Sentences with phrase «how transcription factors»

In particular, understanding how transcription factors (TFs) bind in a sequence specific manner to the DNA and how the alteration of transcriptional regulation contributes to cancer.

By understanding how the transcription factors work together during heart development, researchers may discover new ways to treat heart disease.

To understand defective disease process, investigators need to track where and how transcription factors bind to DNA to identify the differences between healthy and diseased cells.

The researchers led by Prof. Mihaela Zavolan and Prof. Anne Spang, both at the Biozentrum of the University of Basel, have discovered how the transcription factor Gcn4, a protein that regulates the expression of many genes, extends the life of baker's yeast Saccharomyces cerevisiae.

A famous example of how transcription factor expression can be used to alter a cell's identity is the creation of iPSCs, where adult cells were forced to express transcription factors normally expressed in ESCs, which made the adult cells express genes specific to ESCs, and consequently become nearly identical to ESCs.

Protein generation, one molecule at a time in E. coli cells, has been observed and studied including how a transcription factor binds to DNA and regulates gene expression.

Working in Brennan's lab, she took on the challenge of understanding how a transcription factor in soil bacteria regulates a transporter of multiple drugs.

Also relevant are studies of the upstream mechanisms that regulate levels and function of those gene products, for example: how a transcription factor regulates multiple targets or how factors can regulate translation or post-translational modification of multiple proteins.

Not exact matches

Two factors have led many observers to label this an early church homily on «how to hear God's word,» rather than a direct transcription of Jesus» own words.

The Cincinnati Children's research team has discovered a new clue about how the virus does this, a process that involves tiny proteins called transcription factors.

The Cincinnati Children's team suspects that the EBNA2 transcription factor from EBV is helping change how infected B cells operate, and how the body responds to those infected cells.

To see how the mutation affects alpha - synuclein production, the researchers identified two transcription factors that bind to the enhancer that carries this mutation.

Boldrini says that future research on the aging brain will continue to explore how neural cell proliferation, maturation, and survival are regulated by hormones, transcription factors, and other inter-cellular pathways.

In the journal Cell Reports, published today online, the scientists describe how the powerful master regulatory transcription factor Bcl6 regulates the genome, ensuring that aggressive lymphomas survive and thrive.

In the paper, the researchers illustrate how it could influence proteins that activate the transcription factors that transcribe major bone - related genes to drive bone formation — showing a link between metabolite usage and activation of transcription factors.

Others have tracked the first few hours of the embryonic development of sea urchins and other organisms with the goal of seeing how various transcription factors alter gene expression over time.

The oxidation status of STAT3, in turn, determined how efficiently the transcription factor regulates gene activity.

Modeling and experiments show how a key transcription factor uses biochemical feedback in two separate pathways to trigger either sustained or transient inflammation.

Together, the discovery of such rapid dynamic modes within chromatin fibers provides new insight how processes can gain access to the DNA (or are prevented to do so), such as transcription factors, or the machinery for transcription, replication or DNA repair.

More specifically, how a genetic transcription factor called hypoxia - inducible factor 1 (HIF - 1) helps our bodies adapt to low - oxygen environments, and how modifying that factor could help treat anemia and cancers.

The study, led by Dr. Maximilian Muenke of the National Human Genome Research Institute in Bethesda, Maryland, brings scientists closer to understanding how ADGRL3 contributes to risk by providing functional evidence that implicates a transcription factor in the pathology of the disorder.

«What was really cool about this research was we've known for a long time that a lot of different transcription factors were involved, but it was hard to understand how all the pieces fit together,» said Jenny Mortimer, director of plant systems biology at the Joint BioEnergy Division, a part of the Department of Energy.

In early work in Sweden, Jansson and his team investigated how distribution of sugars in plants could be controlled by a special protein called a transcription factor, which binds to certain genes and turns them on or off.

«Our research revealed how small RNA molecules can work with other cell signals called transcription factors to generate specific types of neurons, in this case motor neurons.

Although we know that Hox transcription factors specify the identity of individual fingers, toes, and ribs, little is known about how their individual sizes are programmed.

For instance, we do not yet fully understand how overall levels of «transcription factors» are regulated.

«We wanted to understand how stem cell transcription factors were interconnected and explain how these cells behave in different culture conditions and still maintain the stem cell state,» said Smith.

But how can we induce astrocyte to NSC conversion without the ectopic expression of neurogenic transcription factors?

The remaining models all contained a core network of 12 transcription factors — including Sox2 and Oct4 — that captured how self - renewal is regulated through just 16 interactions.

Finally, I will show how we have combined our results to generate a model of hematopoietic differentiation where specific transcription factors control lineage regulatory regions; our model predicts many already known lineage - controlling factors as well as finds new potential regulators of hematopoietic differentiation such as ATF3 in monocytes and Tcf7l2 and Runx2 in NK cells.

What are the direct targets of key transcription factors that regulate cardiogenesis and cardiomyocyte differentiation and how do they function in networks?

We want to understand how different RFX transcription factors are required for ciliogenesis control and how they are involved in ciliary specialization in mouse tissues.

During his doctoral and post-doctoral work under the mentorship of Jeffrey Goldberg, MD, PhD, and Larry Benowitz, PhD, Dr. Trakhtenberg discovered (1) how Set - β and PP2A proteins regulate axon growth; (2) the role of serotonin receptor 2C in neurite growth and processing of visual information; and (3) that inhibiting the transcription factor Klf9 acts synergistically with zinc chelation in stimulating axon regeneration.

In a new study published in the journal Science, a team of researchers has described how DNA - binding proteins (called transcription factors) react to and interpret these «epigenetic» changes.

Boldrini says that future research on the ageing brain will continue to explore how neural cell proliferation, maturation, and survival are regulated by hormones, transcription factors, and other inter-cellular pathways.

«This study identifies how the modification of the DNA structure affects the binding of transcription factors, and this increases our understanding of how genes are regulated in cells and further aids us in deciphering the grammar written into DNA,» study co-author Jussi Taipale from Karolinska Institutet in Sweden said in a statement.

Both genes turned out to be «transcription factors,» proteins that control how and when other genes are turned on or off.

Next, the scientists created cardiac cells missing the same transcription factors to investigate how their interactions affect gene expression.

Other projects focus on studying how mutations found in the genes for skeletogenic transcription factors cause skeletal and other defects in human patients and finding ways to overcome the negative effects of these mutations in patients.

SAN FRANCISCO, CA — Scientists at the Gladstone Institutes have discovered that three transcription factors — proteins that direct gene expression — interact with each other and the genome to influence how a heart forms in an embryo.

In the second webinar, you will learn how to apply basic concepts of flow cytometry to topics such as cell proliferation, dead cell exclusion, and intracellular staining techniques for transcription factors and phospho - proteins.

In recent work, Drs. Goldstein and Brown discovered the SREBP family of transcription factors and showed how these membrane - bound molecules control the synthesis of cholesterol and fatty acids through a newly described process of Regulated Intramembrane Proteolysis.

«Our goal is to figure out how mithramycin interacts with oncogenic transcription factors,» says Tsodikov.

Three Presentations, a double - sided worksheet on epigenetics and a fun class quiz which cover the following topics: Transcription Factors and the Oestrogen Receptor, DNA methylation and Histone Acetylation (epigenetics), RNA interference, as well as how these are implicated in cancers.