I talked about
how your telomeres, the end caps of your chromosomes, determine how long you live.
Titia de Lange of The Rockefeller University is honored for her studies of
how telomeres shield chromosome ends and of the relationship between telomere dysfunction and cancer.
In her research, focused on exactly
how telomeres provide this protection, Dr. de Lange has uncovered several important pieces of the puzzle.
Dr. David Gilley's laboratory at the Indiana University School of Medicine in Indianapolis and Dr. Connie Eaves» laboratory at the BC Cancer Agency's Terry Fox Laboratory in Vancouver, Canada, collaborated to determine
how telomeres are regulated in different types of normal breast cells.
James Christiansen, professor of biology at Drake University in DesMoines, is studying
how telomeres, the simple, non-genetic DNAsequences that sheathe the ends of chromosomes, function in reptiles.Each time a healthy human cell divides, it loses a little bit of thetelomere, until the strands are too short to protect the chromosomes.At that point the DNA in a cell begins to break down, which triggerssenescence and death.
Karlseder is an expert in
how telomere biochemistry impacts cancer and aging.
Erosion of telomeres has long been associated with diseases of aging, but
how telomere length affects human disease has remained largely a mystery.
Not exact matches
In case you haven't heard enough about
how beneficial meditation can be, here's another way researchers have found that it helps: Family members who meditated for as little as 12 minutes a day for two months while caring for a relative with dementia improved their
telomere maintenance.
Voice: The 2009 Nobel Prize in Physiology or Medicine goes to Harvard's Jack Szostak, Johns Hopkins's Carol Greider and Elizabeth Blackburn at U.C. San Francisco for their work on
how chromosomes are protected by
telomeres and the enzyme telomerase.
Telomeres are essential parts of human cells that affect
how our cells age.
How much a certain change — say, running or cutting back on fat — is going to affect your
telomeres, if at all, is a level of specificity that the research can't yet provide.
Like a candle that burns an inch each hour and thus functions as a clock, can the length of our
telomeres tell us
how much longer we have to live?
Izpisua Belmonte added that more extensive studies will be needed to fully understand the role of heterochromatin disorganization in aging, including
how it interacts with other cellular processes implicated in aging, such as shortening of the end of chromosomes, known as
telomeres.
It is unclear
how the entire body is affected because Spector looked only at
telomeres, nucleotides on the ends of chromosomes that slowly erode as cells copy themselves during normal aging.
An essential part of human cells they affect
how our cells age — as people with longer
telomeres live longer lives.
Samani now plans to investigate
how the variant is making
telomeres shorter.
In this webinar, our experts will describe the advances in
telomere research as it applies to human health and
how deeper characterization of the telomerase maintenance process can uncover targets for therapies.
A new imaging technique has allowed researchers at North Carolina State University, the University of North Carolina at Chapel Hill, and the University of Pittsburgh to see
how DNA loops around a protein that aids in the formation of a special structure in
telomeres.
«This could explain
how shortened
telomeres increase a person's risk of heart disease,» agrees Samani.
So
how do shortened
telomeres increase your risk of heart disease?
Participants were divided into five groups, based on
how much longer their
telomeres were than expected.
To understand
how telomerase RNA participates in mechanistic aspects of
telomere synthesis, we studied a conserved secondary structure adjacent to the template.
How does telomerase manage to bypass the protective function of
telomeres?
Shadyab said future studies will examine
how exercise relates to
telomere length in younger populations and in men.
However, we still know very little about
how an animal's environment per se affects TL and
telomere attrition [11].
We reciprocally cross-fostered urban and rural nestling great tits (Parus major L.) to study
how growing up in an urban versus rural habitat affected
telomere length (TL)-- a suggested biomarker of longevity.
We are currently studying the mechanisms by which
telomeres are recruited to these structures and
how recombination reactions, which are normally suppressed at
telomeres, are allowed in the ALT context.
He studies
how structural changes to chromosomes impact gene expression and cell fate with a focus
telomere, telomerase, and chromosomal stability, epigenetic proteins, and the role of the SOSS complex in DNA damage repair.
LA JOLLA —
Telomeres, specialized ends of our chromosomes that dictate
how long cells can continue to duplicate themselves, have long been studied for their links to the aging process and cancer.
Lundblad's group has engineered yeast cells that lack telomerase, to study
how cells respond to eroding
telomeres when telomerase is not present to counter-balance.
The
Telomere Effect includes information on
how sleep, exercise, diet and even our social connections profoundly affect our
telomeres and
how chronic stress can eat away at them.
In The
Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer, Blackburn — together with co-author Elissa Epel, a leading health psychologist at the University of California San Francisco who studies stress, aging, and obesity — outlines
how the length and maintenance of one's
telomeres provide a biological basis for bettering health.
Telomeres work to keep chromosome ends from deteriorating or fusing with a neighboring chromosome, affecting
how quickly cells age and die.
Dr. Elizabeth Blackburn received the Nobel Prize in medicine in 2009 for discovering
how chromosomes are protected by
telomeres and the enzyme telomerase, which repairs and rebuilds them.
During the DNA replication process,
telomeres keep the DNA together (like
how the plastic caps on the end of shoelaces keep them from unraveling).
By clinically looking at your
telomere lengths you can gain insight into
how rapidly or slowly your body is aging.
As time passes,
telomeres become shorter; their length is an excellent predictor of health and longevity, and a lot of research on aging focuses on
how to protect them from shortening.
How exactly does exercise protect our
telomeres?
Telomeres play a pivotal role in
how we age and
how long we live.
Somebody will write a book / blog about the amazing benefits of drinking O.P.P. (e.g.
how it cleans plaque out of your arteries, decreases inflammation, and lengthens
telomeres — significantly more than drinking your own!).
«Future studies can provide mechanistic understanding by examining
how specific compounds in coffee are involved in
telomere maintenance.»
From understanding
how growing older impacts various bodily systems to the biological differences in the way aging effects men and women; the latest science on
telomeres and slowing the rate of cognitive decline to
how meditation heals us and why love, friendship, and laughter matter for health, The Longevity Book offers an all - encompassing, holistic look at
how the female body ages — and what we can all do to age better.
Telomeres are essential parts of human cells that influence
how quickly our cells age.
-- Mediterranean Diet — Heart disease: causes & reversal — Fiber — Gut bacteria — Flax — Diabetes — Junk science meant to confuse consumers — Dementia — High antioxidant foods, not antioxidant supplements — Body builders: vegan vs omnivore &
how much protein do we need — Hemed vs non-hemed iron —
Telomeres — Prostate health
Can the length of your
telomeres help predict
how long you'll -LSB-...]
Also, on the
telomere improvement —
how much time passed between the 2 measurements?
I'm just wondering, when Ornish says that a vegan diet along with exercise can boost
telomere strength —
how much exercise must one do?
I would love to believe that we can lengthen our
telomere with a low fat whole foods vegan diet but I don't see
how this proves it... Please help me understand!
This study documented, also for the first time, that these lifestyle changes may significantly increase an enzyme that lengthens
telomeres — the ends of your chromosomes that control
how long you live.
Eating fish appeared to age people's DNA six years, and processed meat 14 years, in terms of
how short the
telomeres were of fish - and lunch - meat - eaters.