Sentences with phrase «how gene drives»

Laboratory and field research is needed to refine gene drive mechanisms and better understand how gene drives work, from the molecular level through species and ecosystem levels.

Researchers still don't know how gene drives will behave in the wild, whether the public will accept them or what regulatory hoops they will have to jump through.

Much more research is needed on how gene drive would work under different environmental conditions or whether the selected genes would spread to other species or change in some way over time.

In their July 2014 paper, Esvelt and his colleagues described how gene drive would work: CRISPR would cut a target gene in a cell or cells, probably an egg or embryo.

Not exact matches

CCG will be «squeezing» more clinically meaningful information out of cancer genomics, to understand at the molecular level how genes and mutations drive cancer and determine response to treatment.

Esvelt says he also attended last month's JASON meeting in San Diego, California, where he outlined how would - be bioterrorists might weaponize gene drives.

But he wanted the convention to call for greater transparency in how the technology is studied in labs and deployed in the field, for instance by creating a mandatory gene - drive registry.

Ecologist Ron Thresher got a sense of how the public might react to gene drives when he described his plan to use genetic engineering to rid the Australian waterways of invasive European carp, a voracious fish that can turn a crystal - clear stream into «a disgusting mudhole.»

That report highlighted the UN Convention on Biodiversity as a potential tool with which to regulate gene drives, including how, when and even whether they are deployed.

The project, which will look at how genes and environment interact to drive disease in kids, is different from its predecessors, says Kenneth Mandl, a physician, biomedical informaticist, and one of the project's leaders at Children's.

The study expands our current understanding of the nature of gamete - killing meiotic drive genes and how they can contribute to infertility, she adds.

In the paper, the researchers illustrate how it could influence proteins that activate the transcription factors that transcribe major bone - related genes to drive bone formation — showing a link between metabolite usage and activation of transcription factors.

Gene drive is so different from other technologies involving genetic modification that it requires a whole new way of thinking about how to evaluate and regulate it, says Jennifer Kuzma, a natural and social scientist at North Carolina State University (NCSU) in Raleigh who helped organize a February workshop there.

In some scenarios, gene drive would cause a population to go extinct, and data are lacking on how the loss of a species would affect its local ecosystem.

But specifically how human variants of such genes shape our brain in development — and how they drove its evolution — have remained largely mysterious.

I was fascinated to read how the double duplication of the SRGAP2 gene, which helps drive development of the brain's neocortex, appears to have propelled our ancestors» development at two distinct times during the past few million years (12 May, p 10).

To really understand the origins of retinoblastoma, we need to look beyond genes to understand how epigenetic changes drive cancer.»

Jiggins and others are now trying to figure out what kinds of genes reside within these islands, and how they drive two populations apart.

Researchers investigating pediatric low - grade gliomas (PLGG), the most common type of brain tumor in children, have discovered key biological differences in how mutated genes combine with other genes to drive this childhood cancer.

«The question we asked is, «How does the gene network drive early development from one cell to two cells, two cells to four cells, and so on?»»

The report recommends that the governing authorities, including research institutions, funders, and regulators, develop and maintain clear policies and mechanisms for how public engagement will factor into research, ecological risk assessments, and public policy decisions about gene drives.

They're continuing to sequence prostate tumors to learn how frequently different mutations occur, as well as studying which of the rearranged genes are actually driving cancer.

THEY may not have known about genes and Darwinism, but our ancestors knew how to drive the evolution of once - wild beasts to serve their own needs.

And that's key at a time when an increasing number of researchers are invested in understanding how genes work, how they affect our health, and how they can drive new treatment options.

Complete genome sequencing is required to identify fitness advantages conferred by genes and how antigenic drift in HA / NA drive mutations throughout the genome.

Our meetings examined the variety of new genetic techniques developed to cure human malaria and Zika virus by eliminating mosquitos — such as Oxitec's sterile males, wolbachia applications, and gene drives — and looked at how they might be applied to protect Hawaiian birds.

The scientists who are developing gene drives know how ethically loaded this technology is, and, to their credit, they are trying to put the issue out there for public discussion.

Not content to provide just the missing evidence for a 60 - year - old puzzle, Wilhelm and his colleagues went on to describe what a subset of these genes do in C. elegans and how they might be driving the ageing process.

The resulting datasets of regulatory genomic sequence will provide a valuable resource in determining how non-coding DNA sequence variation may impact an individual's capacity to drive appropriate gene expression.

The model will describe cellular pathways that contribute to tumor formation and explain in detail how the genetic disposition of an individual can activate expression of genes that drive uncontrolled cell growth and lead to cancer.

The new findings also give scientists clues about how gene duplications can drive evolution.

However, the problem is unsolved of how to make these strains useful by driving the genes concerned into wild populations, and especially how to ensure the necessary absolutely unbreakable linkage of these genes to a driving system.»