Currently we know very little about
how our circadian clocks interact with viruses at the molecular level.
Using the fruit flies, they showed
how circadian clock neurons use thermoreceptors to constantly monitor the temperature of their environment.
EPFL biologists and geneticists have uncovered
how the circadian clock orchestrates the 24 - hour cycle of gene expression by regulating the structure of chromatin, the tightly wound DNA - protein complex of the cell.
However, very little is known about
how the circadian clock regulates this critical part of gene expression to organize the day - night rhythm of protein expression, and if the formation of this looping changes over the day.
Brooks plans to unravel
how the circadian clock works with the innate immune system to regulate microbe metabolism.
This discovery underscores the widespread importance of p75NTR by offering insight into
how the circadian clock helps maintain the body's overall metabolic health.
Not exact matches
Determining the differences between short and normal period
clocks in spiders may help researchers find out why and
how different
circadian clocks are suited to the particular environmental challenges of each species, Moore said.
With a new $ 2.4 million grant from the National Institutes of Health, LeBourgeois recently launched a study in which she will expose 90 children to light of different intensities to determine
how much it takes to impact the
circadian clock.
The expert is the author of a study published in the «International Journal of Cancer», which reveals the importance of assessing
how the
circadian system works in order to prevent chronodisruption and to implement measures to strengthen the biological
clock in people whose system is damaged.
«What has become obvious over the past few years is that metabolism, all those pathways regulating
how fats and carbohydrates are used, is affected by the
circadian clock,» says biochemist Corinne Silva, a program director at the NIDDK.
«The next challenge is to unravel exactly
how it is involved in allowing C. reinhardtii to reset its
circadian clock when exposed to red or violet light.»
Hollings Cancer Center researchers Dr. Yiwen Bu and Dr. J. Alan Diehl explore
how cancer overrides the
circadian clock to survive.
Scientists are still debating
how and why the
circadian clocks that govern biological timekeeping evolved.
«This year's Nobel Laureates have been studying this fundamental problem and solved the mystery of
how an inner
clock in most of our cells in our bodies can anticipate daily fluctuations between night and day to optimize our behavior and physiology... since the paradigm shifting discoveries by Hall, Rosbash and Young,
circadian biology has developed into a highly dynamic research field with vast implications for our health and well - being.»
LiWang's group discovered that
how the proteins move hour by hour is central to cyanobacteria's
circadian clock function.
Although caffeine's effects on alertness and sleep are well known, researchers weren't sure
how it affects the
circadian clock in humans.
TIMEKEEPERS Three Americans have won the Nobel Prize in physiology or medicine for discovering the gears of
circadian clocks and
how they govern daily rhythms, such as sleep, metabolism and other body processes.
Researchers hit the jackpot this year in understanding
how light resets the
circadian clock, our internal timepiece that regulates daily patterns of behavior and physiology.
On a lark, Hirsh's team decided to examine
how flies with mutated
circadian clocks handle their cocaine.
The Physiology or Medicine Prize recognized work on
how several genes work together to control the basic
circadian clock, encoding proteins that build up during the night and are broken down during the day.
Jeffrey Hall and Michael Rosbash of Brandeis University in Waltham, Massachusetts, and Michael Young of The Rockefeller University in New York City share the prize equally for their work on
how several genes work together to control the basic
circadian clock, encoding proteins that build up during the night and are broken down during the day.
This research is important, however, because it not only shows us what might be going wrong in folks with
circadian - related disorders, but also helps us to understand
how we can manipulate peripheral
clocks to help these people.»
But now, researchers at the Gladstone Institutes have discovered
how one important protein falls under direct instructions from the body's
circadian clock.
However, what was most fascinating, say the researchers, was
how a drop in p75NTR levels then affected a variety of
circadian clock systems.
How does the
circadian clock change when we get older?
This new understanding of
how circadian rhythms are regulated through the eye could open up new therapeutic possibilities for restoring biological
clocks in people who have jet lag through travelling or working night shifts.
In the near future, «The project will go on to tackle metabolism:
how metabolism instructs the
circadian clock to regulate which genes.
This gives an insight into
how the biological
clock is regulated by light and could open up new therapeutic opportunities to help restore altered
circadian rhythms through the eye.
Within this broad topic we are particularly interested in characterising (i) the molecular mechanism by which these photoreceptors mediate light - dependent entrainment of the
circadian clock, (ii) the components mediating, in a light - quality - dependent fashion, nucleocytoplasmic partitioning of phytochromes and UVR8, (iii)
how phosphorylation and sumoylation of these photorecepors and other signalling components modulate red / far - red and UVB - induced signalling, and (iv) to what extent intercellular and cell - autonomous events contribute to phytochrome and UVR8 regulated photomorphogenesis.
We study
how various physiological and molecular processes including physical activity, fat metabolism,
circadian clocks, advanced glycation end products, calcification and intestinal permeability are influenced by nutrients to impact organismal health and survival.
In a recent post, I wrote about the science behind
how blue light can disrupt your body
clock and natural
circadian rhythms potentially leading to a variety of health impacts ranging from insomnia to cardiovascular disease to weight gain to mood imbalances.
Your body's internal
clock (also known as your
circadian rhythm) influences
how much melatonin the pineal gland makes, and so does the amount of light that you're exposed to each day.
Your body's internal
clock (also known as your
circadian rhythm) influences
how much melatonin your body makes, as does the amount of light that you're exposed to each day.
The brain coordinates
how a dog responds to these
circadian rhythms, and a dog's biological
clock — the internal system that controls his everyday activities — allows him to recognize things like sunlight and nightfall and helps him associate certain behaviors, like going outside or eating, with those times of day.