Sentences with phrase «how cellular proteins»

As a basic researcher, he has been most interested in looking for ideas that point toward new directions in the field: a new role for a protein or a new understanding of how cellular proteins drive the immune response.

UCLA scientists have uncovered how a cellular protein contributes to an aggressive form of leukemia prevalent in young children.

Not exact matches

Actually, science has been able to show how the very first proteins and cellular organism did evolve from non-life.

Ribosomes, the cellular factories that manufacture proteins, contain both RNA and protein, but exactly how all of the different ribosomal components contribute to protein synthesis is still not clear.

Allan Jacobson, Ph.D., of the University of Massachusetts Medical School and co-founder of PTC Therapeutics, the company that developed ataluren, and David Bedwell, Ph.D., professor of the UAB Department of Biochemistry and Molecular Genetics, have sought to understand precisely how ataluren allows the ribosome, the machinery of cellular protein synthesis, to skip over these inserted stop signs and produce proteins that have normal or near - normal function.

They used this novel simulation approach to build a model of a sperm cell that demonstrates cellular movement from individual dynein protein molecules in the tail all the way up to the whole cell, allowing them to observe how changes at the atomic level are reflected in larger - scale structures.

In their study, the Salk scientists sought to determine precisely how the mutated WRN protein causes so much cellular mayhem.

However, it was unclear exactly how the mutated WRN protein disrupted these critical cellular processes.

However, the researchers found that a well - known cellular mechanism — one that controls how proteins acquire new functions — also plays a major role.

To find out why, computational biologists came up with a computer model to predict how microbial metabolism and cellular composition change as cell size varies, using details about how much space a bacterium needs for its components — DNA, proteins, and the molecular factories called ribosomes — to function.

New work led by Carnegie's David Ehrhardt hones in on how one particular organizational protein influences cytoskeletal and cellular structure in plants, findings that may also have implications for cytoskeletal organization in animals.

The research team has been using NMR — a technique related to the one used in MRI body scanners and capable of visualising molecules at the smallest scales — to examine how small components of herpes virus help it to multiply by binding themselves with other large molecules; this produced images of a monkey herpes virus protein interacting with mouse cellular protein and viral RNA.

The laboratory of Marcos Malumbres, who is head of the Spanish National Cancer Research Centre's (CNIO) Cell Division & Cancer Group, working alongside Isabel Fariñas» team from the University of Valencia, shows, in a study published today in the journal Nature Communications, how in mice the elimination of the Cdh1 protein — a sub-unit of the APC / C complex, involved in the control of cell division — prevents cellular proliferation of rapidly dividing cells.

This study reveals how lipids control SH2 domain - mediated cellular protein interaction networks and suggests a new strategy for the therapeutic modulation of pY - signaling pathways.

Now scientists have a clearer view of how ISRIB works — by pinning together parts of a protein involved in cellular stress.

«The longer we study these classes of proteins, the clearer it becomes how adept these molecules are at interfering with cellular growth to such an extent that makes normal control virtually impossible,» says Prof. Slany.

Now, researchers at the University of Missouri have developed a three - dimensional microscope that will yield unparalleled study of membrane proteins and how they interact on the cellular level.

The team of researchers uncovered the molecular basis of the interaction between these proteins, and how TACC3 recruits chTOG to the microtubules during cellular division.

They've learned how the super-strong and mega-long protein threads secreted by the eel - like animals are organized at the cellular level.

During the early years of my PhD studies, I was very fascinated by the exciting discoveries in the field of signal transduction, in particular how receptor tyrosine kinases are activated to transmit their signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.

Now one team, reporting in the journal ACS Chemical Neuroscience, has identified how amyloid beta, the protein fragment strongly associated with Alzheimer's disease, can induce cellular changes that might lead to Parkinson's.

But until he understands how the cells are stressed in the first place, he won't know much: «We frankly don't have a clue as to how much microwave radiation is needed to cause irreversible damage to cellular proteins.

So far, we know that aspirin inhibits the production of proteins known as prostaglandins, which help control the cellular communication that controls how cells proliferate.

Although some of the key molecular components involved in the formation of cellular structures and tissue formation are known, we currently lack a bottoms up understanding of how the behavior of these molecules gives rise to the formation of large structures, partly because of the lack of tools for both studying the spatial regulation of soluble proteins and biophysically characterizing the behavior of large structures and tissues.

Salk researchers show how DNA repair proteins distinguish DNA breaks at cellular and viral genomes to activate an appropriately scaled response.

When Walter arrived in Blobel's lab as a fresh - faced apprentice, Blobel and his colleagues had limned the outlines of the so - called signal hypothesis, which purported to explain how proteins, which are made in cellular machines called ribosomes, find their pre-destined locations within cells.

Finally, in a collaboration with Frank Jülicher's group at the Max Planck Institute for the Physics of Complex Systems, we are using these data to develop physical models that will help us understand how local cellular adhesive, elastic and contractile properties are influenced by PCP proteins and other molecules, and how they combine to produce specific packing geometries at a global level.

The Sarma laboratory is interested in the mechanisms of epigenetic gene regulation, or how the dynamic modifications of the architecture of chromatin, the complex of DNA and proteins within the nucleus of our cells, impacts gene expression and cellular function.

Beyond the internal interactions of the protein itself, these designed oligomers can be used to explore basic questions about how the structure of signaling molecules affects the behavior of receptors and cellular response.

Previously a distinguished professor in the University of Minnesota's Department of Biochemistry, Molecular Biology and Biophysics, Kalodimos» research into the cellular machinery relevant to cancer has led to important insights into how mutated proteins can drive the development and spread of the disease.

In the study, the researchers describe the microscopic physical interactions and chemical changes of proteins associated with several cellular functions, including disease forms, and how still - healthy cells could try to temper it.

The study that will be published in the March 21 issue of the science magazine Cell describes how insulin, through the activity of an enzyme recently described by the Freiburg research team, blocks one of the most important cellular stress regulators, a protein called SKN - 1.