«With our colleagues at UC San Francisco, we will create single - cell tools to map
how cellular components connect into circuits,» said the center's director, Leor Weinberger, PhD.
The Gladstone Center for Cell Circuitry (GC3) addresses this fundamental challenge by developing single - cell tools to map
how cellular components connect into circuits.
The center creates single - cell tools to map
how cellular components connect into circuits.
Not exact matches
Ribosomes, the
cellular factories that manufacture proteins, contain both RNA and protein, but exactly
how all of the different ribosomal
components contribute to protein synthesis is still not clear.
Their main aim is to understand
how mitochondria interact with other
cellular components to maintain physiological homeostasis, and
how mitochondrial defects lead to pathological states.
To find out why, computational biologists came up with a computer model to predict
how microbial metabolism and
cellular composition change as cell size varies, using details about
how much space a bacterium needs for its
components — DNA, proteins, and the molecular factories called ribosomes — to function.
The research team has been using NMR — a technique related to the one used in MRI body scanners and capable of visualising molecules at the smallest scales — to examine
how small
components of herpes virus help it to multiply by binding themselves with other large molecules; this produced images of a monkey herpes virus protein interacting with mouse
cellular protein and viral RNA.
While previous research had shown that TTLL7 modifies microtubules (hollow tubes that transport
cellular components and act as highways and scaffolding in the cell) by adding one or more molecules of the amino acid glutamate, exactly
how has remained a mystery.
Although some of the key molecular
components involved in the formation of
cellular structures and tissue formation are known, we currently lack a bottoms up understanding of
how the behavior of these molecules gives rise to the formation of large structures, partly because of the lack of tools for both studying the spatial regulation of soluble proteins and biophysically characterizing the behavior of large structures and tissues.
The BioVacSafe project will draw on the latest life science research findings to profile
how individuals respond to the different
components of vaccines at the
cellular, genetic and molecular level.
One major goal is to unravel
how the self - organization of
cellular components results in the morphogenesis of dynamic molecular machines.