A ONE - OFF treatment for diabetes is a step closer thanks to a better understanding of
how human liver cells can be transformed into something like the beta cells that produce insulin in a healthy pancreas.
Not exact matches
The researchers experimented with inducing oxidative stress in a
human cell line culture with and without VCOP (virgin coconut oil polyphenols) to observe
how VCOP positively promoted catalase, a very important enzyme in protecting the
cell from oxidative damage, and glutathione (GSH), a self - recycling antioxidant produced by the
liver.
In November 2010 Japanese researchers announced online in Analytical Chemistry that they had built a chip that simultaneously tests
how liver, intestine and breast cancer
cells respond to cancer drugs, and in February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the
human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured
cells.
Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as
how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different
human cell types, including normal and cancerous colon, lung and
liver cells, as well as brain, skin, blood and embryonic stem
cells.
There were also slight variations between
how Zika establishes itself in
human liver cells versus neural stem
cells, where it is more physiologically relevant.
Using
cells from mice and
human livers, Toronto General Hospital Research Institute researchers demonstrated for the first time
how under specific conditions, such as obesity,
liver CD8 + T
cells, white blood
cells which play an important role in the control of viral infections, become highly activated and inflammatory, reprogramming themselves into disease - driving
cells.
Next steps include He's collaboration with Piedmont Atlanta Hospital to retrieve T
cells,
liver cancer
cells and healthy tissue normally removed from patients during surgery, put the mouse receptor genes on these T
cells and monitor in a dish both
how those
cells now fight the tumor and react to healthy
human tissue.
«To then determine
how disrupting the gene might play out in the context of disease, we chemically knocked out the activity of SLC16A11 in
human liver cells,» explains co-first author Victor Rusu, a former Harvard graduate student at Broad now at Jnana Therapeutics.