Sentences with phrase «how telomerase»
To understand how telomerase RNA participates in mechanistic aspects of telomere synthesis, we studied a conserved secondary structure adjacent to the template.
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Voice: The 2009 Nobel Prize in Physiology or Medicine goes to Harvard's Jack Szostak, Johns Hopkins's Carol Greider and Elizabeth Blackburn at U.C. San Francisco for their work on how chromosomes are protected by telomeres and the enzyme telomerase.
«Our findings have implications for how to think about the earliest processes that drive cancer and telomerase as a therapeutic target.
«We identified a motif in the protein component of telomerase that controls how the enzyme carries out its activity in vertebrates such as ourselves.»
This model structure of the catalytic portion of telomerase shows how the TFLY motif (green) is positioned at the entry of the pocket that guides the RNA template in the interior cavity of the telomerase ring and were the active site of the enzyme if located for catalysis.
In this webinar, our experts will describe the advances in telomere research as it applies to human health and how deeper characterization of the telomerase maintenance process can uncover targets for therapies.
Rao's team used various approaches, including assays of telomerase activity, measurement of cell growth, and gene expression profiling of TSY - 1 treated cells, to determine how it acts.
In tomorrow's Cell, researchers describe how older mice lacking the enzyme telomerase — which helps protect dividing chromosomes — go prematurely grey and begin to lose their fur.
How does telomerase manage to bypass the protective function of telomeres?
Learning how to control these switches could allow researchers to turn telomerase activity up in aging cells or down in cancer cells.
He studies how structural changes to chromosomes impact gene expression and cell fate with a focus telomere, telomerase, and chromosomal stability, epigenetic proteins, and the role of the SOSS complex in DNA damage repair.
Lundblad's group has engineered yeast cells that lack telomerase, to study how cells respond to eroding telomeres when telomerase is not present to counter-balance.
Structural and biochemical characterization of these factors, both in isolation and in complex with one another will facilitate our understanding of how the proper function of these factors impacts telomerase function and cell proliferation.
Dr. Elizabeth Blackburn received the Nobel Prize in medicine in 2009 for discovering how chromosomes are protected by telomeres and the enzyme telomerase, which repairs and rebuilds them.
Do you know how significant this telomerase activity is?