisty of Hebrew University of Jerusalem, who has studied differences between ES
cells and iPS
cells derived
from carriers of fragile X syndrome.
Their approach is to combine the study of
cells isolated
from TB - infected
patients with micro-engineering in 3D in the laboratory to investigate
how TB damages the lungs.
By examining the
cell cultivation dishes, the researchers were able to observe
how the
patients»
cells behaved and developed
from stem
cells to nerve
cells and compare them with
cells from healthy controls.
Since the 1970s tissue engineers have been figuring out
how to grow skin, bone, cartilage, and even parts of vital organs using
cells harvested directly
from patients.
But neither data
from brain scanners — functional magnetic resonance imaging — nor clinical studies of
patients with implanted electrodes have explained exactly
how the
cells in these face patches work.
How should we regulate treatments that use
cells taken
from a
patient's own body?
Researchers at MIT have now shown that they can use a new type of measurement to predict
how drugs will affect cancer
cells taken
from multiple - myeloma
patients.
They will study human macrophages and dendritic
cells isolated
from IBD
patients with defective GM - CSF function, «The approach represents a step forward in personalizing
how we treat
patients with IBD,» said Dr. Colombel.
To understand
how the different alleles influence the immune response to vaccination, the researchers next looked in more detail at immune
cells from 47 of the
patients (34 had two major T alleles, and 13 had at least one minor G allele).
For the first time, researchers have been able to grow, in a lab, both normal and primary cancerous prostate
cells from a
patient, and then implant a million of the cancer
cells into a mouse to track
how the tumor progresses.
Although this human Gut Chip recreated the villus epithelium of normal intestine and enabled new insights into
how flow and cyclic peristalsis affects intestinal differentiation and function, it could not be used to study processes that relied on normal intestinal
cells from individual donors, which, for example, is crucial for studying
patient - specific responses for personalized medicine.
More recently, physicians have learned
how to harvest blood - forming stem
cells from a donor's blood and transplant them into a
patient, sidestepping the need for an operating room and a needle stick into the pelvis to extract bone marrow.
Knowing the origin of each
cell and which genes control their normal function are the foundations for scientists to decipher the disease process and eventually to find out
how to guide the
cells to self - repair or even to build up a brand new organ using amended
cells from the
patients.»
Since three of the
patients that the
cells were collected
from had responded well to lithium, and three others hadn't seen lithium help their mood swings, the researchers next tested
how the
patient cells reacted to lithium.
Helping to protect newborns and older
patients against more severe effects of jaundice is the hope of University of Guelph researchers, who have shown
how a liver enzyme protects
cells from damage caused by the condition.
Watching
how stem
cells (derived
from ALS
patients» own skin
cells, for example) develop into motor neurons will offer new insights into disease processes, and any method that improves the speed and efficiency of generating the motor neurons will aid scientists.
A study led by scientists
from Harvard Medical School reveals «hidden» variability in
how tumor
cells are affected by anticancer drugs, offering new insights on why
patients with the same form of cancer can have different responses to a drug.
Next steps include He's collaboration with Piedmont Atlanta Hospital to retrieve T
cells, liver cancer
cells and healthy tissue normally removed
from patients during surgery, put the mouse receptor genes on these T
cells and monitor in a dish both
how those
cells now fight the tumor and react to healthy human tissue.
Here, Anna presents
how studies of neural stem
cells and neurons derived
from iPS
cells of
patients show faithful mimicking of known disease phenotypes in our cellular models of disease, like Alzheimer's disease, autism, and Down syndrome.
We are investigating
how tumour
cells can disseminate
from the primary tumour and remain alive but clinically undetectable for many years, and
how they start expanding into life threatening cancers in some
patients.
To that end, Sharma gave an overview of MD Anderson's efforts to comprehensively characterize the activity of the immune
cells in the
patients they treat, and they've already analyzed over 42,000 tumor tissue samples,
from both before and after treatment, looking for clues regarding
how treatment outcomes relate to immune
cell infiltration into tumors.
One of the first clues pathologists look for in tissue
from a newly diagnosed breast cancer
patient is the estrogen receptor, a nuclear protein that converts hormonal messages in the bloodstream into instructions for the
cell about
how to behave.
What is potentially even more revolutionary is
how cells from an individual
patient can be seeded into the chips, opening up new possibilities for personalized medicine.
We accept referrals
from physicians as well as inquiries
from patients diagnosed with CAD, and of course welcome calls and questions
from both physicians and
patients about cardiac stem
cell therapy and
how the treatment is performed.
The knowledge about
how this cancer form arises and develops is still limited but new results
from a research team led by Lene Uhrbom, Uppsala University / SciLifeLab, shows that disease progress and the malignancy are affected by the
cell type
from which the tumor originates as well as the age of the
patient.
Lanza's team figured out
how to coax stem
cells taken
from human embryos into becoming the RPE
cells that die off along with photoreceptors in macular degeneration, and in 2011 the team began injecting these manufactured
cells into
patients» eyes.
Our physicians and scientists are working on a number of initiatives, including collecting blood and bone marrow
from patients to better understand the causes of bone marrow failure syndromes and MDS; exploring possible genetic factors that guide medical care; collecting blood and bone marrow to identify specific proteins that are faulty and
how these defects relate to clinical complications and outcomes; and clinical trials to improve stem
cell transplants for disorders such as dyskeratosis congenita.
Complementing the work of my colleagues in the Roddenberry Center for Stem
Cell Biology and Medicine at Gladstone, our efforts to learn more about
how the heart forms can improve methods for creating heart
cells from stem
cells, either in a petri dish or inside a
patient after a heart attack.
How tumor
cells gain resistance and / or avoid these therapies and which
patients may benefit
from these treatments is currently unknown.
In today's episode, Brian shares his own story and those of
patients who have benefited
from this therapy, along with the science behind why saunas work:
how near - infrared incandescent light exposure stimulates the
cells so that they can repair themselves, and allows the body to detox.
How do I handle requests for such references?Thank you so much for your help!CherylCHERYL M. EARLE3407 Old Dobbin Road, Montgomery, Alabama 36116 - 1903Home Phone: 334-215-3706
Cell Phone: 334-233-2631 Fax: 334-273-0477 E-mail:
[email protected] position managing legal discovery and document review with opportunity to assist attorneys with civil litigationBAR ADMISSIONAlabama State Bar, 1999LAW - RELATED EXPERIENCELaw Firm, AlabamaResearch Attorney for Special Projects, Mass Torts Department, November 2001 — February 2008 • Managed Multi-District Litigation (MDL) Document Depository (September 2002 to February 2008) o Reviewed more than 1 million pages of evidentiary documents for litigation purposes and for inclusion in electronic databaseso Coordinated document review assignments with attorneys at local depository and at other sites across the USo Retrieved, reviewed and coded documents in Concordance and Summation legal databaseso Prepared memoranda and spreadsheets providing detailed analysis of discovery materials • Aided attorneys and support staff with processing and preparation of personal injury claims and litigationo Conducted legal research and drafted pleadingso Conducted supplementary online research for additional documents and information pertinent to litigationo Assisted with preparation of correspondence to clients and referring attorneyso Contacted clients for additional information needed in case preparation, litigation, and potential settlementso Prepared and input case intakes and referrals into databaseLaw School, AlabamaStudent Intern, Alabama Disabilities Advocacy Program (ADAP), August 1996 — June 1997 • Participated in law school clinical program under third - year law student practice rule (as authorized by Alabama Supreme Court) o Assisted attorneys and advocates in cases involving mentally ill
patients confined to state mental health facilitieso Interviewed clients in person (at state facilities) and over the phoneo Worked with clients, attorneys, and social workers to investigate and resolve issues concerning involuntary confinement and treatmento Aided in legal research on an appellate brief submitted to the U. S. Court of Appeals for the Eleventh Circuit (ruling granted in favor of our client) Faculty Research Assistant for Library Services, Bounds Law Library, March 1996 — June 1997 • Prepared research and teaching materials for law school faculty; worked 20 hours per week while matriculating 10 - 15 hours per semester) o Investigated copyright issues related to procuring and reproducing texts for academic useo Conducted legal research using WESTLAW, LEXIS and the InternetADDITIONAL RELEVANT EXPERIENCEManufacturing Company (MC), Montgomery, AlabamaAdministrative Assistant and Cost Analyst, Materials Purchasing Department, April 1999 — September 2001 • Assisted materials buyers in negotiating and preparing commodities contracts between raw materials suppliers and MC for manufacturing plants in the US and Mexicoo Assisted Legal Department at MC's corporate headquarters with coordination and preparation of documents for litigationo Notified and educated suppliers about MC's freight - on - board policy and its corresponding Uniform Commercial Code (UCC) provisions; result was the reduction of freight claims for both the company and its supplierso Prepared contracts and purchase orders for raw materials and capital projects involving plant maintenanceo Solicited price quotations
from current vendors and established Excel spreadsheet format which simplified quote submission process and allowed MC to track and compare usage volumes and costs over timeo Prepared and analyzed cost reports used by materials buyers and production planners in purchasing decisions, including cost reductions, materials consolidation, and selection of vendorso Acted as liaison between vendors and the Purchasing, Transportation and Accounting Departments on issues concerning inbound freight, commercial carriers, and payment terms for commodities, resulting in reductions in freight costs and greater payment discounts for raw materialso Established online databases and printed directories for the Purchasing Department, allowing buyers to have easier and faster access to current vendor informationo Completed Year 2000 (Y2K) compliance project, which involved data collection and communication with MC's past, present, and potential materials suppliers and service providersNot - For - Profit Organization, AlabamaAdministrative Assistant, Combined Federal Campaign, September 1998 — January 1999 • Aided Campaign Director with 1998 Federal Campaigns (CFCs) in City 1 and City 2, which together generated nearly $ 700,000 for more than 1,000 local, national and international charitieso Prepared weekly reports on donations using WordPerfect, Microsoft Word, Excel and dBase IVo Wrote script for Talent Showcase at City 1's 1998 CFC Kickoffo Assisted Director with merger of the City 1 and City 2 CFCs in 1999Regional Bank, AlabamaAdministrative Assistant, Year 2000 (Y2K) Department, March — June 1998 • Worked with Vice President of Corporate Projects on short - term project for the bank's Y2K Departmento Analyzed and processed data on Y2K readiness for all branches of Bank throughout the southeastern USo Organized meetings for personnel of Banko Communicated with vendors of computer hardware, software, and office equipment to request information on Y2K complianceo Prepared compliance files for Federal Reserve auditso Prepared in - house memoranda and reports using Microsoft Word and ExcelRecord / Music Promotion Company, AlabamaRecord Pool Co-Founder; Office Manager, September 1990 — December 1991 • Co-founded record pool to enhance promotion of music in Alabama and the southeastern USo Procured and distributed records
from major and independent labels for club, radio and mobile disc jockeyso Coordinated jointly sponsored promotional events with record companies, radio stations and clubso Designed, wrote, and published bi-weekly reports and brochures to inform the music industry of the progress and popularity of music and performers in the region, with specific focus on the Alabama music sceneMajor University, AlabamaGraduate Research Assistant, AUM Department of Marketing, June 1989 — August 1990 • Worked 13 - 20 hours per week as a research assistant to Marketing faculty while carrying a full course load in the MBA programo Analyzed consumer surveys used in academic researcho Assisted Conference Chairperson with coordination for Atlantic Marketing Association (AMA) annual meeting (October 1989) o Co-authored five - year index and classification of AMA Proceedings (published Fall 1991) EDUCATIONLaw School, AlabamaJuris Doctor (JD), 1997 • Scholarshipso Seybourn H. Lynne Scholarship, 1996 - 97o Dexter C. Hobbs Memorial Scholarship, 1995 - 96o E. W. Godbey Memorial Scholarship, 1994 - 95 • Honorso Who's Who Among American Law School Students, 1996 - 94o Arthur Davis Shores Award, 1997 • Activitieso Frederick Douglass Moot Court Team Manager, 1996 - 97 Southern Regional Competition, Second Place National Competition, Eighth Placeo John A. Campbell Moot Court Competition, Spring 1996o Black Law Students Association Delegate, BLSA National Convention, 1997 Co-Chairperson, Public Relations Committee, 1996 - 97 Chairperson, Public Relations Committee, 1995 - 96 BLSA President's Award, 1996 and 1997o American Bar Association, 1996 - 97 Entertainment and Sports Industries Forum Intellectual Property Section Law Student Divisiono LAWS Student Group Leader, 1995 - 96Major University, AlabamaMaster of Business Administration (MBA), 1990Bachelor of Science in Business Administration (B.S.B.A.), 1988 (Major: Marketing — Advertising and Promotion Track) • Honorso Dean's List • Activitieso National Student Advertising Competition Team, 1988 - 90 Seventh District Competition: Third Place, 1990o Marketing Club, 1987 - 90 Vice President — Career Development, 1988 - 89o Public Relations / Advertising (PR / AD) Club, 1988 - 90 Charter Member, 1988 Active in fund - raising and membership driveso Theater Guild, 1988 - 90 Screening Committee, 1989REFERENCESAvailable upon request