Sentences with phrase «how small molecules»

Jahns fell into medicinal chemistry early in his academic career, after seeing how small molecules could affect biological systems.

Researchers from all over the world are challenged to predict how small molecules, such as pharmaceuticals, bind to GPCRs at the atomic level.

Accurate modeling of how small molecules bind to GPCRs could contribute to development of new pharmaceuticals.

Focusing on antibiotics that have been used to counter infectious disease of humans, Walsh provides an up - to - date analysis of how these small molecules interfere with crucial processes in bacteria.

Well, one of the issues that we have to think about is how small molecules can get across membranes without all the complicated modern biological machinery that controls the transport of molecules across membranes.

But it was not clear how smaller molecules could have found each other and built ribose in rigid ice.

Not exact matches

When you listen to the tapes on how the DNA molecule is stripped apart and how a small ensemble of enzymes goes pirouetting down the spiral staircase in a perfectly orchestrated ballet of replicating agents, it is hard not to think that a cosmic choreographer is responsible for the entire performance.

Our team is currently developing methods that can be used to screen small molecule inhibitors of EDD1 and also looking into how the regulation of TIP60 levels can be translated into therapeutic advances for the treatment of viral - mediated cancers such as cervical cancer.

This is the science of how atoms and molecules react with each other and how larger molecules are constructed from smaller ones.

The acidity of urine — as well as the presence of small molecules related to diet — may influence how well bacteria can grow in the urinary tract, a new study shows.

Traditionally, a highly trained chemist spends years trying to figure out how to make each one before its function can even be explored, a slowdown that hinders development of small - molecule - based medications and technologies.

Coincidentally, co-author Lawrence Shapiro, PhD, at Columbia, was building a crystal structure of cadherin - 11 and is now working with Byers and Brenner to show how the molecule binds to Celebrex and other small molecule drug cadherin - 11 inhibitors.

The molecule, miR - 34a, belongs to a family of small molecules called microRNAs (miRNAs) that serve as brakes to help regulate how much of a protein is made, which in turn, determines how cells respond.

The Wuhan lab will give his group a chance to study how such viruses cause disease, and to develop treatments based on antibodies and small molecules, he says.

«That's very much dependent upon the energy of these orbitals and how well they're able to overlap with the orbitals of the small molecules that are coming to the surface.

The research team has been using NMR — a technique related to the one used in MRI body scanners and capable of visualising molecules at the smallest scales — to examine how small components of herpes virus help it to multiply by binding themselves with other large molecules; this produced images of a monkey herpes virus protein interacting with mouse cellular protein and viral RNA.

And Weinstock notes that if researchers can determine how the parasites trigger the shift in microbe composition, «we may be able to bypass the worms and develop a small molecule drug to get the effect in a safe way.»

Now plant biologists and immunologists at York have joined forces to examine a very closely related family of these small molecules (flavonoids) to establish how tiny changes to their chemical structures affect their bio-activity.

«Now that we have this quantifiable result, that with only 12 building blocks we can make more than 75 percent of polyenes, we are committed to figuring out a global collection of building blocks — how to make them, how to put them together — to create a generalized approach for small - molecule synthesis.»

While its extreme conductivity makes graphene especially suited for small - scale electronics, the authors» primary interest lay in how it accommodated nearly any type of molecule — specifically, ammonia — they placed between it and the ferroelectric layer.

«It's important for us to study materials from asteroids and meteorites, the smaller versions of asteroids that fall to Earth, to test the validity of our models for how molecules in them could have helped give rise to life.

These small RNA molecules must be trimmed from long hairpin - loop structures, raising a question: How do cells know which RNA loops need to be processed this way and which don't?

Three men will share the honor for their work describing how small membrane bubbles loaded with molecules get sorted to the correct part of the cell.

«Our research revealed how small RNA molecules can work with other cell signals called transcription factors to generate specific types of neurons, in this case motor neurons.

Scientists have been working for decades to understand how anthrax toxins get into cells; recently researchers have started exploring the possibility of mimicking this system to deliver small protein molecules as vaccines.

Most surfactants, like soap molecules in bubbles and phospholipids in cellular membranes, have small water - loving (hydrophilic) heads and long fat - loving (hydrophobic) tails that determine how they arrange in space.

«This research very nicely demonstrates how collaboration among scientists with diverse areas of expertise, ranging from genomics to small molecule chemistry, can lead to new insights into plant defensive metabolism,» said BTI Professor Georg Jander, a co-author of the paper.

For example, using sophisticated calculations and supercomputers, he developed accurate methods for calculating how small, light molecules and atoms such as helium and hydrogen would move and react in solids and in solution.

I remember the day I decided to become a geneticist; it was a way of exploring how such complexity and beauty can be packaged into something so small as a DNA molecule.

Not a light read, this tome is bursting with information about monoclonal antibodies, from the history of how these therapies were first developed to new approaches such as conjugate therapy, which combines antibodies with small - molecule drugs.

At the moment, I don't think anyone has much of an idea on how to identify good small molecule candidates with conventional medicinal chemistry methods (though I'm intrigued to hear that you have some thoughts, AH!).

To build upon the encouraging early discoveries, Helmsley renewed and expanded its Crohn's funding for the Institute in 2013 to begin new work with three major aims: 1) continue studies of individual genes to determine how genetic differences between Crohn's patients and healthy individuals contribute to the disease; 2) evaluate promising small molecules in disease - relevant studies and prioritize insights from genetics to help develop novel therapeutics; and 3) begin basic experimentation in animal models with Crohn's disease to provide the data necessary to begin testing new therapies in humans.

Practically speaking, this knowledge of how the toxin recognizes the double receptor could lead to a rational basis for designing small - molecule inhibitors to this recognition step,» he said.

Memory improved in mice injected with a small, drug - like molecule discovered by UC San Francisco researchers studying how cells respond to biological stress.

How binding of a small molecule can increase the performance of a muscle by promoting an increase in myosin motor force was unclear.

Complementary collaborative work between Cytokinetics and the team headed by Anne Houdusse has also uncovered how highly specific small molecules can stop smooth muscle myosin activity.

Americans James E. Rothman and Randy W. Schekman, and Germany's Thomas C. Sudhof, discovered the principles that determine how molecules produced by cells are transported in small sacs called vesicles, which deliver them «to the right place at the right time,» according to the Nobel Committee decision.

Paulaitis says «the novel concepts put forth in this study, of investigating small molecules called microRNAs to see what they can tell us about mitochondria disorders in cells of the retina, hold great promise of providing new insights into how age - related macular degeneration develops, after which new treatments can be designed to save or improve vision.»

The fundamental Physics of how light interacts with small particles suspended in the medium it travels through make the GHE impossible to avoid, where there are molecules with three atoms in the atmosphere and visible light that strikes a visible surface that is not perfectly reflective.

Now the only thing I don't seem to know is the proper division of rates of overall radiation from the bulk atmosphere and how much might actually reverse thermalize back to the GHG gases with most molecules just thermalizing again and a small fraction actually radiating.