Sentences with phrase «how normal cell»

Our group studies how normal cell behaviour is altered by mutation in the early stages of cancer evolution.

«You have to understand how normal cells work.»

«This calls for a systems level approach, and network analysis techniques, to really understand how normal cells are transformed into cancer cells at the molecular level.»

When studying how normal cells change into cancer cells, dos Santos and other cancer researchers pay close attention to gene expression.

Christofk studies the genes and proteins behind the way cancer cells use sugars to live and grow, which is different from how normal cells do.

Not exact matches

And, perhaps most strikingly, a team at a gaggle of New York research institutions published a paper showing how they'd used hPSCs to cook up — in just days, rather than several months — cortical neurons (critical central nervous system cells) that had normal electrophysiological signaling properties.

Joe W. Ramos, PhD, deputy director of the UH Cancer Center and collaborators focused on investigating how these oncogenes and related signals lead to dysregulation of normal processes within the cell and activate highly mobile and invasive cancer cell behavior.

Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different human cell types, including normal and cancerous colon, lung and liver cells, as well as brain, skin, blood and embryonic stem cells.

In this latest advance reported in PNAS, the Wyss team showed that the human gut - on - a-chip's unique ability to co-culture intestinal cells with living microbes from the normal gut microbiome for an extended period of time, up to two weeks, could allow breakthrough insights into how the microbial communities that flourish inside our GI tracts contribute to human health and disease.

The metabolism of bone cells determines how much sugar they use; if the bone cells consume more sugar than normal, this can lower the glucose level in the blood.

A Biophysical Journal study published September 1 reveals exactly how the venom's toxin — called MP1 (Polybia - MP1)-- selectively kills cancer cells without harming normal cells.

How it hides: In a normal cell, genes encode instructions for surface proteins known as the major histocompatibility complex (MHC).

How it spreads: Unlike normal cancers, where the disease - causing mutation is confined to one organism, devil facial tumor disease (DFTD) cells have evolved the ability to spread from devil to devil.

Most of the time, let - 7 effectively communicated to the gene exactly how much KRAS protein was needed for normal cell turnover.

It is unclear how the entire body is affected because Spector looked only at telomeres, nucleotides on the ends of chromosomes that slowly erode as cells copy themselves during normal aging.

Like Medieval alchemists who searched for an elixir that could turn base metals into gold, biology's modern alchemists have learned how to use oocytes to turn normal skin cells into valuable stem cells, and even whole animals.

These genes are believed to be essential for the normal function of nerve cells, and previous studies have linked these mutations to problems with synaptic function — how neurons communicate with each other.

Pathologists classify tumors by how far their cells deviate from their normal forms, while hematologists identify and count different leukocytes by sight.

Now, thanks to the new mouse model, it will be possible to study how renal tumors are able to develop in an environment with a normal immune system, and how cancer cells manage to evade the immune system's attacks.

One possibility for how that happens, says Hekimi, is that slow cellular metabolism delays the normal buildup of metabolic byproducts, such as reactive compounds known as free radicals, that are toxic to cells.

«We need to know how taste cells grow and work in normal situations before we can harness this knowledge to help people.»

Breast cancer researchers have mapped early genetic alterations in normal - looking cells at various distances from primary tumours to show how changes along the lining of mammary ducts can lead to disease.

At the core of this cell behavior is how the loss of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.

For the first time ever, we could make a really comprehensive comparison of individual normal and tumour cells from the exact same type of tissue, taken at the same time, from the same person, and see how the cancer had developed.»

Ballabio and his colleagues studied the role of the pathway in two normal cellular activities; how cells respond to physical exercise and how they respond to nutrient availability.

«We know that the pathway is important for normal cells to carry their activities as it is involved in regulating metabolism, that is, how cells process nutrients to obtain energy and how cells use energy to grow.

In this webinar we will explore how cancer cells are able to reprogram their metabolic pathways to enable energy production under conditions that are disabling to most normal cells.

The researchers now want to find out exactly how Tregs interact with fat tissue and whether the immune cells accumulate in other organs during normal aging.

He is trying to identify the molecules with which the klotho protein interacts in tissues and to figure out how cells with defective klotho behave differently from normal cells.

Jamieson's team wanted to understand how RNA might change with the aging of normal blood stem cells compared with sAML stem cells.

Endocytosis is not normal in cancer cells but how dysregulated the process is in cancer cells has just been revealed by Sarah Elkin and colleagues in the University of Texas (UT) Southwestern Medical Center lab of Sandra Schmid.

Kipnis and his colleagues wondered how smart mice would be if they had a normal supply of T cells everywhere in their bodies except the meninges, so he injected a compound into mice that prevented T cells from reaching the meninges.

«The potency of these engineered macrophages is relatively clear, but the crucial issue is how to maximize the anti-cancer effects while minimizing side effects, namely the engulfment of normal cells.»

If the egg were indelibly etched with asymmetric information that unequivocably determines development, the argument went, how could two embryonic cells be separated and still produce whole, intact, normal individuals?

For the first time, researchers have been able to grow, in a lab, both normal and primary cancerous prostate cells from a patient, and then implant a million of the cancer cells into a mouse to track how the tumor progresses.

A novel mechanism — similar to how normal tissue stem cells respond to wounding — might explain why bladder cancer stem cells actively contribute to chemo - resistance after multiple cycles of chemotherapy drug treatment.

Although this human Gut Chip recreated the villus epithelium of normal intestine and enabled new insights into how flow and cyclic peristalsis affects intestinal differentiation and function, it could not be used to study processes that relied on normal intestinal cells from individual donors, which, for example, is crucial for studying patient - specific responses for personalized medicine.

C1q also plays a positive role in the brain by clearing out dead cells and helping target harmful materials, so learning how to manipulate its presence to prevent debilitating synapse loss while maintaining its normal functions will require further research.

«This is a significant example of how knowing details of potential mechanisms and the basic science of redox active compounds in cancer versus normal cells can be leveraged clinically in cancer therapy,» says co-senior author Douglas Spitz, who focused on the biochemical studies.

«This difference in metabolism is a key part of how cancer cells have a competitive advantage over normal cells.

Working with Bhaduri, who has a background in statistics and bioinformatics, Pollen and Nowakowski began exploring how specific classes of neurons and stem cells in the developing brain contribute to normal brain growth as well as to neurodevelopmental disease, and have begun to build a comprehensive, open - source atlas of gene expression across the developing brain, which they hope will serve as a resource for other scientists.

«Typical food triggers creation of regulatory T cells: Researchers document how normal diet establishes immune tolerance conditions in the small intestine.»

«This information yields new insights into how sperm stem cells function and develop under normal circumstances,» says the study's lead author Bradley Cairns, PhD, senior director of basic science at HCI and professor and chair of oncological sciences at the U of U. «We have built a very important framework we can now use to help us understand what happens when things go wrong, resulting in issues like infertility and cancer in men.»

«The cancer stem cells actively regrow and respond to the induced damage or apoptosis (cell death) caused by chemotherapy in between the different cycles, similar to how normal tissue stem cells respond to wound - induced damages.»

This shows how a normal process of tissue development produces a cell type that is predisposed to acquire cancer - causing mutations.

Knowing the origin of each cell and which genes control their normal function are the foundations for scientists to decipher the disease process and eventually to find out how to guide the cells to self - repair or even to build up a brand new organ using amended cells from the patients.»

The RNA molecules direct which proteins the cell produces, so the RNA sequences show how tumor cells behave differently to normal cells.

The new study combined two methods: So - called «patch recording» of tiny voltages in single frog brain cells and how the voltages change in response to sounds of different lengths, and the administration of drugs that block neurotransmitters — a way to learn how brain cells respond to sound with and without the normal neurotransmitters.

Dr. David Gilley's laboratory at the Indiana University School of Medicine in Indianapolis and Dr. Connie Eaves» laboratory at the BC Cancer Agency's Terry Fox Laboratory in Vancouver, Canada, collaborated to determine how telomeres are regulated in different types of normal breast cells.

New research provides critical insights into how normal breast precursor cells may be genetically vulnerable to develop into cancer.