Sentences with phrase «how scaffold proteins»

It will be important, Panne says, to dissect in detail how scaffold proteins, such as the CBP and p300 co-activators, contribute to the rich gene regulatory language, how such chromatin modifiers are targeted to the genome, how their activity is regulated, and how chromatin modifications contribute to the signaling reaction.

Not exact matches

Südhof performed X-ray crystallography and other studies to reveal how a different group of proteins, the complexins, bind to the SNARE scaffold and help to stabilise the structure until synaptotagmin displaces them, calcium - activated synaptotagmin then sparking the fusion of the vesicle with the pre-synaptic membrane.

The Steffan laboratory is being funded by the Hereditary Disease Foundation to investigate how the Huntingtin protein interacts with the ubiquitin - tagged trash in order to scaffold it to the lysosome for degradation, and to figure out what kinds of trash may be cleaned up by Huntingtin.