Sentences with phrase «how microfluidic devices»
«We're deliberately trying to start a revolution in how microfluidic devices are fabricated,» Nordin said.
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As it can take weeks to grow human cells into intact differentiated and functional tissues within Organ Chips, such as those that mimic the lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity of cells cultured within these microfluidic devices over extended times.
The research «makes one wonder how far it is possible to go in constructing microfluidic «thinking devices,»» says chemist Irving Epstein of Brandeis University in Waltham, Massachusetts.
«WPI brings an outstanding theoretical tool that allows us to understand how microscale objects, such as sperm, interact with their environment; and we are able to design this know - how into real microfluidic devices, clinically validate what we designed, and experimentally improve it into a real - world application.»
With the three - year grant, Vanapalli and his collaborators Boyd Butler in the Department of Biological Sciences and Everardo Cobos at the Texas Tech University Health Sciences Center, will build microfluidic devices that mimic blood flow to study how tumor cells move inside capillaries, how they squeeze through tight spaces, whether they are subject to fragmentation and how they become stuck.
In their article, the teams describe how they used the process to etch patterns of hollow channels like those used to direct the flow of liquids, such as a blood sample, in a microfluidic device, or lab on a chip.
In 2016, Kelley and her team published a study in Nature Nanotechnology that first introduced the microfluidic device and how it could be used to trap and analyze CTCs.