Sentences with phrase «how tumour cells»

But until now how the tumour cells affect and influence the surrounding tissue between dogs and humans has been unknown.

We are investigating how tumour cells can disseminate from the primary tumour and remain alive but clinically undetectable for many years, and how they start expanding into life threatening cancers in some patients.

Not exact matches

Researchers at the University of Gothenburg are focusing on how HAMLET can be taken up into tumour cells.

This early stage research will explore how the virus targets stem cells and provide the starting point to develop new treatments that seek out the tumour and spare the surrounding healthy brain tissue.

The Lund University research team has looked at how cancer cells communicate with surrounding cells and how this encourages the development of malignant tumours.

How do the genetically diverse cells in a tumour interact, for example, and what is the role of the cellular environment that they inhabit?

But at the time, they thought it might take years to pinpoint the precise position of the gene, sequence it, and understand how it causes mutations to accumulate in tumour cells (This Week, 15 May).

Breast cancer researchers have mapped early genetic alterations in normal - looking cells at various distances from primary tumours to show how changes along the lining of mammary ducts can lead to disease.

For the first time ever, we could make a really comprehensive comparison of individual normal and tumour cells from the exact same type of tissue, taken at the same time, from the same person, and see how the cancer had developed.»

To carry out the study, the team has analysed how different carbohydrates act on the surface of silver nanoparticles (Ag - NP) of around 50 nanometres, which have been introduced into cultures of liver cells and tumour cells from the nervous system of mice.

So if biologists can discover how to disable cancer cells» DNA repair proteins, it may be possible to destroy tumours using lower doses of radiation or drugs.

After testing if the cells remained viable, or alive, after printing, the researchers examined how the cells proliferated, how they expressed a specific set of proteins that help tumours spread, and how resistant the cells were to anti-cancer drugs.

This bank of living tumour cells allowed the team to study not only the genetics of the cells, but also how genetic mutations in the mitochondria — which drive energy production in the cell — caused changes in the cell's metabolism.

Putting together their analyses of the mitochondrial DNA in each tumour cell line and the metabolic pathways at work, the team were able to deduce how each cell line's genetics directly affected its ability to multiply.

The researchers, working with cell cultures, first observed how individual tumour cells kill specific cells in the vascular wall, called endothelial cells.

A key question in cancer research has been how cancer cells are able to survive once they break away from a tumour to spread around the body.

«Our research focuses particularly on the activity of this gene and how it relates to neuroblastoma,» says Professor Marie Arsenian - Henriksson at the Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet.

We believe that each dog breed may correspond to one type of B - or T - cell lymphoma and so studies within and between breeds gives us a unique possibility to understand how the genetic background affects what type of tumour develops, and how its progression is regulated», says Ingegerd Elvers.

Dr Claus Jorgensen, who led the research at The Institute of Cancer Research, London, and at Cancer Research UK's Manchester Institute at the University of Manchester, said: «The next step is to figure out how to keep this receptor switched on, so that the tumour cells can't leave the blood vessels — stopping breast cancer spreading and making the disease easier to treat successfully.»

«It suggests to us that targeting the pathways used in regulating cell fate decisions — how stem cells choose between cell proliferation and differentiation — could be a more effective way of halting tumours in their tracks and lead to potential new therapies.»

In this film Professor Sir Mike Stratton (director of the Wellcome Trust Sanger Institute) describes how mutations in DNA can cause a cell to grow out of control and develop into a cancerous tumour.

We target tumours by exploring how the proteins found on the cancer cell surface can be utilised to inhibit growth or kill tumours.

Understanding the processes that restrain mutant cells from developing into tumours, and how they are breached when cancers do form will guide the development of strategies to reduce the chance of cancer development in individuals who have acquired a high level of mutations.

«It tells you about the ecosystem of the tumour», Simona says, «using fluorescent markers, we can label many specific cell types and structures within the brain in the vicinity of the tumour, and look not just at the tumour cells but how they interact with their surroundings.

Professor Dive's exhibit was designed to introduce visitors to the concept of circulating tumour cells (CTCs) and how liquid biopsies could hold the key for better diagnosis and treatment of lung cancer.

Here Steve tells us how his interest in stem cells led him into cancer research and how he believes this angle of brain tumour research has unique potential for tackling cancers which are currently difficult to treat.

Steve tells us how his interest in stem cells led him into cancer research, and the potential for breakthroughs in brain tumour research and treatment.

Recent evidence indicates that non-cancerous support cells within tumours, referred to as the stroma are emerging as key sources of tumour - promoting inflammation, but little is known how or when in tumour evolution these functions are acquired.

A better understanding of how the immune system works to fight cancer and a detailed characterisation of the different immune cells that infiltrate a particular patient's tumour, would enable more efficient treatments.

Cancer cells multiply quickly and in a way that is out of control; this is how tumours are formed.

Kelley, lead investigator on the study published today in Nature Chemistry, explained how her team has advanced a completely new approach using magnetic nanoparticles with DNA capture probes on their surface that can target circulating tumour cells (CTCs) in blood samples to see if the cells contains biomarkers associated with drug resistance.

Areas of focus include: understanding how tumour - reactive T cells and B cells promote patient survival in cancer; defining the effects of standard treatments on tumor immunity; and using genomic approaches to identify novel tumour mutations that can serve as target antigens for immunotherapy.

The first step is to understand how a small fraction of the tumour cells often escape therapy while becoming more malignant.

The same thing happens (the inhibition of stated growth factors) with hyperbaric oxygen therapy so it makes sense how all this fits together in powerful synergy to increase metabolic stress on tumour cells.

· Cancer Growth and Spread — Healing Angiogenesis and Metastasis, discussing blood vessel development and growth factors, dysregulation including hypoxia and other blood supply stress responses in cancer and other diseases and how cancer cells travel and invade — metastasis via the complex tumour microenvironment — TME — comprised of immune cells, cytokines, growth factors, reactive oxygen species (ROS) and cancer - associated fibroblast (CAF);

Lectures provided on: Canine and Feline Lymphoma, What's new in Oncology, How to read a histopathology report; Canine mast cell tumours and TKIs; Canine Hemangiosarcoma.