Sentences with phrase «how gene pathways»

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By studying these relationships, the researchers have discovered a new pathway to identify how genes influence disease, according to Boerwinkle.

This analysis produced networks that mapped out how alpha - synuclein is related to other Parkinson's genes through well - defined molecular pathways.

They identified previously unknown recurrent loss - of - function mutations that target genes regulating epigenetic pathways — ones that act on how tightly or loosely chromosomes are wound and thus accessible for genes to be expressed.

The daf - 2 gene is also part of a signaling pathway that influences how well cells age and cope with stress.

Still unclear is how the methuselah gene mutation makes flies more stress - resistant, but the amino acid sequence of the protein it makes may be part of a signaling pathway that controls how well cells resist or repair these stresses.

«Although it is unknown how the genes regulate blood pressure,» Zhu added, «our findings contribute to better understanding of blood pressure pathways that can lead to future development of drug target for hypertension and may guide therapy for clinical care.»

The paper demonstrates how BinoX can be used to find many biologically meaningful pathway annotations for gene sets from cancer and other diseases, which are not found by other methods.

He identified some genes in the pathway and studied how it was regulated, comparing it to bacteria and yeast.

These efforts produced a wealth of information about how different genes, and their associated pathways, modulate aging in yeast.

Also, because it is involved in such a critical step in the synthesis pathway, the regulation of the DSYB gene by environmental conditions is of great significance in determining how much DMSP is ultimately produced.»

We still don't know enough about how these molecules influence specific genes, entire gene families, or biochemical reaction pathways.

Case studies described in the article show how microRNAs may affect voluntary alcohol consumption in mice, candidate genes within signaling pathways associated with chronic obstructive pulmonary disease, and the microRNA: gene interactions that influence bladder cancer.

Increasingly, autism researchers are predicting that personalized, more effective treatments will come from understanding these common brain pathways — and how different gene variations alter them.

We are investigating the genes that are the target of this pathway, how it influences the cells of growing worms, the size differences between the sexes (hermaphrodite worms are larger than males), and the way in which it mediates signals from the environment.

Dr. Srivastava's laboratory revealed how cardiac chamber - specific gene networks are established at the transcriptional level and are integrated with signaling pathways.

To gain insight into how genes and pathways were perturbed at the molecular level with loss of bsl1 function, we used RNA - seq to profile transcriptional differences in bsl1 - 1 inflorescence primordia compared with wild - type controls.

How developmental signaling pathways interact with chromatin to establish and maintain lineage - specific gene expression programs remains unclear.

Her research focuses on understanding how signaling pathways control gene expression, using T cells and other cells of the immune system as models.

This line of research will reveal how developmental signaling pathways interact with chromatin to establish specific gene expression programs.

The model will describe cellular pathways that contribute to tumor formation and explain in detail how the genetic disposition of an individual can activate expression of genes that drive uncontrolled cell growth and lead to cancer.

• In nutrigenomics, the basic goal is to discover how diet affects metabolic pathways in the body and how this regulation may be disturbed in diet - related disease — i.e., humans with a certain mutated gene absorb higher levels of fat from the intestine, leading to elevated cholesterol and possible atherosclerosis.

In a paper published in the May 13 issue of Science, authors Christian Petersen and Peter Reddien describe how the gene notum acts at head - facing (anterior) wounds as a dimmer switch to dampen the Wnt pathway and promote head regeneration.

We are also examining how gene expression changes caused by chromatin modifier mutations interact with other commonly mutated pathways in urothelial cancers such as RTK - RAS - RAF and PI3K - AKT - MTOR to influence therapeutic response and resistance.

This gene, which the companies believe is involved in regulating how the body stores and uses energy, implicates a novel pathway in human obesity.

Learn which genetic pathways may be leading to fatigue and how to target these genes to boost daily energy levels.

This provides you with another layer — which is how are the genes that are programming those enzymes support those pathways — and it can provide you with an awful lot of information.

Uh — I don't exactly how it's stimulating it, uh — but uh — but you know, when you do — you know, gene arrays and things like that, uh — you know, working analysis, it seems to be uh — uh — you know, stimulating those two pathways uh — for — for the positive.