Europe came through: Last year, Cory received a European Molecular Biology Organization (EMBO) Installation Grant for his lab in mitochondrial biogenesis, and Gülayşe won a Marie Curie International Reintegration Grant from the European Commission to study
how single genes can yield different protein products in neurons.
MIT neuroscientists have now shed some light on
how a single gene can play a role in more than one disease.
In school, we focus our attention on
how a single gene can influence one trait, like tongue rolling, dimples, and widow's peak.
Not exact matches
After
gene - typing about 3,000 people, Sturm found that
how OCA2 is expressed — and
how much pigment a person has — is strongly linked to three
single nucleotide polymorphisms (SNPs), or
single letter variations, in a DNA sequence near the OCA2
gene.
Molecular geneticists dream of having a similarly comprehensive view of networks that control
genes: For example, they would like to identify rules explaining
how a
single DNA sequence can express different proteins, or varying amounts of protein, in different circumstances (see p. 80).
«What is so remarkable about dati is that females that are mutant for just this
single gene can never decide to accept males, no matter
how hard the males try to impress them» says Joseph Schinaman, a PhD student and first author of the publication.
At the core of this cell behavior is
how the loss of that
single gene changes activation levels of dozens of other
genes, suppressing
genes associated with metastatic disease and increasing activity of
genes linked to normal tissue.
The researchers looked at functional
single nucleotide polymorphisms within the CLOCK
gene that are able to influence
how much protein is transcribed from the
gene.
In this episode, Scientific American news editor Phil Yam discusses
how veterinarians, physicians and multinational food companies need to work together in the global fight against animal - borne infectious diseases; and University of Wisconsin evolutionary biologist Sean Carroll talks about recent research tracking the evolution of yeast
genes with specific functions descended from a
single, duplicated
gene with multiple functions.
At a symposium at The American Society of Human Genetics here last month, they reported zooming in on the
genes expressed in a
single brain cell, as well as panning out to understand
how genes foster connections among far - flung brain regions.
Not only would it be enormously difficult to manipulate so many
genes in a
single person, but scientists would still have to reckon with the even more complicated matter of
how the environment influences those
genes.
The researchers, led by Dr Charles Wondji, used a wide range of methods to narrow down
how the resistance works, finding a
single mutation in the GSTe2
gene, which makes insects break down DDT so it's no longer toxic.
Beyond offering further proof that
single genes can have dramatic influences on longevity, an idea that drew skepticism just a decade ago, the new finding may help scientists explain
how severely reducing calorie intake extends life span in a variety of animals (SN: 11/25/00, p. 341: Low - cal diet may reduce cancer in monkeys).
Using novel technologies developed at HMS, the team looked at
how a
single sensory experience affects
gene expression in the brain by analyzing more than 114,000 individual cells in the mouse visual cortex before and after exposure to light.
How kind you are could be affected by a change in a
single gene.
How important was a
single gene in the evolution of human language?
«Mutations in Shell explain the
single most important economic trait of the oil palm:
how the thickness of its shell correlates to fruit size and oil yield,» explains Dr. Rajinder Singh of the MPOB, first author of the Nature paper describing the Shell
gene.
Thus I was able to ask
how the expression of this
single gene limits the size of the haltere.
Studies of worms and fruit flies show that variations, or polymorphisms, in a
single gene can affect
how long these creatures live.
Using
single - molecule imaging, super-resolution microscopy and various biophysical and molecular approaches she will explore
how gene expression in living cells works.»
«This work reveals
how a
single mutation in a key cardiac
gene can lead to at least two forms of disease.»
The sequential processes of somatic cell reprogramming to create patient - specific hiPS cells, CRISPR / Cas9
gene editing, and
single - cell cloning uniquely enable researchers to study
how a specific genetic modification can influence function.
In findings appearing online today in Cell Stem Cell, researchers in the laboratory of Gladstone Investigator Yadong Huang, MD, PhD, describe
how they transferred a
single gene called Sox2 into both mouse and human skin cells.
Researchers have achieved new insights into
how the global control of all
genes on a
single chromosome can be established and maintained throughout the lifetime of an organism.Their findings about...
Genes aren't single - function, self - contained switches, and we're only just beginning to learn how they interact — both with other genes and with environmental and lifestyle factors — to create living, unique human be
Genes aren't
single - function, self - contained switches, and we're only just beginning to learn
how they interact — both with other
genes and with environmental and lifestyle factors — to create living, unique human be
genes and with environmental and lifestyle factors — to create living, unique human beings.
In DNA, each protein is encoded by a
gene (a specific sequence of DNA nucleotides that specify
how a
single protein is to be made).
This is possible since no information about
single individuals are given out, only
how frequently occurring a certain
gene variant is within the group.»
Feng's group is focusing first on conditions with the strongest human genetic data, such as Huntington's disease, in which a
single gene causes a disorder, and using advanced neuroimaging technology and other tools to understand
how the mutation causes brain circuits to misfire.
The recent Nobel Prize winner explains
how the technology of studying the effects of
single genes has revolutionized the study of mammalian biology of human medicine.
Of course, said David Gunn, one of the researchers on the study, there is no
single youthfulness
gene, and many factors affect
how your looks change with age — including
genes and lifestyle.
I wonder,
how can a woman who takes the time to stay in good shape, and who was born with good
genes be discriminated against in the
singles scene?
But if they have fewer
genes,
how is it possible that a
single species, canis lupus familiaris, could evolve so quickly?