Sentences with phrase «how signaling pathways»

Researchers will investigate how signaling pathways contribute to hemangiosarcoma growth, and if existing drugs can interrupt the process to reduce tumor growth and chemotherapy resistance.

Her research focuses on understanding how signaling pathways control gene expression, using T cells and other cells of the immune system as models.

Abstract Our team is interested on how signaling pathways control of adult skeletal muscle plasticity.

A fundamental question is how signaling pathways are regulated in time and space to facilitate directional migration of cells.

Understanding how this signaling pathway functions would allow for development of strategies to protect crops against climatic change and to improve photosynthesis so as to generate biofuels and other valuable products.

To figure out how signalling pathways work, molecular biologists carry out and validate experiments, sometimes over many years, to characterise the exact interactions taking place between proteins.

Sartori and his team wanted to find out whether and how the signal pathway and the repair protein CtIP interact with one another.

Not exact matches

I was desperately interested in trying to understand how we could manipulate signaling pathways to improve the treatment of injuries.

«The pathway mainly involves signalling via the brains» immune cells, and thus differs from how today's drugs operate.

Specifically, I am investigating how the cAMP / PKA signaling pathway affects collagen structure and deposition, using a hydrogel - based, three - dimensional culture system to create a model that is more physiologically relevant than one produced by standard two - dimensional tissue culture methods.

In Nature Communications, the scientists conclude that the JAK / STAT signalling pathway, known to be tightly linked to inflammatory processes and tumour growth, determines where, when and how a wing develops in Drosophila.

A signaling pathway is how developing cells get instruction on what types of cell to become, such as a liver cell, a skin cell, a brain cell, etc..

The team's next step is to zoom in on the molecular mechanisms that control how the Wnt signaling pathway interacts with the nail stem cells to influence bone and nail growth.

The daf - 2 gene is also part of a signaling pathway that influences how well cells age and cope with stress.

Still unclear is how the methuselah gene mutation makes flies more stress - resistant, but the amino acid sequence of the protein it makes may be part of a signaling pathway that controls how well cells resist or repair these stresses.

Understanding how this immune system is regulated at the appropriate level of activity gives the researchers more ideas of points in the immune signaling pathway that could targeted to increase the plant's baseline ability to resist disease.

Now that we have discovered how Group A strep bacteria communicate with each other to coordinate the production of this toxin, we can target the signaling pathway for vaccine and antimicrobial development.»

Dr. Nguyen then worked at the Buck Institute for Research on Aging and at Stanford University, where she investigated the signaling pathways underlying neurodegeneration and how the modulation of these pathways can influence the AD phenotype.

This study reveals how lipids control SH2 domain - mediated cellular protein interaction networks and suggests a new strategy for the therapeutic modulation of pY - signaling pathways.

This webinar will focus on how rewiring of signaling pathways in response to drug treatment contributes to resistance and how this knowledge can be leveraged to develop more effective treatment strategies.

«For example, mouse mammary tumors shared a signaling pathway that is found in human lung cancer and controls how cells reproduce and move from one location to another.»

Jasper says TOR can be regulated by a number of stimuli, and researchers are now attempting to better understand how the activity of this signaling pathway is controlled in stem cells.

Scientists at the Wyss Institute at Harvard University set out to solve the mystery of how blood flow keeps the vessels intact and, to their surprise, discovered a completely new cell signaling pathway that is a promising target for drugs to treat a variety of debilitating conditions.

Case studies described in the article show how microRNAs may affect voluntary alcohol consumption in mice, candidate genes within signaling pathways associated with chronic obstructive pulmonary disease, and the microRNA: gene interactions that influence bladder cancer.

One aspect of their work studies how cell signaling pathways, such as those that initiate cell growth or death, are affected by the nanostructures and microstructures of implant materials such as titanium.

Still unclear is how enhanced signaling through the insulin pathway protects against obesity, although the researchers speculate that it might boost energy consumption by liver and muscle cells.

However, her research group has not yet identified how to make stem cells yield entirely dI1 or entirely dI3 cells — perhaps because another signaling pathway is involved, she said.

A multi-institutional international study led by scientists at The University of Texas MD Anderson Cancer Center has revealed new information about how molecules called long non-coding RNAs (lncRNA) interact with HIF - 1, a signaling pathway that is overexpressed in many cancers.

It locks onto and deactivates a protein, Smoothened, that activates the Hedgehog signaling pathway, which orchestrates how embryonic stem cells develop.

But what scientists did not know is how the mutations trigger a molecular signaling pathway that leads to the death of photoreceptor cells.

We therefore believe that a targeted inhibition of this specific signalling pathway, which controls how the cells in the vessel walls are connected, might work better as a cancer therapy than the more general VEGFA inhibition that is used today,» says Lena Claesson - Welsh.

An understanding of how these noise features differentially affect signal encodings along the auditory pathway would require further experiments utilizing a broader set of background noises.

We are particularly interested in how several molecular signalling pathways control the size to which the worm grows (about 1 mm long).

We are investigating the genes that are the target of this pathway, how it influences the cells of growing worms, the size differences between the sexes (hermaphrodite worms are larger than males), and the way in which it mediates signals from the environment.

Major studies how cancer cells hijack specific signaling pathways to spread throughout the body, using drugs and genetic manipulation to probe the inner workings of these out - of - control cells.

To better understand how insulin signaling affects beta - cell growth, the Joslin scientists next studied a pathway involving a protein called FOXM1.

Dr. Srivastava's laboratory revealed how cardiac chamber - specific gene networks are established at the transcriptional level and are integrated with signaling pathways.

While core pathways for BR metabolism and signaling have largely been defined, little is known about the molecular mechanisms regulating BR homeostasis and how these in turn modulate plant development.

Here we show how second messengers relevant to the Gq signaling pathway can be detected in living cells using assays for DAG, PIP2, and Ca2 +.

Her goals are to continue working to understand how the dynamics of p53 and other signaling pathways important in cancer control cell fate decisions.

How developmental signaling pathways interact with chromatin to establish and maintain lineage - specific gene expression programs remains unclear.

A Emory News item on a helpful part of the microbiome focuses on how the same type of bacteria â $ «lactobacilli â $ «activates the same ancient signaling pathway in intestinal cells in both insects and mammals. It continues a line of research from Rheinallt Jones and Andrew Neish on how beneficial bacteria stimulate wound healing by activating ROS (reactive oxygen species).

Learn about the different classes of chemokines, their receptors and how chemokine signaling activates the JAK / Stat, Ras, Erk and Akt pathways.

We are applying an interdisciplinary approach to study the consequences of aberrant activation of the cAMP / CREB / CRTC signal circuit on these adaptive responses and how cooperative signaling with other pathways promotes oncogenic processes in oral, head, and neck cancers.

This line of research will reveal how developmental signaling pathways interact with chromatin to establish specific gene expression programs.

So today we'll discuss insulin signaling and leptin signaling pathways, we'll talk about the molecular basis of insulin resistance and leptin resistance, and then we'll try to talk about at the end how insulin and leptin signaling interacts to regulate appetite, food intake and metabolism.

«Knowing the subcellular location of a given protein is of great importance as it indicates the protein function and leads to a better understanding of how and why proteins interact in networks and signaling pathways.»

And drugmakers want to see how these kinds of structures can inspire new medicines that can direct GPCRs to couple to different signaling pathways, adds Fiona Marshall, chief scientific officer of Heptares Therapeutics, a GPCR - targeted pharmaceutical company.

Our goal is to identify signaling pathways which control or coordinate these different phenotypic transitions and to evaluate how these pathways can be influenced by the cellular environment, altered in pathological contexts or serve as therapeutic targets.

May 11, 2015 Disrupting cancer pathway could enhance new immunotherapies Understanding how to overrule a signaling pathway that can cause treatments to fail in metastatic melanoma patients should help physicians extend the benefits of recently approved immunity - boosting drugs known as checkpoint inhibitors to more patients.