Sentences with phrase «how gene regulation»

SAN FRANCISCO, CA — A scientist at the Gladstone Institutes has discovered how gene regulation can make hearts beat out of sync, offering new hope for the millions who suffer from a potentially fatal heart condition.In a paper being published this week in the online Early Edition of the Proceedings

That is how gene regulation works during transcription.

Not exact matches

The evidence for epigenetic effects on emotion regulation is quite solid: Early caregiving experiences can affect the expression of the genes that regulate a baby's stress and they can shape how the endocrine system will mobilize to stress.

But with smaller parties standing to gain political influence, battles over issues such as the regulation of gene - edited organisms and how to cut greenhouse - gas emissions could grow fiercer.

The newly unmasked genes play a role in three distinctively different bodily functions, including systems that control inflammation and cholesterol and the regulation of how brain cells clean up toxic proteins.

«Although we know that ZMYND11 controls RNA polymerase II travel ratio in the gene body, we still don't know how this protein, which does not physically interact with polymerase II, actually achieves this regulation,» Shi said.

«He was writing in a time before the molecular revolution, before we had much idea of how genes react with one another and the actual molecular basis of changes in genes and their regulation.»

The «methylome» — a picture of the genome regulation taking place in the truffle, is published in the open access journal Genome Biology and illustrates how the truffle deals with its complex genome's repeating elements and «jumping genes».

Together, we related how biophysical and biochemical properties affected by the SRY mutation relate to the regulation of a gene - regulatory network in a biological system.»

An international consortium of researchers in the Genotype - Tissue Expression (GTEx) Consortium published findings about how genetic variation effects gene regulation in 44 human tissue types.

While the study represents a strong start for understanding how eQTLs affect gene regulation and expression, Engelhardt pointed out that she and her colleagues still do not have enough samples to understand trans - eQTLs as deeply as they would like.

Building on years of mouse and gene regulation studies, they have developed a resource that can help scientists better understand how similarities and differences between mice and humans are written in their genomes.

«How good bacteria control your genes: Chemical signals from gut bacteria influence gene regulation in the gut lining.»

Our work illuminates how short chain fatty acids contribute to the regulation of proteins that package the genome and, thus, they affect gene activity.»

Also, because it is involved in such a critical step in the synthesis pathway, the regulation of the DSYB gene by environmental conditions is of great significance in determining how much DMSP is ultimately produced.»

CNIO researchers have now discovered how the MCRS1 protein — a protein associated with gene regulation and cell death processes — is capable of activating mTOR, and thus, stimulate cell proliferation.

The regulation of the CAMP gene by vitamin D was discovered by Gombart, and researchers are still learning more about how it and other compounds affect immune function.

In addition to reevaluating how histones control gene activation, the study also reports a new mechanism of PARP1 regulation.

«Using this approach, we will eventually be able to do the same thing you would do in English class — pick up a book of haiku or Shakespeare and understand that «this is a love poem,» or «this is an elegy,» because we'll understand how the words — the DNA elements — are used in different contexts to convey different meanings on the regulation of genes,» Arnosti said.

«Regarding the other histones, which are major proteins in the regulation of gene expression, we know which enzymes modify them, their functions, and how they are regulated... But for some reason, the functions of histone 1 have not been addressed,» he adds.

Scientists have discovered many points of regulation in the process of using a specific DNA template to make a protein, known as gene expression, that allow the cell to control how much of a certain protein is made at a certain time.

Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the regulation of gene expression and modulation of the host immune response during ¿ - herpesviral infection.

Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the regulation of gene expression and modulation of the host immune response during gammaherpesvirus infection.

Professor Segal's research has two major directions 1) Gene regulation — using quantitative and computational models to understand how DNA sequence variation among human individuals generates phenotypic diversity 2) Microbiome and Nutrition — understanding how the microbial composition of individuals affect their physiology and health.

Sex - specific regulation and tissue - specific gene expression resolve how sex differences evolve from a shared genome

«We looked at regulations of genes, rather than genes themselves, and whether the gene is expressed in certain tissues or how much the gene is expressed there.

Finally, Yingjie Guan, assistant professor (research) of orthopaedics at Brown and Lifespan, at the COBRE for Skeletal Health and Repair, talked about her detailed work on how mechanical regulation of gene expression, for instance by the micro RNA miR - 365, affects cartilage and bone health.

Now that scientists understand how these genes control the heart, they can begin to piece together how heart disease disrupts this regulation.

Throughout his postdoctoral years, at Memorial Sloane - Kettering Cancer Center, and into his tenure at the University of Michigan, Dr. Al - Hashimi remained steadfast in his determination to solve the problem of how to visualize atomic motion, «to obtain a deeper understanding of gene regulation and to build new technologies for drug discovery and biotechnology.»

The Sarma laboratory is interested in the mechanisms of epigenetic gene regulation, or how the dynamic modifications of the architecture of chromatin, the complex of DNA and proteins within the nucleus of our cells, impacts gene expression and cellular function.

That 1975 paper documented the 99 - percent similarity of genes from humans and chimps and suggested that altered gene regulation, rather than changes in coding, might explain how so few genetic changes could produce the wide anatomic and behavioral differences between the two.

• In nutrigenomics, the basic goal is to discover how diet affects metabolic pathways in the body and how this regulation may be disturbed in diet - related disease — i.e., humans with a certain mutated gene absorb higher levels of fat from the intestine, leading to elevated cholesterol and possible atherosclerosis.

These findings provide new insights into how chromatin regulation modulates stochastic gene expression and transcriptional bursting, with implications for regulation of pluripotency and development.Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription.

Bacterial gene regulation has so far been investigated largely using exposure to artificial environmental conditions or to in vitro cultured cells, and little information is available on how S. enterica adapts in vivo to sustain cell division and survival.

Lue, whose essay described the regulation of alternative splicing and how defects in this process can cause disease, and Mueller, whose essay described examples of alternatively spliced proteins coded by the same gene with different functions that act in different cells, will each receive a $ 400 prize, and their science teachers, Dr. Martina Davies and Mrs. Jessica Graham respectively, will each receive a $ 400 grant for genetics materials.

Throughout the 2000s, Wistar scientists made seminal discoveries in the field of epigenetics and RNA transcription, contributing new knowledge on the role of histone modifications in gene regulation and DNA repair and how different RNA species, including microRNAs (miRNA) and long noncoding RNAs (lncRNA), are generated and how they regulate gene transcription.

How does regulation of gene expression determine inner ear function on a genetic and epigenetic level?

The focus of the Mar lab is to understand how variability in gene expression contributes to the regulation of cellular phenotypes.

To know more about how genes are expressed and how changes and down - regulation in its expression affect its translation, watch this video.

Here's what you get during those minutes, according to new reports: an instant endorphin surge and drop in blood pressure, regulation of hunger hormones that may help you keep weight off, and key vitamin D synthesis that alters the expression of 291 genes responsible for everything from controlling how quickly your bones age to how fast you bounce back from tough workouts to how fertile you are.

How gene - environment interactions can shape the development of socioemotional regulation in rhesus monkeys

It seems how you cope with stressful experiences is not only influenced by your prior experiences, but also your genes, coping responses and brain regulation.

How you cope with stress is influenced by your earlier experiences, your genes and brain regulation