Sentences with phrase «how gene»

Using single - molecule imaging, super-resolution microscopy and various biophysical and molecular approaches she will explore how gene expression in living cells works.»

The overarching goal of his research is to utilize high - throughput genomic data sets, mostly based on DNA sequencing, in order to build models that explain how gene expression is regulated.

Dr. Saptarsi Haldar's research focuses on how cells in the cardiovascular system control gene expression and how these gene control mechanisms go awry during disease.

This allowed the researchers to see exactly how gene activation occurred across the entire human genome.

In addition, we also measured how gene in DNA gain and loss hotspots associate with gene regulatory blocks (GRBs), genomic regions preserved between mammals and birds that are enriched for highly conserved elements [72].

Although this field is still relatively young, evidence for clinical efficacy has been observed and continued progress seems assured, as clinical trials continue to yield insights into how gene therapy can be applied and improvements are made in gene therapy tools.

«The microenvironment has tremendous impact on how the gene is expressed, what type of gene will be expressed.

The next step is to do functional studies to see how these gene variants actually regulate oxygen levels.

Professor Thrasher says: «This is a very powerful example of how gene therapy can offer highly effective treatment for patients with complex and serious genetic disease.

Laboratory and field research is needed to refine gene drive mechanisms and better understand how gene drives work, from the molecular level through species and ecosystem levels.

Although an early study, the results offer a new understanding of TRPA1's role in cold exposure and provide impetus for further research into how this gene could be targeted to enhance the body's protective response to cold.

Throughout the experiment, the researchers kept track of how the gene changed and determined the mutations underlying the evolution of new strains.

Liu said he hopes to continue working with colleagues and participants in China to further investigate how gene and environmental interaction may affect health outcomes across generations.

«We don't even know how gene expression changes on a day - to - day basis!»

Mutations in dozens of genes raise the risk of the disease by small but significant amounts, and researchers are painstakingly uncovering how each gene might contribute.

It remains therefore a mystery how the gene is exactly determined.

We predicted a link between gene expression evolution across species and the degree of sexual selection, but this is the first statistical evidence for it and shows how powerful sexual selection can be in leading to major changes in how a gene is expressed.»

«This solves a long - running mystery of how a gene mutation damages the neurons that carry information from the spinal cord to our muscles, resulting in a range of sensory and movement problems,» says Samuel Pfaff, a neuroscience professor at the Salk Institute and one of the senior authors on the paper with Xiang - Lei Yang, a professor at TSRI.

Their work with laboratory mice also provides a greater understanding of how this gene impacts Menkes disease as scientists search for a treatment.

«We hope that in the future, by fully understanding how this gene affects signaling in the brain, we may be able to identify drugs to restore the normal signaling balance in neurons and improve cognitive and social function in patients,» says lead author Dr. M. Chiara Manzini.

Clearly, more research is necessary, but this new study adds to the growing and substantial effort to understand how the gene variants that contribute to the development of schizophrenia give rise to the cognitive disability commonly associated with it.

Some of those patients have already seen firsthand how gene editing can correct defects in their cells.

The researchers used the worm's genomic information to study how gene expression changed during regeneration.

Researchers have identified a gene that increases the risk of schizophrenia, and they say they have a plausible theory as to how this gene may cause the devastating mental illness.

In their recent paper, the researchers not only looked at the genetic code, but also studied how gene activity varied between the two populations.

Cell receptors will receive a signal from outside, and when it binds, that information is transmitted through the receptor to other proteins within the cell, [creating] a chain of events to change how the gene works in the cell.

To analyze these data, the team developed custom computer software to reconstruct how gene activity changes as motor neurons form.

«Ultimately, this sheds new light on how this gene actually predisposes to diabetes.»

With funding from foreign backers and the Finnish government, the scientists formed a small company, GeneOS, in Helsinki, where they are working on how the gene and its protein work.

Much more research is needed on how gene drive would work under different environmental conditions or whether the selected genes would spread to other species or change in some way over time.

Willette and Webb say they wanted to take a more holistic approach with this study to better understand how this gene affects the course of the disease and certain outcomes such as motor skills and anxiety.

«We know very little about how gene mutations in tumor cells can change how a tumor might respond or not to certain chemotherapy drugs.

«Unraveling mystery in «histone code» shows how gene activity is inherited.»

The study is the first to look at these different biological markers, as well has how the gene's impact on dopamine production specifically affects Caucasian populations.

The study, published in New Phytologist, shows how a gene found in the common fruit fly, Drosophila melanogaster, can be expressed in Arabidopsis, a member of the cabbage family, to improve TNT removal from contaminated soil.

Led by Matthew P. Anderson, MD, PhD, Director of Neuropathology at BIDMC, the scientists determined how a gene linked to one common form of autism works in a specific population of brain cells to impair sociability.

Now, a new study in mice shows how a gene, called FOXP2, implicated in a language disorder may have changed between humans and chimps to make learning to speak possible — or at least a little easier.

They also collected DNA to study epigenetics — changes in the activity of how a gene is expressed through environmental experiences, rather than alteration of the genetic code itself.

The trees (above) illustrate how the gene works.

Conlon's team is now sequencing P. aeruginosa strains to see how gene sequences vary between strains and how this variance affects the ability of these strains to produce the aforementioned factors Conlon's lab has described.

«Understanding how gene editing works in human embryos will require research in human embryos,» because mouse embryos, for example, have species - specific developmental differences, notes Dana Carroll, a biochemistry professor at the University of Utah who researches CRISPR.

«This is a unique and valuable resource for researchers wishing to begin to understand how gene expression is dynamically regulated in human islet cells,» said Kim.

The CREBRF variant appears to be rare in other populations, but studying how the gene works may help researchers better understand obesity.

The observation could explain how a gene that specifies a particular behavior can adapt to accommodate changes in brain circuitry that happen over evolutionary time.

In collaboration with Yi Xing from UCLA, the team catalogued and analyzed how gene expression patterns in skin cells differed among the Esrp knockouts and found hundreds of significant changes.

All land vertebrates carry a version of the FOXP2 gene, so some of the Oxford researchers then teamed up with colleagues from the Max Planck Institute for Evolutionary Anthropology in Germany to analyze what is unique about the variant in humans and to track how the gene had evolved in our ancestors.

Duke Medicine researchers have shown how gene mutations may cause common forms of cartilage tumors.

While the researchers don't know precisely how the gene influences beak size, the work may help scientists better understand the genetic underpinnings of evolution, she says.

It wasn't immediately apparent how the gene regulated fruit fly activity.

Our understanding of how each gene, each cigarette, and the environment interact and how they contribute to disease is comparable to the state of computing in the 1980s.