He and his colleagues are now investigating
how gene profiles are altered and whether these techniques could ease symptoms in people with high blood pressure, inflammatory bowel disease and multiple myeloma, a type of bone marrow cancer.
Not exact matches
Even before the company's novel
gene -
profiling tool was market - ready, even before they knew
how to outflank a long - established competitor (Affymetrix), Stuelpnagel was looking far into the future.
To illustrate
how it works in practice, Koenig offers the example of a professional hockey player whose
profile shows that he has
gene variants found in people who respond rapidly to lactic - acid threshold training.
Based on
how the
genes fit within the original, mapped
profile, they can predict with a high accuracy if a particular patient will develop metastatic tumors.
Pharmacogenomics — the study of
how genes affect responses to drugs — is becoming more important in drug - development research and clinical trials, with a view toward decreasing side effects and increasing the efficiency and efficacy of drugs in patients with the right genetic
profiles.
Howard Hughes Medical Institute (HHMI) scientists have
profiled key features of the genetic material inside three types of brain cells and found vast differences in the patterns of chemical modifications that affect
how the
genes in each type of neuron are regulated.
Rao's team used various approaches, including assays of telomerase activity, measurement of cell growth, and
gene expression
profiling of TSY - 1 treated cells, to determine
how it acts.
The assay can be used to create a «molecular
profile» that reveals the presence of a
gene and
how much RNA and protein it has expressed all from the same sample — something that now requires three more complicated techniques.
Gene expression
profiling tests, such as Oncotype Dx, analyze the patterns of 21 different
genes within cancer cells to help predict
how likely it is that a women's cancer will recur within 10 years after initial treatment and
how beneficial chemotherapy will be to her.
Modality of access under this proposal: Users will provide either samples or ready - isolated RNA and will decide
how many
genes will be
profiled.
To gain insight into
how genes and pathways were perturbed at the molecular level with loss of bsl1 function, we used RNA - seq to
profile transcriptional differences in bsl1 - 1 inflorescence primordia compared with wild - type controls.
Chinnaiyan's lab, which has extensively analyzed
how genes and proteins in prostate cancer cells reflect these changes, thought that
profiling cells» metabolites would offer an even more «holistic picture of the molecular alterations that occur,» he said.
Dr. Loftus's research has gone on to detail
how SOX10 and its downstream target
gene MITF coordinately regulate
gene expression
profiles associated with melanocyte differentiation.
Concurrently, the research group is examining
how the epigenetic
profile of different candidate
genes predicts, and perhaps changes, in response to recovery from PTSD (and negative self - cognitions) along with its neural correlates.
High - throughput ChIP - Seq: One of the major questions for researchers interested in understanding chromatin dynamics is to investigate
how protein - DNA interactions alter Epigenetic
profiles and subsequent
gene expression.
Many online dating sites have personality
profiling, there is
gene testing, and yet we are still so confused about
how to mate successfully.?