Gage and Ghosh discuss
how human skin cells induced to return to an immature state («induced pluripotent stem cells» or IPS cells) are revolutionizing our understanding and treatment of mental and neurodegenerative disorders, such as Parkinson's disease, as well as leading to new models of drug development for all diseases.
Gladstone scientists study
how human skin cells can be reprogrammed into induced pluripotent stem (iPS) cells, and they are working to refine the production of these cells.
Not exact matches
In a rare appearance Dr. Chandan Sen, Director, OSU Center for Regenerative Medicine &
Cell - Based Therapies will explain
how this breakthrough came about and
how the technology is leading to other medical discoveries and
how the principle can be used to generate any tissue out of
skin or fat which is abundant in
human body.
Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as
how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different
human cell types, including normal and cancerous colon, lung and liver
cells, as well as brain,
skin, blood and embryonic stem
cells.
To decipher
how cells perform this recognition task, Tsao and postdoc Steven Le Chang generated 2,000
human mug shots with variations in 50 features, including facial roundness, distance between the eyes, and
skin tone and texture.
How did you feel when you realised you had made
human embryonic - like
cells from
skin cells?
Similarly, the three research teams that last week reported turning mouse
skin cells into embryolike
cells say they will have to study embryonic
cells to learn
how to reprogram
human cells in the same way and to understand their potential.
In their paper, publishing today in Biofabrication, the team show
how they utilise 3D bioprinting to control the distribution of melanin - producing
skin cells (melanocytes) on a biomimetic tissue substrate, to produce
human - like
skin pigmentation.
Dr. Yamanaka's discovery —
how to transform ordinary adult
skin cells into stem
cells that, like embryonic stem
cells, can develop into any
cell in the
human body.
A decade later, scientists figured out
how to generate another type of all - purpose
cell from
human skin, known as induced pluripotent stem
cells, or iPS.
In findings appearing online today in
Cell Stem
Cell, researchers in the laboratory of Gladstone Investigator Yadong Huang, MD, PhD, describe
how they transferred a single gene called Sox2 into both mouse and
human skin cells.
We are improving
how we reprogram
human skin cells into heart
cells, and are investigating the most rapidly evolving areas of the
human genome to better understand
human disease and evolution.
Shinya Yamanaka MD, PhD, a senior investigator at the Gladstone Institutes has won the 2012 Nobel Prize in Physiology or Medicine for his discovery of
how to transform ordinary adult
skin cells into
cells that, like embryonic stem
cells, are capable of developing into any
cell in the
human body.
Sheng Ding, PhD, has discovered
how to turn
human skin cells into insulin - producing pancreatic
cells.