Sentences with phrase «how gene expression»

But what we want to do is investigate how gene expression predicts cell type!

We are also examining how gene expression changes caused by chromatin modifier mutations interact with other commonly mutated pathways in urothelial cancers such as RTK - RAS - RAF and PI3K - AKT - MTOR to influence therapeutic response and resistance.

«Vertical integration of gene function» describes how gene expression initiates a series of biochemical, cellular, and physiological changes that ultimately culminate in an observable behavior.

We are also examining how gene expression and mitochondrial function is altered in human cells in the disorder known as Chronic Fatigue Syndrome or Myalgic Encephalomyelitis, in order to develop objective tests for the illness as well to identify causal factors.

Using high - resolution quantitative approaches, her laboratory investigates how gene expression is regulated from both the nuclear and mitochondrial genomes.

RNA - seq technology offers a rapid and scalable approach to characterize how gene expression changes in response to experimental manipulations, and is applicable across a wide range of taxa.

Nick Owens, a post doc in Mike Gilchrist's lab, who developed the computational analysis, said: «This study improves our ability to understand the way gene expression changes with time, and from this we gain insight into the logic of how gene expression is regulated.

«I think we've filled in a major gap in the understanding of how gene expression is linked to the local organization of chromosomes,» says Hnisz.

Erica says, «They are incredibly useful for research - you can get them drunk to understand how gene expression is affected by alcohol.»

Using single - molecule imaging, super-resolution microscopy and various biophysical and molecular approaches she will explore how gene expression in living cells works.»

The overarching goal of his research is to utilize high - throughput genomic data sets, mostly based on DNA sequencing, in order to build models that explain how gene expression is regulated.

«We don't even know how gene expression changes on a day - to - day basis!»

The researchers used the worm's genomic information to study how gene expression changed during regeneration.

«This is a unique and valuable resource for researchers wishing to begin to understand how gene expression is dynamically regulated in human islet cells,» said Kim.

In collaboration with Yi Xing from UCLA, the team catalogued and analyzed how gene expression patterns in skin cells differed among the Esrp knockouts and found hundreds of significant changes.

Not exact matches

The evidence for epigenetic effects on emotion regulation is quite solid: Early caregiving experiences can affect the expression of the genes that regulate a baby's stress and they can shape how the endocrine system will mobilize to stress.

Entitled Social science and epigenetics: opportunities and challenges, the symposium will seek to examine how multidisciplinary research into epigenetics — the science of the lasting marks that modify the expression of the genes encoded in our DNA — might help provide answers to societal concerns including why deprivation has such a marked impact on child development and on health outcomes.

Specifically, the study reveals a mechanism that helps explain how dividing cells pass patterns of epigenetic information called methyl tags to their daughter cells, a crucial part of regulating gene expression across cell generations.

In his second semester, he started doing research in three different labs, including that of Carolyn Decker, a molecular biologist who was investigating how the cell controls gene expression through the destruction of messenger RNA.

A team of scientists led by the University of Birmingham has shown how a common mRNA modification, N6 - methyladenosine (m6A), regulates gene expression to determine the sex of fruit flies.

«It was a little eerie and a little scary to see how something as subtle as a nutritional change in the pregnant mother rat could have such a dramatic impact on the gene expression of the baby,» Jirtle says.

For example, researchers can measure the expression of genes in insect eggs in a corpse to pinpoint exactly how old they are.

By tracking activity in almost all the genes of a free - living archaeon — which, like a bacterium, is a prokaryote — Bonneau was recently able to piece together how the genes affected one another's expression, enabling him to map the organism's «control circuit» as if it were a machine.

EPFL biologists and geneticists have uncovered how the circadian clock orchestrates the 24 - hour cycle of gene expression by regulating the structure of chromatin, the tightly wound DNA - protein complex of the cell.

In a new study published in Physiological Genomics, a team of U.S. researchers tracked in detail how this extreme makeover is controlled by changes in gene expression.

Nadeau wanted to unravel how exposure to it affected methylation and gene expression.

However, very little is known about how the circadian clock regulates this critical part of gene expression to organize the day - night rhythm of protein expression, and if the formation of this looping changes over the day.

Finally, the team identified a network of genes in these regions that exhibit changes in expression when the normal boost from serotonin is lacking, and these changes depended on how long the drug was given.

According to the researchers, this is the first study to link the extreme and rapid eating - induced changes of the Burmese python's intestines directly to changes in gene expression, and also the first to show how quickly gene expression changed.

«This could mean that the reversal or suppression of pathological gene expression by beta blockers is somehow protective against heart failure, but it's something we would need to look into further to understand how individual genes function in the heart.»

«We used the Allen Human Brain Atlas data to quantify how consistent the patterns of expression for various genes are across human brains, and to determine the importance of the most consistent and reproducible genes for brain function.»

This study could help us understand how changing messenger molecule tails could control gene expression in the context of regeneration.

«But the question had remained: How long can you get the gene expression to last?»

«This helps answer a longstanding and important question of how expression of SPI1 and SPI2 genes are synchronised which can result in a potentially fatal infection.»

But in the 1 September issue of the Journal of Clinical Investigation, cardiologist Michael Parmacek and his colleagues at the University of Chicago describe how they deleted two genes from the common cold virus to make it unable to cause any sniffling or fever, then replaced them with a marker gene that turns out an easily detected protein and the SM22 promoter, which turns on expression of genes in smooth muscle cells that surround arteries.

Research into the drivers of genetic diversity has largely focused on gene expression, which controls how much of a given protein will be made, when, and in what tissue.

Others have tracked the first few hours of the embryonic development of sea urchins and other organisms with the goal of seeing how various transcription factors alter gene expression over time.

York University researchers have learned how living beings can keep gene expression in check — which might partly explain the uncontrolled gene expression found in many cancers.

Figuring out how all these elements work together to choreograph gene expression is one of the central challenges facing biologists.

The researchers investigated 16 groups of female and male mice offspring exposed to maternal diet - induced obesity and male hormone excess and studied how these environmental factors affected the mice's behaviour as well as gene expression in the brain.

The research draws from previous findings by molecular biology and genetics professor and study co-author Mariana Wolfner on how Drosophila females» gene expression, behavior and physiology are changed by mating.

This is how he came to develop green fluorescent protein as a reporter for gene expression, for which he was coawarded a 2008 Chemistry Nobel Prize.

Dr Nasr said the ultimate goal of this research was to understand how these antiviral genes are induced and thus coming up with strategies to boost their expression so that the virus replication is not just slowed but completely stopped.

«We want to dig into this further and figure out how these ions impact bacterial gene expression, but that work is still underway.»

It also remains unclear how knocking down expression of certain genes in zygotes via sperm miRNA leads to altered stress response in adult animals and altered gene expression in the brain.

«Mysterious» non-protein-coding RNAs play important roles in gene expression: Study describes how enhancer RNAs are key to gene expression, possibly cancer mutations.»

The finding could reveal much about how cells control gene activity, and also illuminate cancer, multiple sclerosis, and other diseases spurred by faulty gene expression.

While these are important for boosting gene expression, how they achieve this has been completely unknown.

It plays an important role in how cells sense their neighbors and, by controlling gene expression, determines which cells should develop into different types and how much they should grow - like a master controller.»

The Plant Signaling investigation and Biological Research in Canisters (BRIC) 17 - 1 both study how the plants» gene expressions change in microgravity.