Sentences with phrase «how changes in sequence»

A high resolution description of the structure and dynamics of proteins is a very useful tool to study the properties and the function of these important biomacromolecules and, most importantly, to understand how changes in sequence or environment can lead to disease.

Not exact matches

[1:20] How the kindness of a stranger changed Tony's life [3:35] Peter Diamandis talks about the origins of X Prize [6:30] Technology helping the agricultural industry [7:00] Sequencing genomes [8:55] Life - work integration [11:15] Finding your highest calling in life [12:00] Reframing what is «impossible» [14:00] Strategy vs. psychology [15:00] Changing your state [16:00] The science of achievement, the art of fulfillment [19:00] Living in a beautiful state [24:00] Thinking 10x bigger [28:00] Surrounding yourself with a «nothing is impossible» community [29:00] The news pollutes your mind [31:00] Tony's natural gifts and core beliefs [33:30] Overcoming failure and criticism [37:45] Defining your environment [40:00] Life happens for you, not to you [42:00] Rituals and practices to up your game [46:30] Tony's priming process

At DiscoverOrg, this might take the form of a data enrichment and matching exercise, a custom buildout to support changes in a go - to - market strategy, or something as simple as a workshop on how to overcome email deliverability issues or how to write email sequences for a drip campaign.

Understanding our own and our children's sequencing patterns can change how we connect in very profound ways.

The new analysis, based on data assembled primarily by graduate student Yan - Jie Feng at Sun Yat - Sen University in Guangzhou, China, focused on the sequences of 95 genes located on chromosomes in the nucleus and how they changed over time.

We used massively parallel viral sequencing to understand how and when EBOV entered human populations in the 2014 West African outbreak, whether the outbreak is continuing to be fed by new transmissions from its natural reservoir, and how the virus changed, both before and after its recent jump to humans.

Researchers at Umeå University show in a new, detailed structural study, published in the journal Nature Communications, how the binding of the signal - sequence triggers a number of structural changes within the SRP particle.

They have since collected chloroplast sequence data from six different plant species that spread their seeds in a variety of ways, and will use CallHap to investigate how their seed dispersal methods might perform in response to climate change.

The work, made possible by powerful advances in genetic sequencing and a 45 - year data set, has revealed how the jay's environment has favored small changes within the genome.

I'm keen to find out the precise sequence of changes to OLs and myelin during learning and whether these changes are needed more in some parts of the brain than others, which might shed light on some of the mysteries still surrounding how the brain adapts and learns throughout life.»

Steve: The changes were in those other sequences that determine how those genes get expressed, when they get turned on and off and in what numbers.

«The computational approach allows us to model, right down to the atomic level, how small changes in protein sequence can have a major impact on signaling,» said MacDermaid, assistant professor of research at Temple's Institute for Computational Molecular Science.

To better understand how changes in diet, lifestyle, and exposure to modern medicine affect primates» guts, a team of researchers used DNA sequencing to study the gut microbes of multiple non-human primates species.

To better understand how changes in diet, lifestyle, and exposure to modern medicine affect primates» guts, a team of researchers led by University of Minnesota computer science and engineering professor Dan Knights, veterinary medicine professor Tim Johnson, and veterinary medicine Ph.D. student Jonathan Clayton, used DNA sequencing to study the gut microbes of multiple non-human primates species in the wild and in captivity as a model for studying the effects of emigration and lifestyle changes.

«Advances in genetic sequencing technologies now allow us to find patterns in large, diverse populations of microorganisms, see how they associate with specific individuals, and understand how they change over time in a way we couldn't just a few years ago,» said Knight, who leads the UC San Diego Microbiome and Microbial Sciences Initiative.

This includes how subtle changes in gene sequences can impact the expression of encoded proteins through mechanisms including codon bias, mRNA stability, and translation initiation.

But because the vinclozolin - induced fertility changes occurred in almost every male rat descended from a treated mother rather than in a small percentage of offspring (as is seen in germ line mutations caused by radiation), Skinner suspects an epigenetic mechanism — a change that doesn't mutate the DNA sequence of an animal, but rather affects how genes are expressed.

In the current study, the authors used single - cell RNA sequencing (RNA - Seq) to monitor how individual cells change when they are combined in a three - dimensional (3D) microenvironmenIn the current study, the authors used single - cell RNA sequencing (RNA - Seq) to monitor how individual cells change when they are combined in a three - dimensional (3D) microenvironmenin a three - dimensional (3D) microenvironment.

In answer to the first question, we analyze how the mode of drug resistance evolution changed within patients throughout the epidemic using historical HIV sequences.

«The human genome sequence provided a blueprint of all the protein - coding genes in the human genome for the first time,» reveals Jan Ellenberg, Head of the Cell Biology and Biophysics Unit at EMBL Heidelberg, «this changed how we go about studying protein function.»

Since the completion of the human genome and beginning with the rise of next - generation sequencing, our community has seen some important changes in how we conduct research.

Researchers found that particles in exhaust from cars and trucks can cause epigenetic changes — alterations that affect how genes are switched on and off without changing the DNA sequence itself.

They also investigate how these interactions change in melanocytes depending on a combination of factors, including an individual's unique DNA sequence, DNA mutations that arise in a cell over time or due to environmental exposure, and the signals that are present in a cell's surrounding micro-environment.

He is investigating both how the genome is packaged, protected, sequestered, and made accessible within the cell nucleus, as well as how changes in DNA sequence relates changes in structure and function of encoded biological macromolecules.

The event, entitled «Spring Mutations: How Deep Sequencing is Changing Protein Science,» was the first in a series of jointly hosted QBI and Gladstone symposia that will focus on cutting - edge research technologies.

In particular, the lab investigates how alterations in epigenetics — or the heritable changes that affects gene expression without alterations in the underlying DNA sequence — contribute to epithelial ovarian canceIn particular, the lab investigates how alterations in epigenetics — or the heritable changes that affects gene expression without alterations in the underlying DNA sequence — contribute to epithelial ovarian cancein epigenetics — or the heritable changes that affects gene expression without alterations in the underlying DNA sequence — contribute to epithelial ovarian cancein the underlying DNA sequence — contribute to epithelial ovarian cancer.

High - throughput sequencing has fundamentally changed the field of human genetics, particularly in how we study genetic diseases like cancer.

The information gained from genome sequencing can not be «unlearned»: it may change the way you think about your health and the health of your family, who you are, and how you see yourself in the world.

Modern biologists know that DNA controls the inheritance process and that mutations in the sequence are how changes in biology from parent to child are transmitted.

Frieden says they haven't yet seen that in MERS, but they're watching: the CDC is currently sequencing the genome of the virus to understand how it might be changing, and to track its course.

The focus of the conference was connecting how epigenetics (cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence — in other words nutrition and lifestyle choices) impact whether or not an individual actually develops a specific health issue even though they have a SNP mutation.

As we learn more about the makeup of good and bad bacteria in the gut biome, researchers are also doing cutting edge DNA microbiome sequencing to show how people's gut biomes are changing on a population level.

He trusted her, and she could argue with him; she knew his rhythms, the pace of the long shots, dialogue and action, how to adapt to changes in tone, sequence by sequence.

There are some wonderfully clever uses of VR, including one sequence where the player looks at «themselves» in the mirror and the face subtly changes expression, based on how they adjust their Rift.

During the fun conversation Bonneville joked about how Grant has changed since making Notting Hill, when they knew the sequel would be such a special film, what it was like filming the big train chase sequence in the 3rd act, and more.

The combination of clever how - to details and wild fantasy is a throwback to the days of Disney's live - action man - against - nature films (only slightly grimmer), but it's flanked by a more down - to - earth depiction of the hero's youth in a zoo - owning Indian family, as well as a closing sequence that changes the meaning of everything that's come before.

For more resources visit thisisgeography.co.uk Lesson sequence: 1 - Urban future 2 - Supersized cities 3 - How cities began 4 - Urbanisation in Africa 5 - Favelas 6 - Urban change in the UK 7 - The future of cities ICT 8 - Introducing Bristol 9 - Social opportunities 10 - Bristol's economy 11 - Urbanisation and the environment 12 - Environmental challenges 13 - Social inequality 14 - New housing in Bristol 15 - The Temple Quarter Regeneration 16 - Rio De Janeiro 17 - Social challenges in Rio 18 - ICT economic challenges in Rio 19 - Improving Rio for the city's poorest

For more resources visit thisisgeography.co.uk Lesson sequence: 1 - Introducing the living world - small scale ecosystems 2 - How change affects ecosystems 3 - Global ecosystems 4 - Rainforests introduction 5 - Causes of deforestation in Malaysia 6 - The impact of deforestation in Malaysia 7 - Managing tropical rainforests (ICT lesson) 8 - Sustainable management in tropical rainforests Hot deserts also on the This is Geography shop to be taught alongside this module.

Puzzles have familiar enough structures to almost immediately clue the player into how to solve them, while the platforming never does change very much from what you see in the opening hour or two, instead just increasing the amount of things you'll need to do in one sequence.

Rail gliding, loop - de-loop segments, and scripted action sequences are placed in the team's way, but the game makes sure to change up how they look as part of the story's «global scale.»

This sequence teaches you how to get in and out of cars, basic driving (gas, break, turning), how to change the radio station in the car, how to pick up passengers, how to get a new car if your current car gets too damaged, and how to use the mini-map to find mission objectives.

How does the temperature profile in the troposphere develop during the sequence of regime changes you describe?

Posted in Advocacy, News, Research Comments Off on Next - generation Sequencing Offers Insight Into How Species Adapt to Climate Change

Teasing out the sequence of events, from the forensic evidence buried in rocks, not only helps scientists to better understand the history of the planet - it can help to suggest how Planet Earth responds to these game - changing pushes.

Epigenetics provides another way of understanding how genes and environment interact in that there is increasing evidence that gene expression is moderated by the environment in which the organism grows and develops.15 Genetic information is encoded not just in DNA linear sequences but in epigenetic changes in chromatin structure such as DNA methylation or covalent modifications of the DNA - binding proteins.

I think that it really flowed in sequence... understanding how the brain functions and how habits are formed is a useful approach to promoting change.