What could medicine look like someday if, instead of focusing primarily on the organ affected by a disease — neurologists examining brain diseases, pulmonologists focusing on lung diseases — our system was centered on
how cells process energy?
«We know that the pathway is important for normal cells to carry their activities as it is involved in regulating metabolism, that is,
how cells process nutrients to obtain energy and how cells use energy to grow.
Not exact matches
Conversely, if God is seen primarily as the expressed psychicalization in
process of a multiplicity of event -
cells,
how can there be anything more than just that: psychicalized event -
cells?
The second question has in fact two facets: (a)
how does it arise in the development of the individual organism during the
process of growth from the moment of fertilization of the egg; and (b)
how does the egg itself come to get that way — that is to say,
how can we conceive of evolution as having «designed» the
cell?
You will see a pictorial expression of fertilization
processes;
how the sperm
cell swims to an ovary and clings to it, then within some weeks a fetus looking like a tadpole is formed.
It goes beyond the structure of life and gets to biological
processes, including
how cells or molecules move,
how cells respond to their environment or neighbors, and
how the brain works or
how injuries heal, he says.
Joe W. Ramos, PhD, deputy director of the UH Cancer Center and collaborators focused on investigating
how these oncogenes and related signals lead to dysregulation of normal
processes within the
cell and activate highly mobile and invasive cancer
cell behavior.
Therefore, it is essential that we learn
how specific types of chemical modifications normally regulate RNA function in our
cells, in order to understand
how dysregulation of this
process contributes to human disease, says Cristian Bellodi.
By measuring
how the light has changed once it emerges through the other side of the slide, the researchers can detect and monitor
processes occurring on the sensor surface, such as
cell division.
However, it remains unclear
how these different stem
cells populations balance proliferation, differentiation and migration during the healing
process.
To investigate
how the egg
cell manages to rid itself of such a resilient structure, Joana Pinto, a PhD student in the Lénárt lab, developed fluorescent tags for mother and daughter centrioles in a starfish egg
cell and recorded the entire
process of eliminating them.
Researchers then tested
cell cultures and mouse models by using a gene editing
process called CRISPR - Cas9 to demonstrate
how the presence or absence of myomaker and myomerger — both individually and in unison — affect
cell fusion and muscle formation.
Over the past 15 years, the GFP gene has enabled scientists to watch a plethora of previously murky biological
processes in action:
how nerve
cells develop in the brain,
how insulin - producing beta
cells form in the pancreas of an embryo,
how proteins are transported within
cells, and
how cancer
cells metastasize through the body.
One area of research within mechanobiology, the study of
how physical forces influence biological
processes, is on the interplay between
cells and their environment and
how it impacts their ability to grow and spread.
Knowing
how these
cells mature during development might lead to a better grasp of just
how to replicate that
process in the adult brain, which could eventually pave the way to strategies that rejuvenate aging circuits, Donato said.
This study provides a breakthrough in our understanding of
how information
processed in the amygdala — one
cell at a time — maintains the delicate balance between whether one should or should not be afraid.
«Knowing
how cells respond to mechanical cues in the living embryo and
how they physically sculpt tissues and organs in the 3D space will transform the way we think about developmental
processes,» said Otger Campàs, a professor in the Department of Mechanical Engineering at UCSB and senior author on the paper that reports this novel technique in Nature Methods.
Meanwhile, recent human studies indicate that aging is associated with an increase in somatic mutations in the hematopoietic system, which gives rise to blood
cells; these mutations provide a competitive growth advantage to the mutant hematopoietic
cells, allowing for their clonal expansion — a
process that has been shown to be associated with a greater incidence of atherosclerosis, though specifically
how remains unclear.
While these results suggest that boosting autophagy in the gut is generally beneficial, Hansen cautions that further research is needed: «Before we can consider regulating autophagy to manage disease, we need to learn a lot more about
how the
process works both in a single
cell as well as in the whole organism.»
«With this discovery in our hands, we'd now like to try to find out which additional immune -
cell properties cancer
cells have and study
how they affect the metastatic
process,» says Dr Fuxe.
«We want to start looking system by system to see
how widely acting this
process is on different types of
cells,» he says.
«Tropical trees, compared those in temperate forests, have three times as many living
cells surrounding the xylem that can facilitate these
processes, which are not observed by the typical experiments we conduct to determine
how vulnerable a plant is to droughts.»
«This is what we need to find out next, because it could provide some clue as to
how we could activate the same
process in human
cells.»
«It takes about one hour for the virus to complete the
process, but questions remain about
how the
cells control this precision in timing.»
Researchers are using the sea hare model to learn about individual
cells function, discover the chemical pathways controlling various brain activities and to study
how memories are
processed and stored.
It's not that they're trying to block the
cells from transforming into iPSCs, but they've simply never been exposed to this
process before and don't know
how to react.»
In their report published in Science Immunology they describe
how expression of a specific molecule — complement C5a — is required to cause the immune
cells called neutrophils to adhere to joint surfaces and migrate into the joint, a
process known to set off the inflammatory cascade.
And it's essential to understand
how neurobiological
processing conducted by molecules and
cells and electrical signaling gets translated into behaviors, from simple bodily movements to complex social interactions.
«In order to simulate the oil recovery
process we divide the reservoir up into small segments or
cells and describe
how the oil migrates from
cell to
cell.
Despite all they have learned in the past century, neuroscientists have made little headway in figuring out exactly
how brain
cells process information.
But it is never clear by what
process these
cells are formed or
how similar they are to the natural versions.
A
process that wipes egg and sperm
cells clean misses some genes out, explaining
how your bad habits may affect the DNA of your children and grandchildren
To understand defective disease
process, investigators need to track where and
how transcription factors bind to DNA to identify the differences between healthy and diseased
cells.
In their efforts to conquer the aging
process, researchers are zeroing in on one specific part of the
cell: mitochondria, the energy - generating organelles that control our metabolism and, it seems, help regulate
how long we live.
Previously it was unknown
how this
process works, but now scientists at Karolinska Institutet have discovered the importance of particular protein rings encircling the DNA and
how these function as the
cell's memory.
This
process is
how dsRNA silences genes in a
cell.
mTOR controls a
process that determines
how large our
cells are and
how many
cells we have.
«But mounting evidence confirming angiotropism and EVMM has revolutionized the knowledge of
how cancer spreads through the body to the point that other scientists have confirmed the
process in other solid tumor
cell types such as pancreatic cancer.»
In contrast, says Kawauchi, the new findings help explain
how p53 affects the cytoskeletal
processes within the
cell that drive invasion.
Scientists produced an artificial chromosome in the lab to investigate
how cells renew themselves — a
process known as
cell division.
How cell division occurs and is coordinated with organismal development is a subject of intense research interest, as is how this process malfunctions in the development of tumo
How cell division occurs and is coordinated with organismal development is a subject of intense research interest, as is
how this process malfunctions in the development of tumo
how this
process malfunctions in the development of tumors.
«All the
cells looked the same and you had no idea when or
how the
process occurred.
A new study from The Scripps Research Institute (TSRI) is the first to show precisely
how a
process in nerve
cells called the S - nitrosylation (SNO) reaction — which can be caused by aging, pesticides and pollution — may contribute to Parkinson's disease.
Understanding
how cancer
cells are able to metastasize — migrate from the primary tumor to distant sites in the body — and developing therapies to inhibit this
process are the focus of many laboratories around the country.
The researchers also discovered an essential role for the mechanical properties, i.e. the physical stiffness, of the gel in regulating intestinal stem
cell behavior, shedding light on
how cells are able to sense,
process and respond to physical stimuli.
Understanding this
process - which is particularly important when
cells are first taking on specialized identities such as nerve
cells, muscle, skin, and so on - helps explain
how complex organisms can arise from a finite number of genes.
But
how the
process worked — and even which
cells used the method — was unclear.
Further studies showed that very similar genes controlled the
process in animal and human
cells, and also helped piece together
how the genes work together to keep the
cell's recycling centers running.
«We wanted to understand
how the monarch is
processing these different types of information to yield this constant behavior — flying southwest each fall,» said Shlizerman, who is lead author on the team's recent paper in the journal
Cell Reports.
At that time, little was known about the molecular biology of development —
how what's going on in the development
process itself influences what can happen to the evolutionary trajectory of
cells and organisms.