His basic research is focused on understanding
how eukaryotic mRNAs recruit ribosomes, how ribosomes subsequently locate initiation codons, and how ribosomes regulate the translation of specific subsets of mRNAs.
Stephen J. Elledge, Gregor Mendel Professor of Genetics and Medicine in the Department of Genetics at Harvard Medical School and in the Division of Genetics at the Brigham and Women's Hospital and Investigator with the Howard Hughes Medical Institute, for elucidating
how eukaryotic cells sense and respond to damage in their DNA and providing insights into the development and treatment of cancer.
Kim Orth of the University of Texas Southwestern Medical Center and the Howard Hughes Medical Institute has worked to elucidate the activity of bacterial virulence factors on the molecular level, providing insights into how bacteria cause disease and
how eukaryotic host cells signalin response to infection.
The study provides new insights in
how eukaryotic organisms gradually evolved from simpler microbial ancestors.
In this weeks» edition of Nature, researchers from Uppsala University in Sweden, along with collaborators from the USA, Japan, Denmark and New Zealand report the discovery of a new group of Archaea, the Asgard archaea, which reveal important details on
how eukaryotic cells evolved their complexity.
Not exact matches
Zhang, by contrast, showed specifically
how the technique could be used in the more complex (
eukaryotic) cells of rhododendrons, rodents, and humans.
I can discuss with our paleobiologist
how the new fossil record improves our knowledge of
eukaryotic evolution.
An evolutionary relationship between the animal SARM adaptor and bacterial proteins with TIR domains illustrates the possible role that bacterial TIR - containing proteins play in regulating
eukaryotic immune responses and
how this mechanism was possibly adapted by the eukaryotes themselves.
«This is the only system I know about that is amenable for structural work on
how the cellular signal comes down to the chromatin and DNA and that can provide an answer about
how a signal activates a
eukaryotic gene,» Panne says.
My research is framed within the Wellcome Trust consortium on the archaeal origins of
eukaryotic cell organization (http://evocyt.com/), which includes a diverse group of researchers studying the evolution of
eukaryotic machinery from different points of view — e.g.
how do specific cellular systems work in different lineages, and
how did that affect the origin of the
eukaryotic cell plan?