Sentences with phrase «how inflammatory cells»

Not exact matches

Dr Nachbur said faults in how the NOD2 pathway was controlled could enable the cell to continue to cause inflammation long after the bacterial threat has passed, leading to chronic inflammatory diseases.

To understand the mechanism of how Neu5Gc affects the human immune system, researchers analyzed various cells of the immune system that play a role during an inflammatory reaction.

In their report published in Science Immunology they describe how expression of a specific molecule — complement C5a — is required to cause the immune cells called neutrophils to adhere to joint surfaces and migrate into the joint, a process known to set off the inflammatory cascade.

To understand how and why, Artyomov, first author Monika Bambouskova, PhD, a postdoctoral researcher at Washington University, Alexey Sergushichev, PhD, a researcher at ITMO University in St. Petersburg, Russia, and colleagues treated inflammatory cells from mice and people with dimethyl itaconate, a modified form of itaconate.

«ILCs were discovered less than a decade ago, but the parallels between them and T cells will enable us to more quickly understand how they work and to develop ways to enhance or inhibit their function in treating a variety of immune and inflammatory diseases.»

Professor Bowles, who referred to the research in a panel discussion on «Nature's Marvellous Medicines» at the recent Royal Society Summer Science Exhibition, said: «We were measuring how flavonoids affected the production of inflammatory mediators by cells stimulated by microbial products.

In obesity, a stressed ER in visceral fat cells leads to production of inflammatory molecules called cytokines — but exactly how was unclear.

«By exposing human colonic organoids to inflammatory triggers, we can now learn how the cell lining of the colon and the supporting cells beneath cooperate to respond to inflammation,» Munera said.

Using cells from mice and human livers, Toronto General Hospital Research Institute researchers demonstrated for the first time how under specific conditions, such as obesity, liver CD8 + T cells, white blood cells which play an important role in the control of viral infections, become highly activated and inflammatory, reprogramming themselves into disease - driving cells.

Cardiologists have well - developed ideas for how plaque rupture works *; see the concept of â $ œvulnerable plaque.â $ Cholesterol and inflammatory cells build up in the coronary arteries over several years.

We focus on understanding how cancers cells thrive by exploiting inflammatory processes, corrupting surrounding normal cells and avoiding immune detection.

Topics covered will include how the immune system and commensal microbes interact in the context of health and disease; how dendritic cells respond to infectious or inflammatory stimuli and the roles they play in the induction and polarization of adaptive immune responses against pathogens; how the innate immune pathways regulate inflammation at mucosal barrier tissue sites and how the macrophages are involved in intestinal inflammation.

Thus, given its deep history in understanding how organisms counter infection, LJI is well prepared to lead the charge against inflammatory disease, because often the same cells that rid us of infection are the ones that destroy healthy tissue in inflammatory or autoimmune disease.

how dendritic cells respond to infectious or inflammatory stimuli and the roles they play in the induction and polarization of adaptive immune responses against pathogens.

In addition to providing novel insights into how the deleterious effects of senescent cells are controlled, this pioneering drug screen opens the way for discovering new anti-aging therapeutics aimed at eliminating senescent cells or their inflammatory secretions.

Through a joint UNC School of Medicine - NC State research project shows how to harvest lung stem cells non-invasively and then multiply healthy cells — a potentially powerful therapy against inflammatory lung conditions.

Through a joint UNC School of Medicine - NC State research project shows how to harvest lung stem cells non-invasively and then multiply healthy cells — a potential powerful therapy against inflammatory lung conditions.

Today, several animal studies have been done to learn more about how saponins can inhibit production inflammatory molecules and promote white blood cell activity.

This study demonstrates a snoball effect and shows how the inflammatory response in overweight people actually blocks their ability to burn fat and lose weight by converting white cells to brown cells.