At the molecular level, he is discovering
how mechanical forces signal gene expression to cause cell growth, migration and cell death.
Not exact matches
Donald Ingber, M.D., Ph.D., Founding Director of the Wyss Institute at Harvard University, started investigating this «architecture of life» over thirty - five years ago, and discovered that Nature uses an architectural principle known as «tensegrity» (short for «tensional integrity») to stabilize the shapes of living cells and to determine
how they respond to
mechanical forces.
At the University of Cologne, biophysicists in the lab of Professor Berenike Maier were now able to show
how differential
mechanical forces can lead to cell sorting in biofilms, thereby determining their architecture.
In their publication in the journal eLife, the team headed by the biophysicist Enno Oldewurtel showed
how specific
mechanical forces can be the key to the structure of a biofilm.
Until recently, it was unclear
how the physical pressure of a light touch gets transduced from a
mechanical force to an electrical nerve signal in Merkel discs.
By isolating
mechanical and biological variables one by one in vitro, Mooney and his research team have discovered
how the physical
forces and chemical environment in those dense tissues can drive cells into a dangerously invasive, proliferating mode.
«The sensors could give surgeons real - time feedback on
how much
force they can use during surgery without damaging the tissue,» said Kaiyan Qiu, a University of Minnesota
mechanical engineering postdoctoral researcher and lead author of the paper.
Knowing
how cells exert
force and sense
mechanical feedback in their microenvironment is crucial to understanding
how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion — basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.
How do
mechanical processes like cell adhesion and
force generation influence tissue organization?
\ n \ n «It?s still not clear
how the cells sense shear stress, and researchers are trying to unravel the chain of events between
mechanical force and stem cell production in order to manipulate the process to make blood stem cells for transplant.»
With various colleagues, he created the first
mechanical models of
how cells and tissues form and change during development,
how cells move and
how nano - scale molecular motors inside cells exert
forces on a pico - Newton scale.
In The great all - rounder, Simon Charlesworth discovers what makes the car so appealing to drive / For this month's Auto - biography, Matthew Bell travels to Milan to meet Corrado Lopresto — the well - known collector and view his 150 examples of Italian exotica / In Dealing with a Delage disaster, Douglas Blain tells
how a major
mechanical failure almost took the sole - surviving 1914 Delage Grand Prix car off the road for good, while Philip Guilfoyle explains
how modern technology was used to create a brand new engine block / Doomed by its audacity and now largely forgotten, the Hotchkiss - Grégoire was a technological tour de
force.
Should have said: This is the essence of
how the overall local effect of gravitational
forces acting on an object are reduced to the net effect of tidal
forces in the Newtonian
mechanical view.
The ideal Ex
Forces /
Forces Electrical Maintenance Engineer will have as many of the following in order to strengthen application: Competent reading control circuit / schematic diagrams Knowledge / experience with Proximity switches Knowledge / experience with DC / AC Drives Knowledge / experience with Working with sensors Knowledge / experience with Control systems Knowledge of safety circuits, Invertors,
how relays operate, speed control systems A
mechanical understanding would be advantageous — gearboxes, pumps, pneumatics Knowledge of PLC's advantageous Electrically qualified — Must be able to present these at interview What is in it for you?