Sentences with phrase «how huntingtin»

The Steffan laboratory is being funded by the Hereditary Disease Foundation to investigate how the Huntingtin protein interacts with the ubiquitin - tagged trash in order to scaffold it to the lysosome for degradation, and to figure out what kinds of trash may be cleaned up by Huntingtin.

It's not clear exactly how huntingtin helps with the efficient use of iron in the thalamus.

With these details of translation in mind, a team of Huntington's disease researchers, led by Susann Schweiger of The Max Planck Institute for Molecular Genetics in Berlin, decided to study how huntingtin proteins are made from genes of different lengths.

I will discuss how huntingtin regulates several steps of mouse embryonic corticogenesis.

Not exact matches

In Huntington's disease, mice carrying the pathologic genetic variant of the huntingtin gene are being used to understand how this genetic lesion causes degeneration of striatal neurons and to develop novel treatments for the illness.

Hughes said Mooney employed sophisticated computational methods which allowed researchers to comprehensively analyze the functions or so - called «jobs» of the proteins and networks and how they might be impacted by the huntingtin mutation.

«We don't know exactly how the mutant Huntingtin gene causes the disease, so the idea is that targeting the gene expression cuts off the problem at its source — preventing it from ever having the potential to act,» said Dr Isalan.

The team's ongoing study is now looking at how the complete huntingtin protein, which contains parts in addition to the polyglutamine repeats, aggregates.

«A long - standing mystery among researchers was how the buildup of this mutant huntingtin caused cells to degrade and die, but previous technology made it virtually impossible to monitor this process at the cellular level.

In this study, we employed a method called optical pulse - labeling, or OPL, which allowed us to see how the mutant huntingtin ravaged the brain over time — neuron by neuron.»

17:34 - Brivanlou: huntingtin has an influence on the metabolism of embryos - that's how they use energy & do chemical reactions.

Figuring out how the mutant huntingtin protein causes damage is the central problem of Huntington's disease research.

The more we understand about how the normal and extra-long huntingtin proteins are made and work in brain cells, the better equipped we'll be in the search for HD treatments.

In addition, he is also studying the normal huntingtin cellular function in autophagy and how expansion of the poly - Q repeat may impair this function in HD.

She uses a mouse model of Huntington's disease to study how brain cells clear away deposits of mutant huntingtin protein.

But understanding how the brain develops and works, and «knowing the enemy» - the mutant huntingtin protein and its damaging effects - are both crucial if we are going to safely and rapidly develop the treatments we're all working towards.

For example, if we block mutant huntingtin production in cells or animals with «gene silencing» techniques, how can we confirm that this treatment actually does what it's supposed to do in the brains of patients with HD?

But this new information is an important addition to our knowledge of how expanded huntingtin behaves in the brain.

9:17 - The first session is about the huntingtin protein: what is is, what does it do and how does it cause harm?