Sentences with phrase «how signaling proteins»

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Within the framework of research projects of the German Center for Diabetes Research (DZD), scientists of the Research Unit Protein Science (PROT) and the Institute of Experimental Genetics (IEG) at Helmholtz Zentrum München (HMGU) have now investigated how drug treatment affects these signal carriers.

A team led by Carnegie's Wolf Frommer has revealed how membrane proteins were networked with each other and with the signaling proteins inside the cell.

Researchers still don't know how this range corresponds to their versatile functions, but being more like a string than like a lump with keyholes means that a protein can make many contacts with other molecules to regulate the network of signals that drives the cell.

But little is known about how ionizing radiation affects the extracellular matrix (ECM), a patchwork of proteins and other biomolecules that surrounds cells and plays a vital role in their shape, movement and signaling functions.

Future research will focus on how this receptor works with ATP, its protein structure, how it reacts to pests and how it may signal growth.

Now, new research from the Salk Institute shows how a protein called p75 is critical for pain signaling, which could one day have implications for treating neurological disorders as well as trauma such as spinal cord injury.

Researchers from UT Southwestern's Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Internal Medicine's Division of Nephrology recently published work in Nature that reveals the molecular structure of the so - called «anti-aging» protein alpha Klotho (a-Klotho) and how it transmits a hormonal signal that controls a variety of biologic processes.

«Scientists determine structure of enzyme linked with key cell - signaling protein: Findings aid understanding of how modifications to cell - signaling protein affect its action in turning genes on and off.»

Still unclear is how the methuselah gene mutation makes flies more stress - resistant, but the amino acid sequence of the protein it makes may be part of a signaling pathway that controls how well cells resist or repair these stresses.

«The computational approach allows us to model, right down to the atomic level, how small changes in protein sequence can have a major impact on signaling,» said MacDermaid, assistant professor of research at Temple's Institute for Computational Molecular Science.

That will require fully characterizing the protein and figuring out how DAZAP1 senses external signals like nutrients or growth factors that regulate its properties.

This study reveals how lipids control SH2 domain - mediated cellular protein interaction networks and suggests a new strategy for the therapeutic modulation of pY - signaling pathways.

«Intracellular signaling depends on these protein modifications — so by doing these analysis, we know not only what's in the cell, but also how the cell organizes and communicates internally.»

By tracking how the levels of the CA125 protein change over time we might have an early signal to detect tumours.

Cell receptors will receive a signal from outside, and when it binds, that information is transmitted through the receptor to other proteins within the cell, [creating] a chain of events to change how the gene works in the cell.

The molecular details of how these viruses self - assemble protective protein containers around their cognate genomes in a specific and efficient manner have been revealed and illustrate multiple contacts between coat proteins and dispersed packaging signals in the viral genome.

To figure out how signalling pathways work, molecular biologists carry out and validate experiments, sometimes over many years, to characterise the exact interactions taking place between proteins.

Although Yersinia's molecular syringe for shooting up macrophages was discovered 4 years ago, scientists couldn't figure out how the bacteria knew what to load into it; the toxins, called Yersinia outer proteins (Yops), had no apparent amino acid signal for secretion.

Sartori and his team wanted to find out whether and how the signal pathway and the repair protein CtIP interact with one another.

During the early years of my PhD studies, I was very fascinated by the exciting discoveries in the field of signal transduction, in particular how receptor tyrosine kinases are activated to transmit their signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.

In a separate study, published in September by the journal eLife, Butler and her colleagues discovered how signals from a family of proteins called bone morphogenetic proteins, or BMPs, influence the development of sensory interneurons in chicken embryos.

It locks onto and deactivates a protein, Smoothened, that activates the Hedgehog signaling pathway, which orchestrates how embryonic stem cells develop.

Researchers have identified a protein that controls how breast cancer cells spread around the body, according to a Cancer Research UK - funded study published in Science Signaling.

For the first time, they have uncovered the structural details of how some proteins interact to turn two different signals into a single integrated output.

Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have discovered how two important proofreader proteins know where to look for errors during DNA replication and how they work together to signal the body's repair mechanism.

Scientists from The Scripps Research Institute Florida campus have uncovered the structural details of how some proteins interact to turn two different signals into a single integrated output.

To better understand how insulin signaling affects beta - cell growth, the Joslin scientists next studied a pathway involving a protein called FOXM1.

When Walter arrived in Blobel's lab as a fresh - faced apprentice, Blobel and his colleagues had limned the outlines of the so - called signal hypothesis, which purported to explain how proteins, which are made in cellular machines called ribosomes, find their pre-destined locations within cells.

Studies are being carried out to determine the functional effects that occur when these receptor - ligands interact; to determine how these proteins induce their activities at the molecular level and transmit signals to T cells; and to determine the significance of these proteins in several disease scenarios such as asthma, scleroderma, and atopic dermatitis.

«Knowing the subcellular location of a given protein is of great importance as it indicates the protein function and leads to a better understanding of how and why proteins interact in networks and signaling pathways.»

It is located on the long arm of chromosome 15 in the LINGO1 gene, which encodes a protein that has been shown to affect how neurons are formed and signal each other.

It will be important, Panne says, to dissect in detail how scaffold proteins, such as the CBP and p300 co-activators, contribute to the rich gene regulatory language, how such chromatin modifiers are targeted to the genome, how their activity is regulated, and how chromatin modifications contribute to the signaling reaction.

Given their close proximity and the tendency of investigators to assign a GWAS hit to the nearest protein - coding gene, I wonder how often a genetic signal from a p - lncRNA is erroneously assigned to the mRNA instead.

Beyond the internal interactions of the protein itself, these designed oligomers can be used to explore basic questions about how the structure of signaling molecules affects the behavior of receptors and cellular response.

The aim of this study is to characterize how neurons from the mediobasal hypothalamus respond to a signal of protein availability: the amino acid l - leucine.

His doctoral thesis revealed how isoprenylation of MIEN1 protein can regulate its translocation to the plasma membrane and activate signaling events leading to increased invasive phenotype (JBC, 2011; Mol Can, 2015).

We still don't know how exactly protein increases satiety, but some studies have suggested that protein has an important beneficial influence on the secretion of CCK (cholecystokinin), the hormone responsible for acting as a satiety signal, and ghrelin, the main hunger hormone in our bodies.

These signals tell the body how to metabolize fats, proteins and carbohydrates, and how to cope with «environmental stress».

In the following the scientist gives his explanation how to reverse it: «These new insights into Western diet - mediated mTORC1 - hyperactivity provide a rational basis for dietary intervention in acne by attenuating mTORC1 signaling by reducing (1) total energy intake, (2) hyperglycemic carbohydrates, (3) insulinotropic dairy proteins and (4) leucine - rich meat and dairy proteins.