Not exact matches
What these
cell fate determinants are and
how they are distributed when a
stem cell divides is another big question.
Researchers have been trying to understand
how this precursor
stem cell decides its
fate.
«This study can further our shared understanding of
how the microenvironment can regulate the differentiation and
fate of a progenitor or
stem cell.»
The results provide more clues about
how cells choose a particular
fate and may guide efforts to use
stem cells to treat certain diseases.
From directing the
fate of
stem cells to determining
how tall we grow, the genes in our body act in complex networks.
«It suggests to us that targeting the pathways used in regulating
cell fate decisions —
how stem cells choose between
cell proliferation and differentiation — could be a more effective way of halting tumours in their tracks and lead to potential new therapies.»
The project will focus on answering the question,
how an embryonic
stem cell computes cues from its environment to elicit a regulated, exact
cell fate choice during a process called «differentiation».
The question of
how cellular behavior is controlled is at the center of
stem cell biology, and understanding the mechanisms of
cell fate regulation is key for treating diseases that occur upon dysregulation, such as cancer or diabetes.
Research in his Laboratory of
Stem Cell Bioengineering (LSCB) is at the interface of stem cell biology and biomolecular engineering to gain fundamental insight into how protein components of niches control the fate of adult stem ce
Stem Cell Bioengineering (LSCB) is at the interface of stem cell biology and biomolecular engineering to gain fundamental insight into how protein components of niches control the fate of adult stem ce
Cell Bioengineering (LSCB) is at the interface of
stem cell biology and biomolecular engineering to gain fundamental insight into how protein components of niches control the fate of adult stem ce
stem cell biology and biomolecular engineering to gain fundamental insight into how protein components of niches control the fate of adult stem ce
cell biology and biomolecular engineering to gain fundamental insight into
how protein components of niches control the
fate of adult
stem ce
stem cells.
This illustrates
how biophysical cues determine
stem cell fate and spatial patterning.