An impressive patient account exemplified
how novel therapies developed using animal models improve human health and saves lives.
Not exact matches
«The addition of osteocalcin as a metabolic regulator may one day lead to
novel therapies, but we need to understand much better
how it works and
how it fits into physiology before such
therapies can be attempted in humans,» says endocrinologist Mitch Lazar, director of the Institute for Diabetes, Obesity, and Metabolism at the University of Pennsylvania.
«A better understanding of
how inflammation affects stem cells and other components of tissue will revolutionize our understanding of many diseases, including cancer, and likely lead to
novel therapies,» Naik says.
«Dr. Meyers» research is a perfect example as to
how fundamental laboratory studies are leading to innovative and
novel therapies for breast cancer treatment,» says Dr. Raymond Hohl, director of the Penn State Hershey Cancer Institute.
To build upon the encouraging early discoveries, Helmsley renewed and expanded its Crohn's funding for the Institute in 2013 to begin new work with three major aims: 1) continue studies of individual genes to determine
how genetic differences between Crohn's patients and healthy individuals contribute to the disease; 2) evaluate promising small molecules in disease - relevant studies and prioritize insights from genetics to help develop
novel therapeutics; and 3) begin basic experimentation in animal models with Crohn's disease to provide the data necessary to begin testing new
therapies in humans.
Additionally, this technology could provide a
novel research model by which we transplant cells in vivo to study a disease and its progression from the onset, as well as directly test
how effective new
therapies are.»
The challenge then becomes
how to mine this Big Data to obtain new insights into the causes of diseases, as well as
novel therapies to treat them.
Understanding
how TLR ligation leads to complement induction is of utmost interest, as understanding
how TLR activation manifests as drusen deposits could allow us to develop
novel therapies for the prevention of drusen aggregation.
Dr. Sordella and her team propose a
novel theory of
how some cancers circumvent the killing power of targeted
therapies...
In addition, we will outline
how near - future interventions can be crafted by doing research with
novel technologies during relationship
therapy.