Sentences with phrase «how hematopoietic»

One important line of our work has revealed mechanisms how hematopoietic stem cells can generate more myeloid cells to protect transplant recipients from lethal infections.

The researchers focused on how hematopoietic stem cells developed into one of two types of white blood cells: macrophages or neutrophils.

Basic research has centered on identifying and characterizing hematopoietic stem cells, however, it is still not clear how hematopoietic stem cells actually work, and how they are regulated because of the complexity of the bone marrow microenvironment.

Not exact matches

Meanwhile, recent human studies indicate that aging is associated with an increase in somatic mutations in the hematopoietic system, which gives rise to blood cells; these mutations provide a competitive growth advantage to the mutant hematopoietic cells, allowing for their clonal expansion — a process that has been shown to be associated with a greater incidence of atherosclerosis, though specifically how remains unclear.

Hematopoietic stem cells under the microscope: New methods are helping the Helmholtz scientists to predict how they will develop.

In the context of the current study, TRAF6's regulation of RNA isoform expression is important to the function of hematopoietic cells and reveals another dimension to how cells respond to infection, Starczynkowski said.

Finally, I will show how we have combined our results to generate a model of hematopoietic differentiation where specific transcription factors control lineage regulatory regions; our model predicts many already known lineage - controlling factors as well as finds new potential regulators of hematopoietic differentiation such as ATF3 in monocytes and Tcf7l2 and Runx2 in NK cells.

A major scientific puzzle, said Singh, has been how and why immature hematopoietic stem cells initially express genes that are characteristic of more than one cell lineage.

In her project, Sipkins will investigate molecular characteristics of tissue microenvironments, or «niches,» within the bone marrow and how normal, healthy hematopoietic stem cells, which give rise to the many kinds of blood cells, compete with malignant cells to occupy these coveted niches.

For example, we have no information about how these newly - generated HPCs will compete with autologous bone marrow cells for hematopoietic niches in the recipient mice.

Dr. Gazit is focusing on how to develop targeted treatment of cancer cells using hematopoietic stem cells — stem cells used in cancer treatment because of their ability to divide and form new and different kinds of blood cells.

Utilizing sophisticated genetically engineered mouse models, we will study how these conserved longevity pathways regulate the homeostasis and aging of adult stem cells, including hematopoietic stem cells, the adult stem cells that sustain all blood lineages throughout life.