Sentences with phrase «how ubiquitin»

This appears to be the first example of how the ubiquitin tagging mechanism found by Rose, Ciechanover, and Hershko is responsible for rendering a genetic switch ambiguous in a human embryo (or any other animal).

The researchers performed studies to determine how ubiquitin modification changes SIRT1 function.

Not exact matches

Aaron Ciechanover and Avram Hershko of the Rappaport Institute at the Technion - Israel Institute of Technology in Haifa and Irwin Rose of the University of California, Irvine, share this year's prize for work that established how a protein called ubiquitin tags other proteins for recycling.

The team sought to identify how BRCA1 manages to perform the ubiquitin attachment role, and found that it relies on a part of a partner protein, called BARD1.

Writing in the journal PLoS Pathogens, the team led by Professor Sachdev Sidhu, of the Donnelly Centre for Cellular and Biomolecular Research and Department of Molecular Genetics, describe how they turned ubiquitin, a staple protein in every cell, into a drug capable of thwarting MERS in cultured human cells.

To understand how Parkin and other RBR ubiquitin ligase enzymes achieve this, EMBO Young Investigator David Komander and his coworker Tobias Wauer crystallized a form of human Parkin and used X-ray diffraction patterns to determine how the Parkin protein chain folds into a three - dimensional structure.

They have contributed ground - breaking chemical knowledge of how the cell can regulate the presence of a certain protein by marking unwanted proteins with a label consisting of the polypeptide ubiquitin.

Recently, he has been focusing on the regulation of a family of yeast purine - cytosine permeases, including the transcriptional controls over their expression, and how, after these proteins bind to their cargo, they are targeted by the ubiquitin system for endocytosis and delivery to the vacuole.

Several years later, Varshavsky showed how the individual ubiquitin molecules hook up in these chains.

The Steffan laboratory is being funded by the Hereditary Disease Foundation to investigate how the Huntingtin protein interacts with the ubiquitin - tagged trash in order to scaffold it to the lysosome for degradation, and to figure out what kinds of trash may be cleaned up by Huntingtin.