Sentences with phrase «how gene activity»

Ronai's unique focus on how gene activity changes in cancer promises to continue establishing new paradigms for how cancers develop and respond to therapy.

In their recent paper, the researchers not only looked at the genetic code, but also studied how gene activity varied between the two populations.

To analyze these data, the team developed custom computer software to reconstruct how gene activity changes as motor neurons form.

«Unraveling mystery in «histone code» shows how gene activity is inherited.»

The discovery came from analysing how gene activity changes through the year using blood samples from more than 16,000 people.

Not exact matches

Epigenetics (literally «above the gene») is a recent scientific development that examines how particular mechanisms can influence whether certain genes are turned off, turned on, or modify a gene's level of activity.

By using this tool to analyze their data the scientists were able to catalogue active alleles in a comprehensive set of mouse tissues, or the mouse «Allelome,» and gain an insight into how this differential gene activity is regulated.

By measuring gene activity in the biopsies, the researchers also uncovered a potential mechanism behind how vitamin D aids skin repair.

In addition, future work is required to understand exactly how rs9349379 regulates the activity of the EDN1 gene despite the large physical distance that separates them.

In the journal Cell on July 27, researchers show how this DNA variant enhances the activity of a gene called endothelin - 1 (EDN1), which is known to promote vasoconstriction and hardening of the arteries.

To get a better view of how this might occur, the researchers looked at gene activity in the anterior pituitary glands of foxes in a breeding program at the Institute of Cytology and Genetics in Novosibirsk, Russia, designed to study the evolutionary processes associated with domestication.

By tracking activity in almost all the genes of a free - living archaeon — which, like a bacterium, is a prokaryote — Bonneau was recently able to piece together how the genes affected one another's expression, enabling him to map the organism's «control circuit» as if it were a machine.

How can defective gene activity, which can ultimately lead to cancer, be avoided?

It wasn't immediately apparent how the gene regulated fruit fly activity.

Igoshin said that when the researchers set out to find how sporulation decisions were timed to the cell cycle, several studies including prior work by team members, provided a significant clue: Under starvation conditions, the activity of the master regulator gene had been shown to spike once per cell cycle.

The oxidation status of STAT3, in turn, determined how efficiently the transcription factor regulates gene activity.

They also collected DNA to study epigenetics — changes in the activity of how a gene is expressed through environmental experiences, rather than alteration of the genetic code itself.

Understanding these redundancies, and how to bypass them, could be important for biomedical researchers wishing to manipulate gene activity to treat human diseases.

It is now widely accepted among weight researchers that a person's particular complement of genes determines what activities make him or her susceptible to weight gain as well as how strong that susceptibility is.

At the core of this cell behavior is how the loss of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.

The finding could reveal much about how cells control gene activity, and also illuminate cancer, multiple sclerosis, and other diseases spurred by faulty gene expression.

«Gene analysis adds layers to understanding how our livers function: Tracking gene expression patterns for 20,000 gene in 1,500 cells revealed a mosaic of activities.&raGene analysis adds layers to understanding how our livers function: Tracking gene expression patterns for 20,000 gene in 1,500 cells revealed a mosaic of activities.&ragene expression patterns for 20,000 gene in 1,500 cells revealed a mosaic of activities.&ragene in 1,500 cells revealed a mosaic of activities.»

This result reflected earlier findings that ILC and T cell subclasses produce similar sets of cytokines, but also revealed differences in how the two cell types control the activities of these key immune response genes.

With a cell - by - cell assessment of gene activity they are monitoring how precursor cells shape and organize themselves into something loosely resembling a functioning liver.

The research team used the latest molecular techniques to assess how the activity of genes change as neurons form.

«In this study we weren't looking at how repressing the gene activity affected the symptoms of the disease and this is obviously a critical question as well.

To find out how DISC1 acts on synapses, the researchers also compared the activity levels of genes in the healthy neurons to those with the variation.

For more than a decade, the husband - and - wife team has been investigating how a large protein complex called SAGA, which helps control gene activity in organisms from yeast to humans, influences developmental processes.

Rao's team used various approaches, including assays of telomerase activity, measurement of cell growth, and gene expression profiling of TSY - 1 treated cells, to determine how it acts.

The findings, published in the Journal of Biological Chemistry, shed light on the activity of these genes and how they produce a natural immune response to the virus.

Perera turned the full beam of her attention on Tycko as he explained how the cord - blood samples showed that the gene's activity varied and that it varied in ways that suggested the differences were not random but environmentally influenced.

Inside our cells, they can trigger processes that change gene activity and that ultimately affect how our cells behave.

Our work illuminates how short chain fatty acids contribute to the regulation of proteins that package the genome and, thus, they affect gene activity.»

To find out how rank affected health, the activity of 9000 genes in the animals» immune cells was measured (Science, doi.org/btr5).

«Our research focuses particularly on the activity of this gene and how it relates to neuroblastoma,» says Professor Marie Arsenian - Henriksson at the Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet.

Varun Warrier added: «We now need to confirm these results using new genetic and brain scan data so as to understand how exactly gene activity and thickness of the cortex are linked in autism.»

The researchers now intend to investigate how the different processes that regulate DNA modifications and gene activity might be linked, and which regions of the genome are initially resistant to reprogramming and why that might be.

In today's issue of Science Translational Medicine, he and his colleagues present a more efficient way of finding such new uses for old drugs: by bringing together data on how diseases and drugs affect the activity of the roughly 30,000 genes in a human cell.

The answer to this daunting biological riddle is central to understanding how the three - dimensional organization of DNA in the nucleus influences our biology, from how our genome orchestrates our cellular activity to how genes are passed from parents to children.

Hoping to develop a treatment that works more broadly across diseases, a Penn Vet team used canine disease models to closely examine how retinal gene activity varied during the progression of three different forms of inherited vision disease.

A long - term goal of our research is to understand how neuronal activity elicits changes in gene expression that are important for learning and memory.

«To then determine how disrupting the gene might play out in the context of disease, we chemically knocked out the activity of SLC16A11 in human liver cells,» explains co-first author Victor Rusu, a former Harvard graduate student at Broad now at Jnana Therapeutics.

In exploring how proteins interact with crucial DNA sequences to regulate gene activity, researchers have shed light on key biological...

This text covers topics ranging from plant genome structure and the key control points in how genes are expressed, to the mechanisms by which proteins are generated and how their activities are controlled and altered by posttranslational modifications.

It will be important, Panne says, to dissect in detail how scaffold proteins, such as the CBP and p300 co-activators, contribute to the rich gene regulatory language, how such chromatin modifiers are targeted to the genome, how their activity is regulated, and how chromatin modifications contribute to the signaling reaction.

Eight HARs showed differences in their enhancer activity when the human mutations were present.4 These differences modify how genes were expressed in the developing limb (HAR2, 2xHAR114), eye (HAR25), and central nervous system (2xHAR142, 2xHAR238, 2xHAR164, 2xHAR170, ANC516 / HARE5).4, 10 Because relatively few time points have been examined, it is likely that an even higher percentage of the tested HARs are active enhancers at some point during embryonic development or in adult tissues, possibly with human - chimp differences.

Within this framework, we study how chloroplast genes and metabolic activities are regulated by the products of nuclear genes, usually acting at the transcriptional or post-transcriptional level.

In her essay, she described how the interactions between genes and the environment affect human health and disease, concluding that these environmental influences on gene activity allow people to protect their own well - being by cultivating healthy habits.

To gain insight into how mammalian gene expression is controlled by rapidly evolving regulatory elements, we jointly analysed promoter and enhancer activity with downstream transcription levels in liver samples from 15 species.

New research from Emory University School of Medicine and Harvard Medical School provides insight into how estrogen changes gene activity in the brain to achieve its protective effects.