The new findings also give scientists clues about
how gene duplications can drive evolution.
Not exact matches
And what we did is, in order to figure all this out, sort of trace the path of evolution, we did a whole bunch of sort of, swapping experiments, where we swappedGAL1 for GAL3and we swapped the ancestral protein type of protein in for GAL1or for GAL3, and we even swapped the GAL1and GAL3in for the ancestral protein, in another yeast that didn't have the
duplication take place; and from this whole series of experiments, we really expected to find out pretty much
how the proteins have changed; and the surprise was that most of [the] adaptive change that had taken place wasn't in the protein, it was in
how the two
genes were regulated.
I was fascinated to read
how the double
duplication of the SRGAP2
gene, which helps drive development of the brain's neocortex, appears to have propelled our ancestors» development at two distinct times during the past few million years (12 May, p 10).
Ms. Wojtal: I am looking at
how we can apply the CRISPR / Cas9 system to treat monogenic disorders - specifically editing pathogenic mutations such as
duplications, as well as modulating disease modifier
genes.
It has examined
how new genetic findings (
duplication and deletion or changes in
genes) influence the response to various drugs and whether this information can be used to choose the right drug for the right patient.